Search Results - "Ekenstedt, J"

TLR4 and MD2 variation among horses with differential TNFα baseline concentrations and response to intravenous lipopolysaccharide infusion by Mukhopadhyay, Abhijit, Cook, Shawna R., SanMiguel, Phillip, Ekenstedt, Kari J., Taylor, Sandra D.

“…Gram-negative bacterial septicemia is mediated through binding of lipopolysaccharide (LPS) to mammalian toll-like receptor protein 4 (TLR4). TLR4 and its…”
Get full text

True Colors: Commercially-acquired morphological genotypes reveal hidden allele variation among dog breeds, informing both trait ancestry and breed potential by Dreger, Dayna L, Hooser, Blair N, Hughes, Angela M, Ganesan, Balasubramanian, Donner, Jonas, Anderson, Heidi, Holtvoigt, Lauren, Ekenstedt, Kari J

“…Direct-to-consumer canine genetic testing is becoming increasingly popular among dog owners. The data collected therein provides intriguing insight into the…”
Get full text

SNP‐based heritability and genetic architecture of cranial cruciate ligament rupture in Labrador Retrievers by Cook, S. R., Conzemius, M. G., McCue, M. E., Ekenstedt, K. J.

“…Summary Cranial cruciate ligament rupture (CCLR) is one of the leading causes of pelvic limb lameness in dogs. About 6% of Labrador Retrievers suffer from this…”
Get full text

Frequency of five disease-causing genetic mutations in a large mixed-breed dog population (2011-2012) by Zierath, Sharon, Hughes, Angela M, Fretwell, Neale, Dibley, Mark, Ekenstedt, Kari J

“…A large and growing number of inherited genetic disease mutations are now known in the dog. Frequencies of these mutations are typically examined within the…”
Get full text

A GJA9 frameshift variant is associated with polyneuropathy in Leonberger dogs by Becker, Doreen, Minor, Katie M, Letko, Anna, Ekenstedt, Kari J, Jagannathan, Vidhya, Leeb, Tosso, Shelton, G Diane, Mickelson, James R, Drögemüller, Cord

“…Many inherited polyneuropathies (PN) observed in dogs have clinical similarities to the genetically heterogeneous group of Charcot-Marie-Tooth (CMT) peripheral…”
Get full text

A large animal model for CNGB1 autosomal recessive retinitis pigmentosa by Winkler, Paige A, Ekenstedt, Kari J, Occelli, Laurence M, Frattaroli, Anton V, Bartoe, Joshua T, Venta, Patrick J, Petersen-Jones, Simon M

“…Retinal dystrophies in dogs are invaluable models of human disease. Progressive retinal atrophy (PRA) is the canine equivalent of retinitis pigmentosa (RP)…”
Get full text

An ARHGEF10 deletion is highly associated with a juvenile-onset inherited polyneuropathy in Leonberger and Saint Bernard dogs by Ekenstedt, Kari J, Becker, Doreen, Minor, Katie M, Shelton, G Diane, Patterson, Edward E, Bley, Tim, Oevermann, Anna, Bilzer, Thomas, Leeb, Tosso, Drögemüller, Cord, Mickelson, James R

“…An inherited polyneuropathy (PN) observed in Leonberger dogs has clinical similarities to a genetically heterogeneous group of peripheral neuropathies termed…”
Get full text

Prevalence of the AMHR2 mutation in Miniature Schnauzers and genetic investigation of a Belgian Malinois with persistent Müllerian duct syndrome by Smit, MM, Ekenstedt, KJ, Minor, KM, Lim, CK, Leegwater, PAJ, Furrow, E

“…Contents Persistent Müllerian duct syndrome (PMDS) is a sex‐limited disorder in which males develop portions of the female reproductive tract. Important…”
Get full text

Network topology of stable isotope interactions in a sub-arctic raptor guild by Dalerum, F., Hellström, P., Miranda, M., Nyström, J., Ekenstedt, J., Angerbjörn, A.

“…Predation is an ecologically important process, and intra-guild interactions may substantially influence the ecological effects of predator species. Despite a…”
Get full text

Heritability and genome-wide association study of vaccine-induced immune response in Beagles: A pilot study by Blake, Jeanna M., Thompson, James, HogenEsch, Harm, Ekenstedt, Kari J.

“…•The immune response to vaccination is moderately heritable in dogs.•Many SNPs of low to high effect contribute to vaccine-induced immune response.•Genes…”
Get full text

Presence and impact of the exercise-induced collapse associated DNM1 mutation in Labrador retrievers and other breeds by Minor, Katie M., Patterson, Edward E., Keating, Marguerite K., Gross, Stephanie D., Ekenstedt, Kari J., Taylor, Susan M., Mickelson, James R.

“…The impact of the mutation causing dynamin 1 ( DNM1)-associated exercise-induced collapse (d-EIC) was determined in a retrospective genetic survey. The…”
Get full text

Canine Brachycephaly: Anatomy, Pathology, Genetics and Welfare by Ekenstedt, K.J., Crosse, K.R., Risselada, M.

“…Brachycephalic dog breeds have experienced a marked rise in popularity in recent years. While numerous people clearly desire this phenotype in their pets, many…”
Get full text

Canine RNF170 Single Base Deletion in a Naturally Occurring Model for Human Neuroaxonal Dystrophy by Cook, Shawna R., Schwarz, Cleo, Guevar, Julien, Assenmacher, Charles‐Antoine, Sheehy, Maeve, Fanzone, Nathan, Church, Molly E., Murgiano, Leonardo, Casal, Margret L., Jagannathan, Vidhya, Gutierrez‐Quintana, Rodrigo, Lowrie, Mark, Steffen, Frank, Leeb, Tosso, Ekenstedt, Kari J.

“…Background Neuroaxonal dystrophy (NAD) is a group of inherited neurodegenerative disorders characterized primarily by the presence of spheroids (swollen axons)…”
Get full text

Special topic: The association between pulse ingredients and canine dilated cardiomyopathy: addressing the knowledge gaps before establishing causation by Mansilla, Wilfredo D, Marinangeli, Christopher P F, Ekenstedt, Kari J, Larsen, Jennifer A, Aldrich, Greg, Columbus, Daniel A, Weber, Lynn, Abood, Sarah K, Shoveller, Anna K

“…In July 2018, the Food and Drug Administration warned about a possible relationship between dilated cardiomyopathy (DCM) in dogs and the consumption of dog…”
Get full text

A SACS deletion variant in Great Pyrenees dogs causes autosomal recessive neuronal degeneration by Ekenstedt, Kari J., Minor, Katie M., Shelton, G. Diane, Hammond, James J., Miller, Andrew D., Taylor, Susan M., Huang, Yanyun, Mickelson, James R.

“…ARSACS (autosomal recessive spastic ataxia of Charlevoix-Saguenay) is a human neurological disorder characterized by progressive cerebellar ataxia and…”
Get full text

Canine models of Charcot-Marie-Tooth: MTMR2, MPZ, and SH3TC2 variants in golden retrievers with congenital hypomyelinating polyneuropathy by Cook, Shawna, Hooser, Blair N, Williams, D. Colette, Kortz, Gregg, Aleman, Monica, Minor, Katie, Koziol, Jennifer, Friedenberg, Steven G., Cullen, Jonah N, Shelton, G. Diane, Ekenstedt, Kari J

“…•Neurological testing confirmed a hypomyelinating polyneuropathy (HPN) in four dogs.•Variants in MTMR2, MPZ, and SH3TC2 were identified by whole-genome…”
Get full text

Global Frequency Analyses of Canine Progressive Rod-Cone Degeneration-Progressive Retinal Atrophy and Collie Eye Anomaly Using Commercial Genetic Testing Data by Clark, Jessica A, Anderson, Heidi, Donner, Jonas, Pearce-Kelling, Susan, Ekenstedt, Kari J

“…Hundreds of genetic variants associated with canine traits and disorders have been identified, with commercial tests offered. However, the geographic…”
Get full text

Investigation of a common canine factor VII deficiency variant in dogs with unexplained bleeding on autopsy by Clark, Jessica A., Hooser, Stephen B., Dreger, Dayna L., Burcham, Grant N., Ekenstedt, Kari J.

“…The factor VII (FVII) protein is an integral component of the extrinsic coagulation pathway. Deleterious variants in the gene encoding this protein can result…”
Get full text

Juvenile‐onset motor polyneuropathy in Siberian cats by Crawford, Kelly C., Dreger, Dayna L., Shelton, G. Diane, Ekenstedt, Kari J., Lewis, Melissa J.

“…Background Polyneuropathies are infrequently described in cats. There is a genetic predisposition in several breeds. Objective To clinically characterize a…”
Get full text

Mapping the locus for ocular melanosis in Cairn Terriers by Winkler, Paige A, Dawson-Baglien, Ethan M, Coffey, Madeline C, Venta, Patrick J, Ekenstedt, Kari J, Petersen-Jones, Simon M

“…To map the disease locus for familial ocular melanosis (OM) in the Cairn Terrier. Cairn Terriers with OM and normal control dogs. A genome-wide association…”
Get full text