Search Results - "Ekdahl, Anja"

Combined in Vitro–in Vivo Approach To Assess the Hepatobiliary Disposition of a Novel Oral Thrombin Inhibitor by Matsson, Elin M, Eriksson, Ulf G, Palm, Johan E, Artursson, Per, Karlgren, Maria, Lazorova, Lucia, Brännström, Marie, Ekdahl, Anja, Dunér, Kristina, Knutson, Lars, Johansson, Susanne, Schützer, Kajs-Marie, Lennernäs, Hans

“…Two clinical trials and a large set of in vitro transporter experiments were performed to investigate if the hepatobiliary disposition of the direct thrombin…”
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Systemic exposure to the metabolites of lesogaberan in humans and animals: a case study of metabolites in safety testing by Holmberg, Ann Aurell, Ekdahl, Anja, Weidolf, Lars

“…During preclinical and early phase clinical studies of drug candidates, exposure to metabolites should be monitored to determine whether safety conclusions…”
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Biotransformation of the Novel Myeloperoxidase Inhibitor AZD4831 in Preclinical Species and Humans by Jurva, Ulrik, Weidolf, Lars, Sandinge, Ann-Sofie, Leandersson, Carina, Ekdahl, Anja, Li, Xue-Qing, Antonsson, Thomas, Sundell, Johan, Westerlund, Kristina, Amilon, Carl, Inghardt, Tord, Gopaul, V Sashi

“…We report herein an in-depth analysis of the metabolism of the novel myeloperoxidase inhibitor AZD4831 ((…”
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Tracing and separating plasma components causing matrix effects in hydrophilic interaction chromatography–electrospray ionization mass spectrometry by Ekdahl, Anja, Johansson, Maria C., Ahnoff, Martin

“…► Polar endogenous compounds in plasma identified to interfere in HILIC–ESI-MS. ► Both enhancement and suppression of the analyte signal was observed. ►…”
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A simple and sensitive method for the determination of volatile halogenated organic compounds in sea water in the amoll−1 to pmoll−1 range by Ekdahl, Anja, Abrahamsson, Katarina

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The metabolic fate of fenclozic acid in chimeric mice with a humanized liver by Ekdahl, Anja, Weidolf, Lars, Baginski, Matthew, Morikawa, Yoshio, Thompson, Richard A., Wilson, Ian D.

“…The metabolic fate of the human hepatotoxin fenclozic acid ([2-(4-chlorophenyl)-1,3-thiazol-4-yl]acetic acid) (Myalex) was studied in normal and…”
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Identification of the metabolites of lesogaberan using linear trap quadrupole orbitrap mass spectrometry and hydrophilic interaction liquid chromatography by Ekdahl, Anja, Aurell-Holmberg, Ann, Castagnoli, Neal

“…1. In this study, hydrophilic interaction liquid chromatography (HILIC), radiochemical activity monitoring and linear trap quadrupole orbitrap mass…”
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Matrix effect explained by unexpected formation of peptide in acidified plasma by Ahnoff, Martin, Nyström, Ann-Christin, Schweikart, Fritz, Ekdahl, Anja

“…Peak distortion and strong signal enhancement was observed when applying a bioanalytical method based on mixed-mode SPE, hydrophilic interaction chromatography…”
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A study of the diurnal variation of biogenic volatile halocarbons by Ekdahl, Anja, Pedersén, Marianne, Abrahamsson, Katarina

“…The diurnal variation of a number of naturally produced volatile halogenated organic compounds (VHOC) in a pool at Gran Canaria, Spain, is shown. The diurnal…”
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A simple and sensitive method for the determination of volatile halogenated organic compounds in sea water in the amol l −1 to pmol l −1 range by Ekdahl, Anja, Abrahamsson, Katarina

“…Volatile halogenated organic compounds in sea water were determined in automated purge and trap systems connected to either a gas-chromatograph with an…”
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Stress-induced production of volatile halogenated organic compounds in Eucheuma denticulatum (Rhodophyta) caused by elevated pH and high light intensities by Mtolera, Matern S.P., Collén, Jonas, Pedersén, Marianne, Ekdahl, Anja, Abrahamsson, Katarina, Semesi, Adelaida K.

“…Eucheuma denticulatum has been shown to release bromoform, diiodomethane, dibromochloromethane, perchloroethylene, chloroiodomethane, chloroform, sec-butyl…”
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