Search Results - "Ekblom, Peter"

Laminin isoforms in development and disease by SCHEELE, Susanne, NYSTRÖM, Alexander, DURBEEJ, Madeleine, TALTS, Jan F, EKBLOM, Marja, EKBLOM, Peter

“…The members of the laminin family of heterotrimers are major constituents of all basement membranes, sheet-like extracellular structures, present in almost all…”
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Expression and biological role of laminin-1 by Ekblom, Peter, Lonai, Peter, Talts, Jan F.

“…Of the approximately 15 laminin trimers described in mammals, laminin-1 expression seems to be largely limited to epithelial basement membranes. It appears…”
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Limited expression of nuclear pore membrane glycoprotein 210 in cell lines and tissues suggests cell-type specific nuclear pores in metazoans by Olsson, Magnus, Schéele, Susanne, Ekblom, Peter

“…The nuclear pore complex (NPC) is the only known gateway for nucleocytoplasmic traffic. The nuclear pore membrane glycoprotein 210 (POM210/gp210) is considered…”
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Distinct GATA6- and laminin-dependent mechanisms regulate endodermal and ectodermal embryonic stem cell fates by Li, Li, Arman, Esther, Ekblom, Peter, Edgar, David, Murray, Patricia, Lonai, Peter

“…This study investigates the establishment of alternative cell fates during embryoid body differentiation when ES cells diverge into two epithelia simulating…”
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Laminin isoform–specific promotion of adhesion and migration of human bone marrow progenitor cells by Gu, Yu-Chen, Kortesmaa, Jarkko, Tryggvason, Karl, Persson, Jenny, Ekblom, Peter, Jacobsen, Sten-Eirik, Ekblom, Marja

“…Laminins are αβγ heterotrimeric extracellular proteins that regulate cellular functions by adhesion to integrin and nonintegrin receptors. Laminins containing…”
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Laminin α1-Chain Shows a Restricted Distribution in Epithelial Basement Membranes of Fetal and Adult Human Tissues by Virtanen, Ismo, Gullberg, Donald, Rissanen, Jan, Kivilaakso, Eero, Kiviluoto, Tuula, Laitinen, Lauri A., Lehto, Veli-Pekka, Ekblom, Peter

“…Two novel monoclonal antibodies were raised and used to study the expression of laminin (Ln) α1-chain in developing and adult human tissues. In both fetal and…”
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Fibroblast Growth Factor Signaling and Basement Membrane Assembly Are Connected during Epithelial Morphogenesis of the Embryoid Body by Li, Xiaofeng, Chen, Yali, Schéele, Susanne, Arman, Esther, Haffner-Krausz, Rebecca, Ekblom, Peter, Lonai, Peter

“…Fibroblast growth factors and receptors are intimately connected to the extracellular matrix by their affinity to heparan sulfate proteoglycans. They mediate…”
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Presence of Laminin α5 Chain and Lack of Laminin α1 Chain during Human Muscle Development and in Muscular Dystrophies by Tiger, Carl-Fredrik, Champliaud, Marie-France, Pedrosa-Domellof, Fatima, Thornell, Lars-Eric, Ekblom, Peter, Gullberg, Donald

“…There is currently a great interest in identifying laminin isoforms expressed in developing and regenerating skeletal muscle. Laminin α1 has been reported to…”
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Laminin α1 Globular Domains 4-5 Induce Fetal Development but Are Not Vital for Embryonic Basement Membrane Assembly by Schéele, Susanne, Falk, Mats, Franzén, Ahnders, Ellin, Fredrik, Ferletta, Maria, Lonai, Peter, Andersson, Björn, Timpl, Rupert, Forsberg, Erik, Ekblom, Peter, Anderson, Kathryn V.

“…During early mouse embryogenesis, each laminin (Lm) chain of the first described Lm, a heterotrimer of α1, β1, and γ1 chains (Lm-1), is essential for basement…”
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Laminin-1 Promotes Angiogenesis in Synergy with Fibroblast Growth Factor by Distinct Regulation of the Gene and Protein Expression Profile in Endothelial Cells by Dixelius, Johan, Jakobsson, Lars, Genersch, Elke, Bohman, Svante, Ekblom, Peter, Claesson-Welsh, Lena

“…Laminins are widely distributed extracellular matrix proteins. Certain laminin isoforms are predominant in vascular basement membranes and may be critical in…”
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Laminin Isoforms and Epithelial Development by EKBLOM, MARJA, FALK, MATS, SALMIVIRTA, KATRIINA, DURBEEJ, MADELEINE, EKBLOM, PETER

“…Several different approaches suggest that basement‐membrane assembly is important for epithelial development. Basement membranes contain isoforms of collagen…”
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Opposing Roles of Integrin α6Aβ1 and Dystroglycan in Laminin-mediated Extracellular Signal-regulated Kinase Activation by Ferletta, Maria, Kikkawa, Yamato, Yu, Hao, Talts, Jan F., Durbeej, Madeleine, Sonnenberg, Arnoud, Timpl, Rupert, Campbell, Kevin P., Ekblom, Peter, Genersch, Elke

“…Laminin–integrin interactions can in some settings activate the extracellular signal-regulated kinases (ERKs) but the control mechanisms are poorly understood…”
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Distribution of Dystroglycan in Normal Adult Mouse Tissues by Durbeej, Madeleine, Henry, Michael D, Ferletta, Maria, Campbell, Kevin P, Ekblom, Peter

“…Dystroglycan is a cell surface protein which, in muscle, links the extracellular matrix protein laminin-2 to the intracellular cytoskeleton. Dystroglycan also…”
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Akt/PKB Regulates Laminin and Collagen IV Isotypes of the Basement Membrane by Li, Xiaofeng, Talts, Ulrika, Talts, Jan F., Arman, Esther, Ekblom, Peter, Lonai, Peter

“…Basement membranes are important for epithelial differentiation, cell survival, and normal and metastatic cell migration. Much is known about their breakdown…”
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Role of laminin A chain in the development of epithelial cell polarity by Klein, G, Langegger, M, Timpl, R, Ekblom, P

“…Kidney organ culture was used to study the conversion of embryonic mesenchymal cells into a polarized, differentiated kidney epithelium. We examined the…”
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Role of mesenchymal nidogen for epithelial morphogenesis in vitro by EKBLOM, P, EKBLOM, M, FECKER, L, KLEIN, G, HONG-YAN ZHANG, KADOYA, Y, MON-LI CHU, MAYER, U, TIMPL, R

“…Recent biochemical studies suggested that the extracellular matrix protein nidogen is a binding molecule linking together basement membrane components. We…”
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Importance of nidogen binding to laminin γ1 for branching epithelial morphogenesis of the submandibular gland by Kadoya, Yuichi, Salmivirta, Katriina, Talts, Jan Fredrik, Kadoya, Kuniko, Mayer, Ulrike, Timpl, Rupert, Ekblom, Peter

“…ABSTRACT Epithelial-mesenchymal interactions are major driving forces for the development of most solid organs. The importance of these interactions was first…”
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Development of tubular and glomerular cells of the kidney by Sorokin, Lydia, Ekblom, Peter

“…Many of the functions of the kidney are carried out by two cell types, the epithelial and the endothelial cells. Epithelial cells constitute the distal and…”
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Vasculogenesis and angiogenesis in embryonic-stem-cell-derived embryoid bodies by Risau, W, Sariola, H, Zerwes, H G, Sasse, J, Ekblom, P, Kemler, R, Doetschman, T

“…Embryonic stem cells (ESC) have been established previously from the inner cell mass cells of mouse blastocysts. In suspension culture, they spontaneously…”
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Expression of laminin α1, α5 and β2 chains during embryogenesis of the kidney and vasculature by Durbeej, Madeleine, Fecker, Lothar, Hjalt, Tord, Zhang, Hong-Yan, Salmivirta, Kátriina, Klein, Gerd, Timpl, Rupert, Sorokin, Lydia, Ebendal, Ted, Ekblom, Peter, Ekblom, Marja

“…Laminins, found predominantly in basement membranes, are large glycoproteins consisting of different subsets of α, β and γ chain subunits. To resolve…”
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