Search Results - "Eisner, D.A"

What role does modulation of the ryanodine receptor play in cardiac inotropy and arrhythmogenesis? by Eisner, D.A, Kashimura, T, O'Neill, S.C, Venetucci, L.A, Trafford, A.W

“…Abstract In this article we review the role of the Ryanodine Receptor (RyR) in cardiac inotropy and arrhythmogenesis. Most of the calcium that activates…”
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The effect of 2,5-di-(tert-butyl)-1,4-benzohydroquinone (TBQ) on intracellular Ca2+ handling in rat ventricular myocytes by Miller, L, Greensmith, D.J, Sankaranarayanan, R, O’Neill, S.C, Eisner, D.A

“…Graphical abstract…”
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Reducing Ryanodine Receptor Open Probability as a Means to Abolish Spontaneous Ca2+ Release and Increase Ca2+ Transient Amplitude in Adult Ventricular Myocytes by Venetucci, L A, Trafford, A W, Díaz, M E, O’Neill, S C, Eisner, D A

“…The aim of this work was to investigate whether it is possible to remove arrhythmogenic Ca release from the sarcoplasmic reticulum that occurs in calcium…”
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Depressed Ryanodine Receptor Activity Increases Variability and Duration of the Systolic Ca2+ Transient in Rat Ventricular Myocytes by Díaz, M E, Eisner, D A, O’Neill, S C

“…ABSTRACT—Sarcoplasmic reticulum (SR) Ca release, through the ryanodine receptor (RyR), is essential for the systolic Ca transient and thus the cardiac…”
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Analysis of cellular calcium fluxes in cardiac muscle to understand calcium homeostasis in the heart by Dibb, K.M, Graham, H.K, Venetucci, L.A, Eisner, D.A, Trafford, A.W

“…Abstract Central to controlling intracellular calcium concentration ([Ca2+ ] i ) are a number of Ca2+ transporters and channels with the L-type Ca2+ channel,…”
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The control of sarcoplasmic reticulum Ca content in cardiac muscle by Díaz, M.E., Graham, H.K., O’Neill, S.C., Trafford, A.W., Eisner, D.A.

“…Most of the calcium that activates contraction in the heart comes from the sarcoplasmic reticulum (SR) and it is therefore essential to control the SR Ca…”
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Increased ICaL Underlies Ventricular Action-Potential Prolongation After Spontaneous Ca2+ Release From The Sarcoplasmic Reticulum by Johnson, D.M, Heijman, J, Bode, E.F, Greensmith, D.J, Abi-Gerges, N, Eisner, D.A, Trafford, A.W, Volders, P.G.A

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The control of Ca release from the cardiac sarcoplasmic reticulum : regulation versus autoregulation by EISNER, D. A, TRAFFORD, A. W, DIAZ, M. E, OVEREND, C. L, O'NEILL, S. C

“…This review discusses the mechanism and regulation of Ca release from the cardiac sarcoplasmic reticulum. Ca is released through the Ca release channel or…”
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Life, Sudden Death, and Intracellular Calcium by Eisner, D A, Venetucci, L A, Trafford, A W

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Measurement of sarcoplasmic reticulum Ca2+ content and sarcolemmal Ca2+ fluxes in isolated rat ventricular myocytes during spontaneous Ca2+ release by Díaz, M E, Trafford, A W, O'Neill, S C, Eisner, D A

“…1. Intracellular calcium concentration ([Ca2+]i) and Na(+)-Ca2+ exchange currents were measured in calcium-overloaded voltage-clamped rat ventricular myocytes…”
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A new technique for simultaneous and in situ measurements of Ca2+ signals in arteriolar smooth muscle and endothelial cells by Burdyga, T, Shmygol, A, Eisner, D A, Wray, Susan

“…We report here the first local and global Ca(2+) measurements made from in situ terminal arterioles. The advantages of the method are that there is minimal…”
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The effects of low concentrations of caffeine on spontaneous Ca release in isolated rat ventricular myocytes by Trafford, A.W., Sibbring, G.C., Díaz, M.E., Eisner, D.A.

“…We have investigated the effects on spontaneous SR Ca release of modulating the sarcoplasmic reticulum ryanodine receptor (RyR) with low (<0.5mM)…”
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Reproducibility of science: Fraud, impact factors and carelessness by Eisner, D.A.

“…There is great concern that results published in a large fraction of biomedical papers may not be reproducible. This article reviews the evidence for this and…”
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Heart Failure and the Ryanodine Receptor: Does Occam’s Razor Rule? by Eisner, D A, Trafford, A W

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The Effects of Exogenous Calcium Buffers on the Systolic Calcium Transient in Rat Ventricular Myocytes by Díaz, M.E., Trafford, A.W., Eisner, D.A.

“…The aim of this work was to characterize the effects that two commonly used “caged” calcium buffers (NP-EGTA and nitr-5) have on the amplitude and time course…”
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Illuminating Sarcoplasmic Reticulum Calcium by Venetucci, L, Trafford, A W, Eisner, D A

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The role of intracellular Ca buffers in determining the shape of the systolic Ca transient in cardiac ventricular myocytes by Díaz, M E, Trafford, A W, Eisner, D A

“…We have studied the kinetics of decay of cardiac Ca transients elicited by either caffeine or electrical stimulation. The decay of the caffeine-evoked increase…”
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Caffeine inhibits the agonist-evoked cytosolic Ca2+ signal in mouse pancreatic acinar cells by blocking inositol trisphosphate production by TOESCU, E. C, O'NEILL, S. C, PETERSEN, O. H, EISNER, D. A

“…The inhibitory effects of caffeine on receptor-activated cytosolic Ca2+ signal generation in isolated mouse pancreatic acinar cells were investigated. Using…”
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Susceptibility to atrial alternans; a role for transverse (t)-tubule loss in heart failure (HF)? by Madders, G.W.P., Woods, L., Hutchings, D.C., Waddell, C.A., Denham, N., Trafford, A.W., Eisner, D.A., Dibb, K.M.

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The effect of 2,5-di-(tert-butyl)-1,4-benzohydroquinone (TBQ) on intracellular Ca 2+ handling in rat ventricular myocytes by Miller, L., Greensmith, D.J., Sankaranarayanan, R., O’Neill, S.C., Eisner, D.A.

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