Search Results - "Eisenstein, Barry I"
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A comprehensive regulatory framework to address the unmet need for new antibacterial treatments
Published in The Lancet infectious diseases (01-03-2013)“…Summary To bring new antibacterial drugs to the market is challenging because discovery of new agents is difficult, two large trials per indication are needed…”
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Daptomycin: From the Mountain to the Clinic, with Essential Help from Francis Tally, MD
Published in Clinical infectious diseases (01-01-2010)“…Daptomycin has been approved and successfully launched for the treatment of complicated skin and skin-structure infections caused by gram-positive pathogens…”
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Lipopeptides, focusing on daptomycin, for the treatment of Gram-positive infections
Published in Expert opinion on investigational drugs (01-09-2004)“…The increasing incidence of serious infections caused by antibiotic-resistant Gram-positive bacteria has led to the development of new spectrum-specific…”
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Combating Antimicrobial Resistance: Policy Recommendations to Save Lives
Published in Clinical infectious diseases (01-05-2011)Get full text
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Decreasing the Probability of Creatine Phosphokinase Elevations: Clinical Considerations for Daptomycin Dosing in Obese Patients
Published in Clinical infectious diseases (15-10-2010)Get full text
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The evolution of the regulatory framework for antibacterial agents
Published in Annals of the New York Academy of Sciences (01-09-2014)“…The rising tide of antibacterial resistance and the lack of a diverse, vibrant pipeline of novel antibacterial agents is a global crisis that impairs our…”
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Progress in the Fight Against Multidrug-Resistant Bacteria 2005–2016: Modern Noninferiority Trial Designs Enable Antibiotic Development in Advance of Epidemic Bacterial Resistance
Published in Clinical infectious diseases (01-07-2017)“…From a public health perspective, new antibacterial agents should be evaluated and approved for use before widespread resistance to existing agents emerges…”
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Towards a global definition of responsible antibiotic use: results of an international multidisciplinary consensus procedure
Published in Journal of antimicrobial chemotherapy (01-06-2018)“…Abstract Background Conducted as part of the Driving Reinvestment in Research and Development and Responsible Antibiotic Use (DRIVE-AB) project, this study…”
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Development potential of rifalazil
Published in Expert opinion on investigational drugs (01-02-2003)“…Rifalazil represents a new generation of ansamycins that contain a unique four-ring structure. Originally rifalazil was developed as a therapeutic agent to…”
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The Safety and Efficacy of Daptomycin for the Treatment of Complicated Skin and Skin-Structure Infections
Published in Clinical infectious diseases (15-06-2004)“…Daptomycin is the first available agent from a new class of antibiotics, the cyclic lipopeptides, that has activity against a broad range of gram-positive…”
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Daptomycin versus vancomycin plus gentamicin for treatment of bacteraemia and endocarditis due to Staphylococcus aureus: subset analysis of patients infected with methicillin-resistant isolates
Published in Journal of antimicrobial chemotherapy (01-12-2008)“…Objectives In a prospective, randomized trial, daptomycin was non-inferior to standard therapy for Staphylococcus aureus bacteraemia and right-sided…”
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Addressing the need for new antibacterials – Authors' reply
Published in The Lancet infectious diseases (01-10-2013)Get full text
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The Polymerase Chain Reaction: A New Method of Using Molecular Genetics for Medical Diagnosis
Published in The New England journal of medicine (18-01-1990)“…THE development of molecular genetics, both as a self-contained field and as a body of techniques broadly useful in biologic investigation, has had a profound…”
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Detection of Microbial Nucleic Acids for Diagnostic Purposes
Published in Annual review of medicine (1992)“…The last decade has seen an explosion of interest in the use of molecular genetic techniques to diagnose infectious diseases. Specific molecular probes have…”
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The Clinical Relevance and Correct Designation of Isolates Nonsusceptible to Daptomycin
Published in Clinical infectious diseases (01-08-2005)Get full text
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Daptomycin Versus Ciprofloxacin in the Treatment of Complicated Urinary Tract Infection Due to Gram-positive Bacteria
Published in Infectious diseases in clinical practice (Baltimore, Md.) (01-11-2004)“…BACKGROUND:Complicated urinary tract infections (UTIs) due to Gram-positive pathogens are of increasing concern because of steadily emerging resistance to…”
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Phase Variation of Type 1 Fimbriae in Escherichia coli is under Transcriptional Control
Published in Science (American Association for the Advancement of Science) (16-10-1981)“…An operon fusion of the lac genes to those required for synthesis of type 1 fimbriae (pili) has been achieved in a K12 strain of Escherichia coli lysogenized…”
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Impact of Antibiotic Resistance on the Treatment of Gram-negative Sepsis
Published in Current infectious disease reports (01-10-2000)“…Resistance among gram-negative organisms has greatly complicated the care of the septic patient. An understanding of the likely source of infection, the…”
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New Opportunistic Infections — More Opportunities
Published in The New England journal of medicine (06-12-1990)“…Many of the infectious diseases that occur in patients with the acquired immunodeficiency syndrome (AIDS) are caused by common pathogenic microbes, such as…”
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Human tissue research in the genomic era of medicine: balancing individual and societal interests
Published in Archives of internal medicine (1960) (11-12-2000)“…Advances in DNA sequencing technology and in our understanding of the human genome are ushering in a new era of genomic medicine, one with dramatic potential…”
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