Search Results - "Eisenman, R"

Deconstructing myc by Eisenman, R N

“…Although myc was among the very earliest oncogenes identified and the subject of intense study, it has nonetheless proven to be an enduring enigma. To a large…”
Get full text

THE MYC/MAX/MAD NETWORK AND THE TRANSCRIPTIONAL CONTROL OF CELL BEHAVIOR by Grandori, Carla, Cowley, Shaun M, James, Leonard P, Eisenman, Robert N

“…The Myc/Max/Mad network comprises a group of transcription factors whose distinct interactions result in gene-specific transcriptional activation or…”
Get full text

Transcriptional repression by the methyl-CpG-binding protein MeCP2 involves a histone deacetylase complex by Bird, Adrian, Nan, Xinsheng, Ng, Huck-Hui, Johnson, Colin A, Laherty, Carol D, Turner, Bryan M, Eisenman, Robert N

“…Cytosine residues in the sequence 5′CpG (cytosine-guanine) are often postsynthetically methylated in animal genomes. CpG methylation is involved in long-term…”
Get full text

A complex containing N-CoR, mSin3 and histone deacetylase mediates transcriptional repression by HEINZEL, T, LAVINSKY, R. M, SETO, E, EISENMAN, R. N, ROSE, D. W, GLASS, C. K, ROSENFELD, M. G, MULLEN, T.-M, SÖDERSTRÖM, M, LAHERTY, C. D, TORCHIA, J, YANG, W.-M, BRARD, G, NGO, S. D, DAVIE, J. R

“…Transcriptional repression by nuclear receptors has been correlated to binding of the putative co-repressor, N-CoR. A complex has been identified that contains…”
Get full text

Histone Sumoylation Is Associated with Transcriptional Repression by Shiio, Yuzuru, Eisenman, Robert N.

“…Histone proteins are subject to modifications, such as acetylation, methylation, phosphorylation, ubiquitination, glycosylation, and ADP ribosylation, some of…”
Get full text

Dual regulation of Myc by Abl by Sanchez-Arévalo Lobo, V J, Doni, M, Verrecchia, A, Sanulli, S, Fagà, G, Piontini, A, Bianchi, M, Conacci-Sorrell, M, Mazzarol, G, Peg, V, Losa, J H, Ronchi, P, Ponzoni, M, Eisenman, R N, Doglioni, C, Amati, B

“…The tyrosine kinase c-Abl (or Abl) and the prolyl-isomerase Pin1 cooperatively activate the transcription factor p73 by enhancing recruitment of the…”
Get full text

The Fbw7 Tumor Suppressor Regulates Glycogen Synthase Kinase 3 Phosphorylation-Dependent c-Myc Protein Degradation by Welcker, Markus, Orian, Amir, Jin, Jianping, Grim, Jonathan A., Harper, J. Wade, Eisenman, Robert N., Clurman, Bruce E.

“…Myc proteins regulate cell growth and division and are implicated in a wide range of human cancers. We show here that Fbw7, a component of the SCFFbw7ubiquitin…”
Get full text

Max: A Helix-Loop-Helix Zipper Protein That Forms a Sequence-Specific DNA-Binding Complex with Myc by Blackwood, Elizabeth M., Eisenman, Robert N.

“…The myc protooncogene family has been implicated in cell proliferation, differentiation, and neoplasia, but its mechanism of function at the molecular level is…”
Get full text

N-myc is essential during neurogenesis for the rapid expansion of progenitor cell populations and the inhibition of neuronal differentiation by Knoepfler, Paul S, Cheng, Pei Feng, Eisenman, Robert N

“…To address the role of N-myc in neurogenesis and in nervous system tumors, it was conditionally disrupted in neuronal progenitor cells (NPCs) with a nestin-Cre…”
Get full text

Narratives of Racially/Ethnically Diverse Genderqueer & Non-binary Identities in the U.S. Context of Transnormativity and Whiteness by Eisenman, Sarah R., Rogers, Leoandra Onnie

“…Genderqueer and non-binary (GQNB) people are increasingly recognized within the gender-diverse community, yet how they navigate the sociocultural constructions…”
Get full text

Human Sin3 deacetylase and trithorax-related Set1/Ash2 histone H3-K4 methyltransferase are tethered together selectively by the cell-proliferation factor HCF-1 by Wysocka, Joanna, Myers, Michael P, Laherty, Carol D, Eisenman, Robert N, Herr, Winship

“…The abundant and chromatin-associated protein HCF-1 is a critical player in mammalian cell proliferation as well as herpes simplex virus (HSV) transcription…”
Get full text

Direct activation of RNA polymerase III transcription by c-Myc by Eisenman, Robert N, White, Robert J, Gomez-Roman, Natividad, Grandori, Carla

“…The proto-oncogene product c-Myc has a direct role in both metazoan cell growth and division. RNA polymerase III (pol III) is involved in the generation of…”
Get full text

A switch from Myc:Max to Mad:Max heterocomplexes accompanies monocyte/macrophage differentiation by AYER, D. E, EISENMAN, R. N

“…Mad is a basic-helix-loop-helix-zipper protein that heterodimerizes with Max in vitro. Mad:Max heterodimers recognize the same E-box-related DNA-binding sites…”
Get full text

Exploring Whether and How Black and White Parents Talk With Their Children About Race: M(ai)cro Race Conversations About Black Lives Matter by Rogers, Leoandra Onnie, Scott, Katharine E., Wintz, Finn, Eisenman, Sarah R., Dorsi, Chiara, Chae, David, Meltzoff, Andrew N.

“…Previous research on parent-led race conversations reports robust racial differences in the content of race conversations between Black and white parents. It…”
Get full text

Believing is seeing - the deceptive influence of bias in quantitative microscopy by Lee, Rachel M, Eisenman, Leanna R, Khuon, Satya, Aaron, Jesse S, Chew, Teng-Leong

“…The visual allure of microscopy makes it an intuitively powerful research tool. Intuition, however, can easily obscure or distort the reality of the…”
Get full text

Binding of myc proteins to canonical and noncanonical DNA sequences by BLACKWELL, T. K, JING HUANG, AVERIL MA, KRETZNER, L, ALT, F. W, EISENMAN, R. N, WEINTRAUB, H

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
Get full text

Expression Analysis with Oligonucleotide Microarrays Reveals That MYC Regulates Genes Involved in Growth, Cell Cycle, Signaling, and Adhesion by Coller, Hilary A., Grandori, Carla, Tamayo, Pablo, Colbert, Trent, Lander, Eric S., Eisenman, Robert N., Golub, Todd R.

“…MYC affects normal and neoplastic cell proliferation by altering gene expression, but the precise pathways remain unclear. We used oligonucleotide microarray…”
Get full text

Myc‐Max heterodimers activate a DEAD box gene and interact with multiple E box‐related sites in vivo by Grandori, C., Mac, J., Siëbelt, F., Ayer, D. E., Eisenman, R. N.

“…The c‐Myc protein is involved in cell proliferation, differentiation and apoptosis though heterodimerization with Max to form a transcriptionally active…”
Get full text

Drosophila myc Regulates Cellular Growth during Development by Johnston, Laura A., Prober, David A., Edgar, Bruce A., Eisenman, Robert N., Gallant, Peter

“…Transcription factors of the Myc proto-oncogene family promote cell division, but how they do this is poorly understood. Here we address the functions of…”
Get full text

Myc and Max proteins possess distinct transcriptional activities by Kretzner, Leo, Blackwood, Elizabeth M, Eisenman, Robert N

“…The Myc family proteins are thought to be involved in transcription because they have both a carboxy-terminal basic-helix-loop-helix-zipper (bHLH-Z) domain,…”
Get full text