Search Results - "Eisenhandler, Roy"

Comparative effects of fibrates on drug metabolizing enzymes in human hepatocytes by Prueksaritanont, Thomayant, Richards, Karen M, Qiu, Yue, Strong-Basalyga, Kristine, Miller, Alisha, Li, Chunze, Eisenhandler, Roy, Carlini, Edward J

“…The induction potential of different fibric acid derivatives on human drug metabolizing enzymes was evaluated to help assess the role of enzyme induction on…”
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Prediction of Metabolic Clearance for Low-Turnover Compounds Using Plated Hepatocytes with Enzyme Activity Correction by Ma, Bennett, Eisenhandler, Roy, Kuo, Yuhsin, Rearden, Paul, Li, Ying, Manley, Peter J., Smith, Sheri, Menzel, Karsten

“…Background and Objectives Prediction of metabolic clearance has been a challenge for compounds exhibiting minimal turnover in typical in vitro stability…”
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Lack of a Clinically Meaningful Pharmacokinetic Effect of Rifabutin on Raltegravir: In Vitro/In Vivo Correlation by Brainard, Diana M., Kassahun, Kelem, Wenning, Larissa A., Petry, Amelia S., Liu, Chengcheng, Lunceford, Jared, Hariparsad, Niresh, Eisenhandler, Roy, Norcross, Alisha, DeNoia, Emanuel P., Stone, Julie A., Wagner, John A., Iwamoto, Marian

“…Raltegravir is an HIV‐1 integrase strand transfer inhibitor with potent activity against HIV‐1. A prior investigation of raltegravir coadministered with…”
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siRNA-Mediated Knockdown of P450 Oxidoreductase in Rats: A Tool to Reduce Metabolism by CYPs and Increase Exposure of High Clearance Compounds by Burke, Rob S., Somasuntharam, Inthirai, Rearden, Paul, Brown, Duncan, Deshmukh, Sujal V., DiPietro, Martha A., DiMuzio, Jillian, Eisenhandler, Roy, Fauty, Scott E., Gibson, Christopher, Gindy, Marian E., Hamilton, Kelly A., Knemeyer, Ian, Koeplinger, Kenneth A., Kwon, Hae Won, Lifsted, Traci Q., Menzel, Karsten, Patel, Mihir, Pudvah, Nicole, Rudd, Deanne Jackson, Seitzer, Jessica, Strapps, Walter R., Prueksaritanont, Thomayant, Thompson, Charles D., Hochman, Jerome H., Carr, Brian A.

“…ABSTRACT Purpose To develop a tool based on siRNA-mediated knockdown of hepatic P450 oxidoreductase (POR) to decrease the CYP-mediated metabolism of small…”
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CYP2C75-involved autoinduction of metabolism in rhesus monkeys of methyl 3-chloro-3'-fluoro-4'-{(1R)-1-[({1-[(trifluoroacetyl)amino]cyclopropyl}carbonyl)amino]ethyl}-1,1'-biphenyl-2-carboxylate (MK-0686), a bradykinin B1 receptor antagonist by Tang, Cuyue, Carr, Brian A, Poignant, Frédéric, Ma, Bennett, Polsky-Fisher, Stacey L, Kuo, Yuhsin, Strong-Basalyga, Kristie, Norcross, Alisha, Richards, Karen, Eisenhandler, Roy, Carlini, Edward J, Di Marco, Christina Ng, Kuduk, Scott D, Yu, Nathan X, Raab, Conrad E, Rushmore, Tom, Frederick, Clay B, Bock, Mark G, Prueksaritanont, Thomayant

“…After oral treatment (once daily) for 4 weeks with the potent bradykinin B(1) receptor antagonist methyl…”
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Development and characterization of LLC-PK1 cells containing Sprague–Dawley rat Abcb1a ( Mdr1a): Comparison of rat P-glycoprotein transport to human and mouse by Booth-Genthe, Catherine L., Louie, Steven W., Carlini, Edward J., Li, Bing, Leake, Brenda F., Eisenhandler, Roy, Hochman, Jerome H., Mei, Qin, Kim, Richard B., Rushmore, Thomas H., Yamazaki, Masayo

“…P-glycoprotein is localized in numerous tissues throughout the body and plays an important role in the disposition of many xenobiotics. The contribution of…”
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Determination of famotidine in low-volume human plasma by normal-phase liquid chromatography/tandem mass spectrometry by Zhong, Ling, Eisenhandler, Roy, Yeh, Kuang C.

“…A rapid, sensitive and robust assay procedure using liquid chromatography coupled with tandem mass spectrometry (LC/MS/MS) for the determination of famotidine…”
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Pharmacokinetics of famotidine in infants by WENNING, Larissa A, MURPHY, M. Gail, YEH, Kuang C, KEARNS, Gregory L, JAMES, Laura P, BLUMER, Jeffrey L, MARSHALL, James D, BAIER, John, SCHEIMANN, Ann, PANEBIANCO, Deborah L, LING ZHONG, EISENHANDLER, Roy

“…Although famotidine pharmacokinetics are similar in adults and children older than 1 year of age, they differ in neonates owing to developmental immaturity in…”
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Growth hormone response in man to L-692,429, a novel nonpeptide mimic of growth hormone-releasing peptide-6 by Gertz, B J, Barrett, J S, Eisenhandler, R, Krupa, D A, Wittreich, J M, Seibold, J R, Schneider, S H

“…L-692,429, a substituted benzolactam, is a novel nonpeptide mimic of the GH secretagogue, GH-releasing peptide-6. The safety and GH secretory activity of…”
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