Search Results - "Eisenbarth, George"

Type 1 diabetes by Atkinson, Mark A, Prof, Eisenbarth, George S, Prof, Michels, Aaron W, MD

“…Summary Over the past decade, knowledge of the pathogenesis and natural history of type 1 diabetes has grown substantially, particularly with regard to disease…”
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Genetics, pathogenesis and clinical interventions in type 1 diabetes by Herold, Kevan, Bluestone, Jeffrey A, Eisenbarth, George

“…Type 1 diabetes is an autoimmune disorder afflicting millions of people worldwide. Once diagnosed, patients require lifelong insulin treatment and can…”
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Seroconversion to Multiple Islet Autoantibodies and Risk of Progression to Diabetes in Children by Ziegler, Anette G, Rewers, Marian, Simell, Olli, Simell, Tuula, Lempainen, Johanna, Steck, Andrea, Winkler, Christiane, Ilonen, Jorma, Veijola, Riitta, Knip, Mikael, Bonifacio, Ezio, Eisenbarth, George S

“…IMPORTANCE Type 1 diabetes usually has a preclinical phase identified by circulating islet autoantibodies, but the rate of progression to diabetes after…”
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Banting Lecture 2009: An Unfinished Journey: Molecular Pathogenesis to Prevention of Type 1A Diabetes by EISENBARTH, George S

“…The Banting Medal for Scientific Achievement Award is the American Diabetes Association's highest scientific award and honors an individual who has made…”
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UPDATE : Update in type 1 diabetes by EISENBARTH, George S

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Update in Type 1 Diabetes by Eisenbarth, George S.

“…Context: Type 1 diabetes is a heterogeneous disorder characterized by severe β-cell loss. The great majority of patients have type 1A or immune-mediated…”
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Risk of Pediatric Celiac Disease According to HLA Haplotype and Country by Liu, Edwin, Lee, Hye-Seung, Aronsson, Carin A, Hagopian, William A, Koletzko, Sibylle, Rewers, Marian J, Eisenbarth, George S, Bingley, Polly J, Bonifacio, Ezio, Simell, Ville, Agardh, Daniel

“…In this cohort study involving 6403 children at increased risk for celiac disease on the basis of HLA haplotype, the risks of celiac disease autoimmunity and…”
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The Cation Efflux Transporter ZnT8 (Slc30A8) Is a Major Autoantigen in Human Type 1 Diabetes by Wenzlau, Janet M., Juhl, Kirstine, Yu, Liping, Moua, Ong, Sarkar, Suparna A., Gottlieb, Peter, Rewers, Marian, Eisenbarth, George S., Jensen, Jan, Davidson, Howard W., Hutton, John C.

“…Type 1 diabetes (T1D) results from progressive loss of pancreatic islet mass through autoimmunity targeted at a diverse, yet limited, series of molecules that…”
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Infant exposures and development of type 1 diabetes mellitus: The Diabetes Autoimmunity Study in the Young (DAISY) by Frederiksen, Brittni, Kroehl, Miranda, Lamb, Molly M, Seifert, Jennifer, Barriga, Katherine, Eisenbarth, George S, Rewers, Marian, Norris, Jill M

“…The incidence of type 1 diabetes mellitus (T1DM) is increasing worldwide, with the most rapid increase among children younger than 5 years of age. To examine…”
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Molecular Targeting of Islet Autoantigens by Stadinski, Brian, Kappler, John, Eisenbarth, George S.

“…Type 1 diabetes of man and animal models results from immune-mediated specific beta cell destruction. Multiple islet antigens are targets of autoimmunity and…”
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Immunologic endocrine disorders by Michels, Aaron W., MD, Eisenbarth, George S., MD, PhD

“…Autoimmunity affects multiple glands in the endocrine system. Animal models and human studies highlight the importance of alleles in HLA-like molecules…”
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Specificity and detection of insulin-reactive CD4⁺ T cells in type 1 diabetes in the nonobese diabetic (NOD) mouse by Crawford, Frances, Stadinski, Brian, Jin, Niyun, Michels, Aaron, Nakayama, Maki, Pratt, Philip, Marrack, Philippa, Eisenbarth, George, Kappler, John W.

“…In the nonobese diabetic (NOD) mouse model of type 1 diabetes (T1D), an insulin peptide (B:9-23) is a major target for pathogenic CD4⁺ T cells. However, there…”
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Harmonization of Glutamic Acid Decarboxylase and Islet Antigen-2 Autoantibody Assays for National Institute of Diabetes and Digestive and Kidney Diseases Consortia by Bonifacio, Ezio, Yu, Liping, Williams, Alastair K., Eisenbarth, George S., Bingley, Polly J., Marcovina, Santica M., Adler, Kerstin, Ziegler, Anette G., Mueller, Patricia W., Schatz, Desmond A., Krischer, Jeffrey P., Steffes, Michael W., Akolkar, Beena

“…Background/Rationale: Autoantibodies to islet antigen-2 (IA-2A) and glutamic acid decarboxylase (GADA) are markers for diagnosis, screening, and measuring…”
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Type 1 diabetes: new perspectives on disease pathogenesis and treatment by Atkinson, Mark A, Eisenbarth, George S

“…As our knowledge of type 1 (insulin-dependent) diabetes increases, so does our appreciation for the pathogenic complexity of this disease and the challenges…”
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How Does Type 1 Diabetes Develop?: The Notion of Homicide or β-Cell Suicide Revisited by ATKINSON, Mark A, BLUESTONE, Jeffrey A, RHODES, Christopher J, EISENBARTH, George S, HEBROK, Matthias, HEROLD, Kevan C, ACCILI, Domenico, PIETROPAOLO, Massimo, ARVAN, Peter R, VON HERRATH, Matthias, MARKEL, Dorene S

“…Despite decades of acknowledging that a loss of insulin-producing pancreatic β-cells is central to the disorder now referred to as type 1 diabetes, the…”
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Enterovirus Infection and Progression From Islet Autoimmunity to Type 1 Diabetes: The Diabetes and Autoimmunity Study in the Young (DAISY) by STENE, Lars C, OIKARINEN, Sami, HYOTY, Heikki, BARRIGA, Katherine J, NORRIS, Jill M, KLINGENSMITH, Georgeanna, HUTTON, John C, ERLICH, Henry A, EISENBARTH, George S, REWERS, Marian

“…To investigate whether enterovirus infections predict progression to type 1 diabetes in genetically predisposed children repeatedly positive for islet…”
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GAD65 Autoantibodies Detected by Electrochemiluminescence Assay Identify High Risk for Type 1 Diabetes by DONGMEI MIAO, GUYER, K. Michelle, FRAN DONG, LING JIANG, STECK, Andrea K, REWERS, Marian, EISENBARTH, George S, LIPING YU

“…The identification of diabetes-relevant islet autoantibodies is essential for predicting and preventing type 1 diabetes (T1D). The aim of the current study was…”
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A Common Nonsynonymous Single Nucleotide Polymorphism in the SLC30A8 Gene Determines ZnT8 Autoantibody Specificity in Type 1 Diabetes by Wenzlau, Janet M, Liu, Yu, Yu, Liping, Moua, Ong, Fowler, Kimberly T, Rangasamy, Sampathkumar, Walters, Jay, Eisenbarth, George S, Davidson, Howard W, Hutton, John C

“…A Common Nonsynonymous Single Nucleotide Polymorphism in the SLC30A8 Gene Determines ZnT8 Autoantibody Specificity in Type 1 Diabetes Janet M. Wenzlau 1 , Yu…”
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Distinguishing Persistent Insulin Autoantibodies With Differential Risk: Nonradioactive Bivalent Proinsulin/Insulin Autoantibody Assay by LIPING YU, DONGMEI MIAO, SCRIMGEOUR, Laura, JOHNSON, Kelly, REWERS, Marian, EISENBARTH, George S

“…A subset of children develops persistent insulin autoantibodies (IAA; almost always as the only islet autoantibody) without evidence of progression to…”
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Timing of Initial Exposure to Cereal Grains and the Risk of Wheat Allergy by Poole, Jill A, Barriga, Kathy, Leung, Donald Y.M, Hoffman, Michelle, Eisenbarth, George S, Rewers, Marian, Norris, Jill M

“…Early exposure to solid foods in infancy has been associated with the development of allergy. The aim of this study was to examine the association between…”
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