Search Results - "Eisenbarth, G."

Type 1 diabetes: new perspectives on disease pathogenesis and treatment by Atkinson, Mark A, Eisenbarth, George S

“…As our knowledge of type 1 (insulin-dependent) diabetes increases, so does our appreciation for the pathogenic complexity of this disease and the challenges…”
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Dimorphic histopathology of long-standing childhood-onset diabetes by Gianani, R, Campbell-Thompson, M, Sarkar, S. A, Wasserfall, C, Pugliese, A, Solis, J. M, Kent, S. C, Hering, B. J, West, E, Steck, A, Bonner-Weir, S, Atkinson, M. A, Coppieters, K, von Herrath, M, Eisenbarth, G. S

“…Aims/hypothesis Childhood diabetes is thought to usually result from autoimmune beta cell destruction (type 1A) with eventual total loss of beta cells…”
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No association of vitamin D intake or 25-hydroxyvitamin D levels in childhood with risk of islet autoimmunity and type 1 diabetes: the Diabetes Autoimmunity Study in the Young (DAISY) by Simpson, M., Brady, H., Yin, X., Seifert, J., Barriga, K., Hoffman, M., Bugawan, T., Barón, A. E., Sokol, R. J., Eisenbarth, G., Erlich, H., Rewers, M., Norris, J. M.

“…Aims/hypothesis The aim of the study was to investigate the association between vitamin D intake and status and the risk of islet autoimmunity (IA) and…”
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Interferon alpha—a potential link in the pathogenesis of viral-induced type 1 diabetes and autoimmunity by Devendra, D, Eisenbarth, G.S

“…The incidence of type 1 diabetes has been rapidly rising. Environmental factors such as viruses have been implicated as a possible agent accounting for this…”
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Genetic control of autoimmunity in Type I diabetes and associated disorders by REDONDO, M. J, EISENBARTH, G. S

“…Type I (insulin-dependent) diabetes mellitus is a heterogeneous disease with major subdivisions termed Type 1A (immune-mediated) and Type 1B. Immune-mediated…”
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Kinetics of the Post-Onset Decline in Zinc Transporter 8 Autoantibodies in Type 1 Diabetic Human Subjects by Wenzlau, J. M, Walter, M, Gardner, T. J, Frisch, L. M, Yu, L, Eisenbarth, G. S, Ziegler, A.-G, Davidson, H. W, Hutton, J. C

“…Context: Zinc transporter 8 (ZnT8) is a newly discovered islet autoantigen in human type 1A diabetes (T1D). Objective: The objective was to document changes in…”
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Heterogeneity of Type I diabetes: analysis of monozygotic twins in Great Britain and the United States by REDONDO, M. J, YU, L, HAWA, M, MACKENZIE, T, PYKE, D. A, EISENBARTH, G. S, LESLIE, R. D. G

“…To determine the risk, hazard rate and factors affecting progression to diabetes in monozygotic twins of patients with Type I (insulin-dependent) diabetes…”
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Detection of four diabetes specific autoantibodies in a single radioimmunoassay: an innovative high‐throughput approach for autoimmune diabetes screening by Tiberti, C., Yu, L., Lucantoni, F., Panimolle, F., Spagnuolo, I., Lenzi, A., Eisenbarth, G. S., Dotta, F.

“…Summary Highly sensitive and specific radioimmunoassays have been validated for autoantibodies reacting with the four major autoantigens identified so far in…”
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Confirmation of novel type 1 diabetes risk loci in families by Cooper, J. D., Howson, J. M. M., Smyth, D., Walker, N. M., Stevens, H., Yang, J. H. M., She, J.-X., Eisenbarth, G. S., Rewers, M., Todd, J. A., Akolkar, B., Concannon, P., Erlich, H. A., Julier, C., Morahan, G., Nerup, J., Nierras, C., Pociot, F., Rich, S. S.

“…Aims/hypothesis Over 50 regions of the genome have been associated with type 1 diabetes risk, mainly using large case/control collections. In a recent…”
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Cellular and molecular pathogenesis of type 1A diabetes by Jahromi, M M, Eisenbarth, G S

“…Type 1A diabetes is an organ-specific autoimmune disease resulting from destruction of insulin-producing pancreatic beta-cells. The main susceptibility genes…”
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Autoimmune polyendocrine syndrome type 1 (APS‐1) as a model for understanding autoimmune polyendocrine syndrome type 2 (APS‐2) by Michels, A. W., Eisenbarth, G. S.

“… Autoimmune polyendocrine syndromes type 1 and 2 (APS‐1 and APS‐2) are diverse in regards to their component diseases and immunologic features of…”
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The HLA-B3906 allele imparts a high risk of diabetes only on specific HLA-DR/DQ haplotypes by Baschal, E. E., Baker, P. R., Eyring, K. R., Siebert, J. C., Jasinski, J. M., Eisenbarth, G. S.

“…Aims/hypothesis We investigated the risk associated with HLA-B * 39 alleles in the context of specific HLA-DR/DQ haplotypes. Methods We studied a readily…”
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Investigation of the vitamin D receptor gene (VDR) and its interaction with protein tyrosine phosphatase, non-receptor type 2 gene (PTPN2) on risk of islet autoimmunity and type 1 diabetes: The Diabetes Autoimmunity Study in the Young (DAISY) by Frederiksen, B., Liu, E., Romanos, J., Steck, A.K., Yin, X., Kroehl, M., Fingerlin, T.E., Erlich, H., Eisenbarth, G.S., Rewers, M., Norris, J.M.

“…► We investigated the association between T1D and variants in VDR and PTPN2 genes. ► VDR and PTPN2 variants are not associated with risk of development of IA…”
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Combined use of autoantibodies (IA-2 autoantibody, GAD autoantibody, insulin autoantibody, cytoplasmic islet cell antibodies) in type 1 diabetes: Combinatorial Islet Autoantibody Workshop by VERGE, C. F, STENGER, D, BONIFACIO, E, COLMAN, P. G, PILCHER, C, BINGLEY, P. J, EISENBARTH, G. S

“…Combined use of autoantibodies (IA-2 autoantibody, GAD autoantibody, insulin autoantibody, cytoplasmic islet cell antibodies) in type 1 diabetes: Combinatorial…”
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Antigen-dependent immunotherapy of non-obese diabetic mice with immature dendritic cells by Haase, C, Yu, L, Eisenbarth, G, Markholst, H

“…Immunotherapy can be used to induce immunological tolerance by a number of different protocols. During the last decade the ability to use tolerogenic dendritic…”
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Prediction of type I diabetes in first-degree relatives using a combination of insulin, GAD, and ICA512bdc/IA-2 autoantibodies by Verge, C. F., Gianani, R., Kawasaki, E., Yu, L., Pietropaolo, M., Jackson, R. A., Chase, H. P., Eisenbarth, G. S.

“…Prediction of type I diabetes in first-degree relatives using a combination of insulin, GAD, and ICA512bdc/IA-2 autoantibodies. C F Verge , R Gianani , E…”
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The insulin gene is transcribed in the human thymus and transcription levels correlate with allelic variation at the INS VNTR- IDDM2 susceptibility locus for type 1 diabetes by Pugliese, Alberto, Zeller, Markus, Fernandez, Alarico, Zalcberg, Laura J, Bartlett, Richard J, Ricordi, Camillo, Pietropaolo, Massimo, Eisenbarth, George S, Bennett, Simon T, Patel, Dhavalkumar D

“…Type 1, or insulin-dependent diabetes mellitus (IDDM) is an autoimmune disease associated with loss of tolerance to several pancreatic islet cell molecules,…”
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Initial Results of Screening of Nondiabetic Organ Donors for Expression of Islet Autoantibodies by Gianani, R., Putnam, A., Still, T., Yu, L., Miao, D., Gill, R. G., Beilke, J., Supon, P., Valentine, A., Iveson, A., Dunn, S., Eisenbarth, G. S., Hutton, J., Gottlieb, P., Wiseman, A.

“…Context: Type 1A diabetes is characterized by a long prodromal phase during which autoantibodies to islet antigens are present. Nevertheless, we lack data on…”
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A functional variant of lymphoid tyrosine phosphatase is associated with type I diabetes by Comings, David, Nika, Konstantina, Bottini, Nunzio, Musumeci, Lucia, Meloni, Gian Franco, Rahmouni, Souad, Lucarelli, Paola, Pellecchia, Maurizio, Mustelin, Tomas, Eisenbarth, George S, MacMurray, James, Alonso, Andres, Rostamkhani, Masoud

“…We report that a single-nucleotide polymorphism (SNP) in the gene (PTPN22) encoding the lymphoid protein tyrosine phosphatase (LYP), a suppressor of T-cell…”
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Newborn screening for HLA markers associated with IDDM : Diabetes Autoimmunity Study in the Young (DAISY) by REWERS, M, BUGAWAN, T. L, ERLICH, H. A, NORRIS, J. M, BLAIR, A, BEATY, B, HOFFMAN, M, MCDUFFIE, R. S, HAMMAN, R. F, KLINGENSMITH, G, EISENBARTH, G. S

“…Autoimmunity causing insulin-dependent diabetes mellitus (IDDM) begins in early childhood due to interactions between genes and unknown environmental factors…”
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