Search Results - "Eiselt, Emilie"

Use of a Noninvasive Brain-Penetrating Peptide-Drug Conjugate Strategy to Improve the Delivery of Opioid Pain Relief Medications to the Brain by Eiselt, Émilie, Otis, Valérie, Belleville, Karine, Yang, Gaoqiang, Larocque, Alain, Régina, Anthony, Demeule, Michel, Sarret, Philippe, Gendron, Louis

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Tweak regulates astrogliosis, microgliosis and skeletal muscle atrophy in a mouse model of amyotrophic lateral sclerosis by Bowerman, Melissa, Salsac, Céline, Coque, Emmanuelle, Eiselt, Émilie, Deschaumes, Roman G, Brodovitch, Alexandre, Burkly, Linda C, Scamps, Frédérique, Raoul, Cédric

“…Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder that primarily affects motoneurons in the brain and spinal cord. Astrocyte and…”
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Optimized Opioid-Neurotensin Multitarget Peptides: From Design to Structure–Activity Relationship Studies by Gonzalez, Simon, Dumitrascuta, Maria, Eiselt, Emilie, Louis, Stevany, Kunze, Linda, Blasiol, Annalisa, Vivancos, Mélanie, Previti, Santo, Dewolf, Elke, Martin, Charlotte, Tourwé, Dirk, Cavelier, Florine, Gendron, Louis, Sarret, Philippe, Spetea, Mariana, Ballet, Steven

“…Fusion of nonopioid pharmacophores, such as neurotensin, with opioid ligands represents an attractive approach for pain treatment. Herein, the μ-/δ-opioid…”
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The combination of opioid and neurotensin receptor agonists improves their analgesic/adverse effect ratio by Eiselt, Emilie, Côté, Jérôme, Longpré, Jean-Michel, Blais, Véronique, Sarret, Philippe, Gendron, Louis

“…Opioid and neurotensin (NT) receptors are expressed in both central and peripheral nervous systems where they modulate nociceptive responses. Nowadays, opioid…”
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Neurotensin Analogues Containing Cyclic Surrogates of Tyrosine at Position 11 Improve NTS2 Selectivity Leading to Analgesia without Hypotension and Hypothermia by Eiselt, Emilie, Gonzalez, Simon, Martin, Charlotte, Chartier, Magali, Betti, Cecilia, Longpré, Jean-Michel, Cavelier, Florine, Tourwé, Dirk, Gendron, Louis, Ballet, Steven, Sarret, Philippe

“…Neurotensin (NT) exerts its analgesic effects through activation of the G protein-coupled receptors NTS1 and NTS2. This opioid-independent antinociception…”
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Corrigendum to “Chemical space screening around Phe3 in opioid peptides: Modulating µ versus δ agonism by Suzuki-Miyaura cross-couplings” [Bioorg. Med. Chem. Lett. 28(13) (2018) 2320–2323] by Willemse, Tom, Eiselt, Emilie, Hollanders, Karlijn, Schepens, Wim, van Vlijmen, Herman W.T., Chung, Nga N., Blais, Véronique, Holleran, Brian, Longpré, Jean-Michel, Schiller, Peter W., Maes, Bert U.W., Sarret, Philippe, Gendron, Louis, Ballet, Steven

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Chemical space screening around Phe3 in opioid peptides: Modulating µ versus δ agonism by Suzuki-Miyaura cross-couplings by Willemse, Tom, Eiselt, Emilie, Hollanders, Karlijn, Schepens, Wim, van Vlijmen, Herman W.T., Chung, Nga N., Blais, Véronique, Holleran, Brain, Longpré, Jean-Michel, Schiller, Peter W., Maes, Bert U.W., Sarret, Philippe, Gendron, Louis, Ballet, Steven

“…[Display omitted] •Dmt-dermorphin[1–4] analogs were tested at the opioid receptors.•Solid-phase and solution-phase Suzuki-Miyaura cross-couplings.•Chemical…”
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Use of a non-invasive brain penetrating peptide-drug conjugate strategy to improve the delivery of opioid pain relief medications to the brain by Eiselt, Emilie, Otis, Valerie, Belleville, Karine, Yang, Gaoqiang, Larocque, Alain, Regina, Anthony, Demeule, Michel, Sarret, Philippe, Gendron, Louis

“…The analgesic potency of morphine-6-glucuronide (M6G) has been shown to be 50-fold higher than morphine after intracerebral injection. However, the brain…”
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χ‑Space Screening of Dermorphin-Based Tetrapeptides through Use of Constrained Arylazepinone and Quinolinone Scaffolds by Van der Poorten, Olivier, Van Den Hauwe, Robin, Eiselt, Emilie, Betti, Cecilia, Guillemyn, Karel, Chung, Nga N, Hallé, François, Bihel, Frédéric, Schiller, Peter W, Tourwé, Dirk, Sarret, Philippe, Gendron, Louis, Ballet, Steven

“…Herein, the synthesis of novel conformationally constrained amino acids, 4-amino-8-bromo-2-benzazepin-3-one (8-Br-Aba), 3-amino-3,4-dihydroquinolin-2-one, and…”
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Corrigendum to "Chemical space screening around Phe 3 in opioid peptides: Modulating µ versus δ agonism by Suzuki-Miyaura cross-couplings" [Bioorg. Med. Chem. Lett. 28(13) (2018) 2320-2323] by Willemse, Tom, Eiselt, Emilie, Hollanders, Karlijn, Schepens, Wim, van Vlijmen, Herman W T, Chung, Nga N, Blais, Véronique, Holleran, Brian, Longpré, Jean-Michel, Schiller, Peter W, Maes, Bert U W, Sarret, Philippe, Gendron, Louis, Ballet, Steven

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Chemical space screening around Phe 3 in opioid peptides: Modulating µ versus δ agonism by Suzuki-Miyaura cross-couplings by Willemse, Tom, Eiselt, Emilie, Hollanders, Karlijn, Schepens, Wim, van Vlijmen, Herman W T, Chung, Nga N, Blais, Véronique, Holleran, Brain, Longpré, Jean-Michel, Schiller, Peter W, Maes, Bert U W, Sarret, Philippe, Gendron, Louis, Ballet, Steven

“…In this study, affinities and activities of derivatized analogues of Dmt-dermorphin[1-4] (i.e. Dmt-d-Ala-Phe-GlyNH , Dmt = 2',6'-dimethyl-(S)-tyrosine) for the…”
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The P2Y 6 receptor signals through Gα q /Ca 2+ /PKCα and Gα 13 /ROCK pathways to drive the formation of membrane protrusions and dictate cell migration by Girard, Mélissa, Dagenais Bellefeuille, Steve, Eiselt, Émilie, Brouillette, Rebecca, Placet, Morgane, Arguin, Guillaume, Longpré, Jean-Michel, Sarret, Philippe, Gendron, Fernand-Pierre

“…Cell migration is a ubiquitous process necessary to maintain and restore tissue functions. However, in cancer, cell migration leads to metastasis development…”
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The P2Y6 receptor signals through Gαq/Ca2+/PKCα and Gα13/ROCK pathways to drive the formation of membrane protrusions and dictate cell migration by Girard, Mélissa, Dagenais Bellefeuille, Steve, Eiselt, Émilie, Brouillette, Rebecca, Placet, Morgane, Arguin, Guillaume, Longpré, Jean‐Michel, Sarret, Philippe, Gendron, Fernand‐Pierre

“…Cell migration is a ubiquitous process necessary to maintain and restore tissue functions. However, in cancer, cell migration leads to metastasis development…”
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Ligand-dependent intracellular trafficking of the G protein-coupled P2Y 6 receptor by Girard, Mélissa, Bellefeuille, Steve Dagenais, Eiselt, Émilie, Arguin, Guillaume, Longpré, Jean-Michel, Sarret, Philippe, Gendron, Fernand-Pierre

“…Endosomal trafficking is intricately linked to G protein-coupled receptors (GPCR) fate and signaling. Extracellular uridine diphosphate (UDP) acts as a…”
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