Search Results - "Eischen, M."

Decoding critical long non-coding RNA in ovarian cancer epithelial-to-mesenchymal transition by Mitra, Ramkrishna, Chen, Xi, Greenawalt, Evan J., Maulik, Ujjwal, Jiang, Wei, Zhao, Zhongming, Eischen, Christine M.

“…Long non-coding RNA (lncRNA) are emerging as contributors to malignancies. Little is understood about the contribution of lncRNA to epithelial-to-mesenchymal…”
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Targeting the Bcl-2 Family in B Cell Lymphoma by Adams, Clare M, Clark-Garvey, Sean, Porcu, Pierluigi, Eischen, Christine M

“…Although lymphoma is a very heterogeneous group of biologically complex malignancies, tumor cells across all B cell lymphoma subtypes share a set of underlying…”
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Pan-cancer analysis reveals cooperativity of both strands of microRNA that regulate tumorigenesis and patient survival by Mitra, Ramkrishna, Adams, Clare M., Jiang, Wei, Greenawalt, Evan, Eischen, Christine M.

“…Recently, both 5p and 3p miRNA strands are being recognized as functional instead of only one, leaving many miRNA strands uninvestigated. To determine whether…”
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The Mdm Network and Its Regulation of p53 Activities: A Rheostat of Cancer Risk by Eischen, Christine M., Lozano, Guillermina

“…ABSTRACT The potent transcriptional activity of p53 (Trp53, TP53) must be kept in check for normal cell growth and survival. Tumors, which drastically deviate…”
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Role of Mdm2 and Mdmx in DNA repair by Eischen, Christine M

“…Mdm2 and Mdmx are critical regulators of the p53 tumour suppressor and are overexpressed in many human malignancies. However, in recent years, their impact on…”
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Whole-genome sequencing reveals oncogenic mutations in mycosis fungoides by McGirt, Laura Y., Jia, Peilin, Baerenwald, Devin A., Duszynski, Robert J., Dahlman, Kimberly B., Zic, John A., Zwerner, Jeffrey P., Hucks, Donald, Dave, Utpal, Zhao, Zhongming, Eischen, Christine M.

“…The pathogenesis of mycosis fungoides (MF), the most common cutaneous T-cell lymphoma (CTCL), is unknown. Although genetic alterations have been identified,…”
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Myc Induces miRNA-Mediated Apoptosis in Response to HDAC Inhibition in Hematologic Malignancies by Adams, Clare M, Hiebert, Scott W, Eischen, Christine M

“…Alterations in the expression or function of histone deacetylases (HDAC) contribute to the development and progression of hematologic malignancies…”
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Histone deacetylase inhibition reveals a tumor-suppressive function of MYC-regulated miRNA in breast and lung carcinoma by Adams, C M, Eischen, C M

“…Histone deacetylase (HDAC) inhibition leads to dynamic changes in the epigenetic landscape that is postulated to alter the expression of critical mediators of…”
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Interaction with WDR5 Promotes Target Gene Recognition and Tumorigenesis by MYC by Thomas, Lance R., Wang, Qingguo, Grieb, Brian C., Phan, Jason, Foshage, Audra M., Sun, Qi, Olejniczak, Edward T., Clark, Travis, Dey, Soumyadeep, Lorey, Shelly, Alicie, Bethany, Howard, Gregory C., Cawthon, Bryan, Ess, Kevin C., Eischen, Christine M., Zhao, Zhongming, Fesik, Stephen W., Tansey, William P.

“…MYC is an oncoprotein transcription factor that is overexpressed in the majority of malignancies. The oncogenic potential of MYC stems from its ability to bind…”
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MicroRNA-31 initiates lung tumorigenesis and promotes mutant KRAS-driven lung cancer by Edmonds, Mick D, Boyd, Kelli L, Moyo, Tamara, Mitra, Ramkrishna, Duszynski, Robert, Arrate, Maria Pia, Chen, Xi, Zhao, Zhongming, Blackwell, Timothy S, Andl, Thomas, Eischen, Christine M

“…MicroRNA (miR) are important regulators of gene expression, and aberrant miR expression has been linked to oncogenesis; however, little is understood about…”
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Systematic lncRNA mapping to genome-wide co-essential modules uncovers cancer dependency on uncharacterized lncRNAs by Mitra, Ramkrishna, Adams, Clare M, Eischen, Christine M

“…Quantification of gene dependency across hundreds of cell lines using genome-scale CRISPR screens has revealed co-essential pathways/modules and critical…”
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Myc enhances B-cell receptor signaling in precancerous B cells and confers resistance to Btk inhibition by Moyo, T K, Wilson, C S, Moore, D J, Eischen, C M

“…Dysregulation of the oncogenic transcription factor MYC induces B-cell transformation and is a driver for B-cell non-Hodgkin lymphoma (B-NHL). MYC…”
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SMARCAL1 maintains telomere integrity during DNA replication by Poole, Lisa A., Zhao, Runxiang, Glick, Gloria G., Lovejoy, Courtney A., Eischen, Christine M., Cortez, David

“…The SMARCAL1 (SWI/SNF related, matrix-associated, actin-dependent, regulator of chromatin, subfamily A-like 1) DNA translocase is one of several related…”
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MTBP and MYC: A Dynamic Duo in Proliferation, Cancer, and Aging by Grieb, Brian C, Eischen, Christine M

“…The oncogenic transcription factor c-MYC (MYC) is highly conserved across species and is frequently overexpressed or dysregulated in human cancers. MYC…”
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MYC regulates ribosome biogenesis and mitochondrial gene expression programs through its interaction with host cell factor-1 by Popay, Tessa M, Wang, Jing, Adams, Clare M, Howard, Gregory Caleb, Codreanu, Simona G, Sherrod, Stacy D, McLean, John A, Thomas, Lance R, Lorey, Shelly L, Machida, Yuichi J, Weissmiller, April M, Eischen, Christine M, Liu, Qi, Tansey, William P

“…The oncoprotein transcription factor MYC is a major driver of malignancy and a highly validated but challenging target for the development of anticancer…”
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miRcorrNet: machine learning-based integration of miRNA and mRNA expression profiles, combined with feature grouping and ranking by Yousef, Malik, Goy, Gokhan, Mitra, Ramkrishna, Eischen, Christine M, Jabeer, Amhar, Bakir-Gungor, Burcu

“…A better understanding of disease development and progression mechanisms at the molecular level is critical both for the diagnosis of a disease and for the…”
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The Role of Inhibition of Apoptosis in Acute Leukemias and Myelodysplastic Syndrome by McBride, Amanda, Houtmann, Sarah, Wilde, Lindsay, Vigil, Carlos, Eischen, Christine M, Kasner, Margaret, Palmisiano, Neil

“…Avoidance of apoptosis is a key mechanism that malignancies, including acute leukemias and MDS, utilize in order to proliferate and resist chemotherapy…”
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A roadmap of osteogenic differentiation in human mesenchymal stem cells assessed by protein multiplex analysis by Eischen-Loges, M, Tahmasebi Birgani, Z, Alaoui Selsouli, Y, Eijssen, L, Rho, H, Sthijns, M, van Griensven, M, LaPointe, V, Habibović, P

“…Human mesenchymal stem cells (hMSCs) are widely used to model osteogenic differentiation in vitro, yet few studies compare the numerous available protocols…”
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CTpathway: a CrossTalk-based pathway enrichment analysis method for cancer research by Liu, Haizhou, Yuan, Mengqin, Mitra, Ramkrishna, Zhou, Xu, Long, Min, Lei, Wanyue, Zhou, Shunheng, Huang, Yu-E, Hou, Fei, Eischen, Christine M, Jiang, Wei

“…Pathway enrichment analysis (PEA) is a common method for exploring functions of hundreds of genes and identifying disease-risk pathways. Moreover, different…”
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IL-33 Is a Cell-Intrinsic Regulator of Fitness during Early B Cell Development by Stier, Matthew T, Mitra, Ramkrishna, Nyhoff, Lindsay E, Goleniewska, Kasia, Zhang, Jian, Puccetti, Matthew V, Casanova, Holly C, Seegmiller, Adam C, Newcomb, Dawn C, Kendall, Peggy L, Eischen, Christine M, Peebles, Jr, R Stokes

“…IL-33 is an IL-1 family member protein that is a potent driver of inflammatory responses in both allergic and nonallergic disease. This proinflammatory effect…”
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