Search Results - "Eisch, J"

Depression and Hippocampal Neurogenesis: A Road to Remission? by Eisch, Amelia J., Petrik, David

“…Adult-generated hippocampal neurons are required for mood control and antidepressant efficacy, raising hopes that someday we can harness the power of new…”
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Aberrant hippocampal neurogenesis contributes to epilepsy and associated cognitive decline by Cho, Kyung-Ok, Lybrand, Zane R., Ito, Naoki, Brulet, Rebecca, Tafacory, Farrah, Zhang, Ling, Good, Levi, Ure, Kerstin, Kernie, Steven G., Birnbaum, Shari G., Scharfman, Helen E., Eisch, Amelia J., Hsieh, Jenny

“…Acute seizures after a severe brain insult can often lead to epilepsy and cognitive impairment. Aberrant hippocampal neurogenesis follows the insult but the…”
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The neurogenesis hypothesis of affective and anxiety disorders: Are we mistaking the scaffolding for the building? by Petrik, David, Lagace, Diane C., Eisch, Amelia J.

“…Hypotheses are scaffoldings erected in front of a building and then dismantled when the building is finished. They are indispensable for the workman; but you…”
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Neurod1 is essential for the survival and maturation of adult-born neurons by Hsieh, Jenny, Gao, Zhengliang, Ure, Kerstin, Ables, Jessica L, Lagace, Diane C, Nave, Klaus-Armin, Goebbels, Sandra, Eisch, Amelia J

“…The transcriptional program that controls adult neurogenesis is unknown. We generated mice with an inducible stem cell-specific deletion of Neurod1, resulting…”
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Epigenetics, hippocampal neurogenesis, and neuropsychiatric disorders: Unraveling the genome to understand the mind by Hsieh, Jenny, Eisch, Amelia J

“…Abstract In mature, differentiated neurons in the central nervous system (CNS), epigenetic mechanisms—including DNA methylation, histone modification, and…”
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Molecular Adaptations Underlying Susceptibility and Resistance to Social Defeat in Brain Reward Regions by Krishnan, Vaishnav, Han, Ming-Hu, Graham, Danielle L., Berton, Olivier, Renthal, William, Russo, Scott J., LaPlant, Quincey, Graham, Ami, Lutter, Michael, Lagace, Diane C., Ghose, Subroto, Reister, Robin, Tannous, Paul, Green, Thomas A., Neve, Rachael L., Chakravarty, Sumana, Kumar, Arvind, Eisch, Amelia J., Self, David W., Lee, Francis S., Tamminga, Carol A., Cooper, Donald C., Gershenfeld, Howard K., Nestler, Eric J.

“…While stressful life events are an important cause of psychopathology, most individuals exposed to adversity maintain normal psychological functioning. The…”
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Does chronic systemic injection of the DREADD agonists clozapine-N-oxide or Compound 21 change behavior relevant to locomotion, exploration, anxiety, and depression in male non-DREADD-expressing mice? by Tran, Fionya H., Spears, Stella L., Ahn, Kyung J., Eisch, Amelia J., Yun, Sanghee

“…•Acute injection of CNO changes behavior of non-DREADD-expressing mice.•It’s not known if chronic CNO or alternative agonist C21 also changes mouse…”
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Notch1 is required for maintenance of the reservoir of adult hippocampal stem cells by Ables, Jessica L, Decarolis, Nathan A, Johnson, Madeleine A, Rivera, Phillip D, Gao, Zhengliang, Cooper, Don C, Radtke, Freddy, Hsieh, Jenny, Eisch, Amelia J

“…Notch1 regulates neural stem cell (NSC) number during development, but its role in adult neurogenesis is unclear. We generated…”
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Ascl1 (Mash1) defines cells with long-term neurogenic potential in subgranular and subventricular zones in adult mouse brain by Kim, Euiseok J, Ables, Jessica L, Dickel, Lauren K, Eisch, Amelia J, Johnson, Jane E

“…Ascl1 (Mash1) is a bHLH transcription factor essential for neural differentiation during embryogenesis but its role in adult neurogenesis is less clear. Here…”
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Optimizing brain performance: Identifying mechanisms of adaptive neurobiological plasticity by Lambert, Kelly, Eisch, Amelia J., Galea, Liisa A.M., Kempermann, Gerd, Merzenich, Michael

“…•Neural processes interact with dynamic environments to generate adaptive functions.•Neural plasticity is differentially influenced by individual and context…”
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Chronic Antidepressant Treatment Increases Neurogenesis in Adult Rat Hippocampus by Malberg, Jessica E, Eisch, Amelia J, Nestler, Eric J, Duman, Ronald S

“…Recent studies suggest that stress-induced atrophy and loss of hippocampal neurons may contribute to the pathophysiology of depression. The aim of this study…”
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The P7C3 class of neuroprotective compounds exerts antidepressant efficacy in mice by increasing hippocampal neurogenesis by Walker, A K, Rivera, P D, Wang, Q, Chuang, J-C, Tran, S, Osborne-Lawrence, S, Estill, S J, Starwalt, R, Huntington, P, Morlock, L, Naidoo, J, Williams, N S, Ready, J M, Eisch, A J, Pieper, A A, Zigman, J M

“…Augmenting hippocampal neurogenesis represents a potential new strategy for treating depression. Here we test this possibility by comparing hippocampal…”
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Stimulation of entorhinal cortex–dentate gyrus circuitry is antidepressive by Yun, Sanghee, Reynolds, Ryan P., Petrof, Iraklis, White, Alicia, Rivera, Phillip D., Segev, Amir, Gibson, Adam D., Suarez, Maiko, DeSalle, Matthew J., Ito, Naoki, Mukherjee, Shibani, Richardson, Devon R., Kang, Catherine E., Ahrens-Nicklas, Rebecca C., Soler, Ivan, Chetkovich, Dane M., Kourrich, Saïd, Coulter, Douglas A., Eisch, Amelia J.

“…Major depressive disorder (MDD) is considered a ‘circuitopathy’, and brain stimulation therapies hold promise for ameliorating MDD symptoms, including…”
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Adult hippocampal neurogenesis is functionally important for stress-induced social avoidance by Lagace, Diane C, Donovan, Michael H, DeCarolis, Nathan A, Farnbauch, Laure A, Malhotra, Shveta, Berton, Olivier, Nestler, Eric J, Krishnan, Vaishnav, Eisch, Amelia J

“…The long-term response to chronic stress is variable, with some individuals developing maladaptive functioning, although other "resilient" individuals do not…”
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Ablation of Fmrp in adult neural stem cells disrupts hippocampus-dependent learning by Guo, Weixiang, Allan, Andrea M, Zong, Ruiting, Zhang, Li, Johnson, Eric B, Schaller, Eric G, Murthy, Adeline C, Goggin, Samantha L, Eisch, Amelia J, Oostra, Ben A, Nelson, David L, Jin, Peng, Zhao, Xinyu

“…Fragile X mental retardation is caused by mutations in the FMRP gene. Now, Xinyu Zhao and her colleagues show that deletion of Fmrp specifically in adult…”
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In vivo contribution of nestin- and GLAST-lineage cells to adult hippocampal neurogenesis by DeCarolis, Nathan A., Mechanic, Maxwell, Petrik, David, Carlton, Adam, Ables, Jessica L., Malhotra, Shveta, Bachoo, Robert, Götz, Magdalena, Lagace, Diane C., Eisch, Amelia J.

“…ABSTRACT Radial glia‐like cells (RGCs) are the hypothesized source of adult hippocampal neurogenesis. However, the current model of hippocampal neurogenesis…”
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Detection and Phenotypic Characterization of Adult Neurogenesis by Kuhn, H Georg, Eisch, Amelia J, Spalding, Kirsty, Peterson, Daniel A

“…Studies of adult neurogenesis have greatly expanded in the last decade, largely as a result of improved tools for detecting and quantifying neurogenesis. In…”
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Neurobiology of Depression by Nestler, Eric J., Barrot, Michel, DiLeone, Ralph J., Eisch, Amelia J., Gold, Stephen J., Monteggia, Lisa M.

“…Current treatments for depression are inadequate for many individuals, and progress in understanding the neurobiology of depression is slow. Several promising…”
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Dynamic Contribution of Nestin-Expressing Stem Cells to Adult Neurogenesis by Lagace, Diane C, Whitman, Mary C, Noonan, Michele A, Ables, Jessica L, DeCarolis, Nathan A, Arguello, Amy A, Donovan, Michael H, Fischer, Stephanie J, Farnbauch, Laure A, Beech, Robert D, DiLeone, Ralph J, Greer, Charles A, Mandyam, Chitra D, Eisch, Amelia J

“…Understanding the fate of adult-generated neurons and the mechanisms that influence them requires consistent labeling and tracking of large numbers of stem…”
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The Interesting Interplay Between Interneurons and Adult Hippocampal Neurogenesis by Masiulis, Irene, Yun, Sanghee, Eisch, Amelia J.

“…Adult neurogenesis is a unique form of plasticity found in the hippocampus, a brain region key to learning and memory formation. While many external stimuli…”
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