Search Results - "Eisch, Amelia"

Depression and Hippocampal Neurogenesis: A Road to Remission? by Eisch, Amelia J., Petrik, David

“…Adult-generated hippocampal neurons are required for mood control and antidepressant efficacy, raising hopes that someday we can harness the power of new…”
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Re-evaluating the link between neuropsychiatric disorders and dysregulated adult neurogenesis by Yun, Sanghee, Reynolds, Ryan P, Masiulis, Irene, Eisch, Amelia J

“…Recent evidence indicates that one of the underlying mechanisms in the pathogenesis of neuropsychiatric disorders is dysregulated dentate gyrus neurogenesis…”
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Aberrant hippocampal neurogenesis contributes to epilepsy and associated cognitive decline by Cho, Kyung-Ok, Lybrand, Zane R., Ito, Naoki, Brulet, Rebecca, Tafacory, Farrah, Zhang, Ling, Good, Levi, Ure, Kerstin, Kernie, Steven G., Birnbaum, Shari G., Scharfman, Helen E., Eisch, Amelia J., Hsieh, Jenny

“…Acute seizures after a severe brain insult can often lead to epilepsy and cognitive impairment. Aberrant hippocampal neurogenesis follows the insult but the…”
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Ascl1 (Mash1) defines cells with long-term neurogenic potential in subgranular and subventricular zones in adult mouse brain by Kim, Euiseok J, Ables, Jessica L, Dickel, Lauren K, Eisch, Amelia J, Johnson, Jane E

“…Ascl1 (Mash1) is a bHLH transcription factor essential for neural differentiation during embryogenesis but its role in adult neurogenesis is less clear. Here…”
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The neurogenesis hypothesis of affective and anxiety disorders: Are we mistaking the scaffolding for the building? by Petrik, David, Lagace, Diane C., Eisch, Amelia J.

“…Hypotheses are scaffoldings erected in front of a building and then dismantled when the building is finished. They are indispensable for the workman; but you…”
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Hippocampal neurogenesis as a target for the treatment of mental illness: A critical evaluation by DeCarolis, Nathan A., Eisch, Amelia J.

“…Over one-quarter of adult Americans are diagnosed with a mental illness like Major Depressive Disorder (MDD), Post-Traumatic Stress Disorder (PTSD),…”
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Epigenetics, hippocampal neurogenesis, and neuropsychiatric disorders: Unraveling the genome to understand the mind by Hsieh, Jenny, Eisch, Amelia J

“…Abstract In mature, differentiated neurons in the central nervous system (CNS), epigenetic mechanisms—including DNA methylation, histone modification, and…”
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Not(ch) just development: Notch signalling in the adult brain by Eisch, Amelia J, Rakic, Pasko, Ables, Jessica L, Breunig, Joshua J

“…Key Points Notch is an evolutionarily conserved, membrane-bound receptor whose ligands are also membrane-bound. As ligand-mediated enzymatic cleavage of Notch…”
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Neurod1 is essential for the survival and maturation of adult-born neurons by Hsieh, Jenny, Gao, Zhengliang, Ure, Kerstin, Ables, Jessica L, Lagace, Diane C, Nave, Klaus-Armin, Goebbels, Sandra, Eisch, Amelia J

“…The transcriptional program that controls adult neurogenesis is unknown. We generated mice with an inducible stem cell-specific deletion of Neurod1, resulting…”
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Does chronic systemic injection of the DREADD agonists clozapine-N-oxide or Compound 21 change behavior relevant to locomotion, exploration, anxiety, and depression in male non-DREADD-expressing mice? by Tran, Fionya H., Spears, Stella L., Ahn, Kyung J., Eisch, Amelia J., Yun, Sanghee

“…•Acute injection of CNO changes behavior of non-DREADD-expressing mice.•It’s not known if chronic CNO or alternative agonist C21 also changes mouse…”
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Notch1 is required for maintenance of the reservoir of adult hippocampal stem cells by Ables, Jessica L, Decarolis, Nathan A, Johnson, Madeleine A, Rivera, Phillip D, Gao, Zhengliang, Cooper, Don C, Radtke, Freddy, Hsieh, Jenny, Eisch, Amelia J

“…Notch1 regulates neural stem cell (NSC) number during development, but its role in adult neurogenesis is unclear. We generated…”
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Optimizing brain performance: Identifying mechanisms of adaptive neurobiological plasticity by Lambert, Kelly, Eisch, Amelia J., Galea, Liisa A.M., Kempermann, Gerd, Merzenich, Michael

“…•Neural processes interact with dynamic environments to generate adaptive functions.•Neural plasticity is differentially influenced by individual and context…”
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B cells migrate into remote brain areas and support neurogenesis and functional recovery after focal stroke in mice by Ortega, Sterling B., Torres, Vanessa O., Latchney, Sarah E., Whoolery, Cody W., Noorbhai, Ibrahim Z., Poinsatte, Katie, Selvaraj, Uma M., Benson, Monica A., Meeuwissen, Anouk J. M., Plautz, Erik J., Kong, Xiangmei, Ramirez, Denise M., Ajay, Apoorva D., Meeks, Julian P., Goldberg, Mark P., Monson, Nancy L., Eisch, Amelia J., Stowe, Ann M.

“…Lymphocytes infiltrate the stroke core and penumbra and often exacerbate cellular injury. B cells, however, are lymphocytes that do not contribute to acute…”
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Female and male rats readily consume and prefer oxycodone to water in a chronic, continuous access, two-bottle oral voluntary paradigm by Zanni, Giulia, DeSalle, Matthew J., Deutsch, Hannah M., Barr, Gordon A., Eisch, Amelia J.

“…The increasing abuse of opioids - such as oxycodone - poses major challenges for health and socioeconomic systems. Human prescription opioid abuse is marked by…”
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Developmental Brain Injury and Social Determinants of Health: Opportunities to Combine Preclinical Models for Mechanistic Insights into Recovery by Guez-Barber, Danielle, Eisch, Amelia J, Cristancho, Ana G

“…Epidemiological studies show that social determinants of health are among the strongest factors associated with developmental outcomes after prenatal and…”
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Stimulation of entorhinal cortex–dentate gyrus circuitry is antidepressive by Yun, Sanghee, Reynolds, Ryan P., Petrof, Iraklis, White, Alicia, Rivera, Phillip D., Segev, Amir, Gibson, Adam D., Suarez, Maiko, DeSalle, Matthew J., Ito, Naoki, Mukherjee, Shibani, Richardson, Devon R., Kang, Catherine E., Ahrens-Nicklas, Rebecca C., Soler, Ivan, Chetkovich, Dane M., Kourrich, Saïd, Coulter, Douglas A., Eisch, Amelia J.

“…Major depressive disorder (MDD) is considered a ‘circuitopathy’, and brain stimulation therapies hold promise for ameliorating MDD symptoms, including…”
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Adult hippocampal neurogenesis is functionally important for stress-induced social avoidance by Lagace, Diane C, Donovan, Michael H, DeCarolis, Nathan A, Farnbauch, Laure A, Malhotra, Shveta, Berton, Olivier, Nestler, Eric J, Krishnan, Vaishnav, Eisch, Amelia J

“…The long-term response to chronic stress is variable, with some individuals developing maladaptive functioning, although other "resilient" individuals do not…”
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Female and male microglia are not different in the dentate gyrus of postnatal day 10 mice by Guez-Barber, Danielle, Colon, Lorianna M., Raphael, Dana, Wragan, Max A., Yun, Sanghee, Eisch, Amelia J.

“…•Sex differences in Iba1+ cells were assessed in the dentate gyrus (DG) of P10 mice.•Iba1+ cells were assessed in DG microglia-rich subregions: Hilus and…”
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Reduction of Adult Hippocampal Neurogenesis Confers Vulnerability in an Animal Model of Cocaine Addiction by Noonan, Michele A, Bulin, Sarah E, Fuller, Dwain C, Eisch, Amelia J

“…Drugs of abuse dynamically regulate adult neurogenesis, which appears important for some types of learning and memory. Interestingly, a major site of adult…”
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Kctd13 deletion reduces synaptic transmission via increased RhoA by Escamilla, Christine Ochoa, Filonova, Irina, Walker, Angela K., Xuan, Zhong X., Holehonnur, Roopashri, Espinosa, Felipe, Liu, Shunan, Thyme, Summer B., López-García, Isabel A., Mendoza, Dorian B., Usui, Noriyoshi, Ellegood, Jacob, Eisch, Amelia J., Konopka, Genevieve, Lerch, Jason P., Schier, Alexander F., Speed, Haley E., Powell, Craig M.

“…Experimental evidence that global Kctd13 reduction leads to increased RhoA levels that reduce synaptic transmission, implicating RhoA as a potential…”
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