Search Results - "Einstein, David"

Hot or Not: Tumor Mutational Burden (TMB) as a Biomarker of Immunotherapy Response in Genitourinary Cancers by Halbert, Brian, Einstein, David J.

“…Pembrolizumab was recently approved for treatment of cancers with high tumor mutational burden (TMB). We conduct a focused literature review of TMB as a…”
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Compassion and Compassionate Use by Einstein, David J

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Toxicity, uptake, and accumulation of nano and bulk cerium oxide particles in Artemia salina by Sugantharaj David, Einstein Mariya David, Madurantakam Royam, Madhav, Rajamani Sekar, Suresh Kumar, Manivannan, Bhuvaneshwari, Jalaja Soman, Swathy, Mukherjee, Amitava, Natarajan, Chandrasekaran

“…Although the toxicological impact of metal oxide nanoparticles has been studied for the last few decades on aquatic organisms, the exact mechanism of action is…”
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Treatment Approaches for Cisplatin-Ineligible Patients with Invasive Bladder Cancer by Einstein, David J., Sonpavde, Guru

“…Opinion statement Cisplatin has been established as an important agent in the neoadjuvant setting prior to radical cystectomy (RC) surgery for muscle-invasive…”
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Targeting the androgen receptor and overcoming resistance in prostate cancer by Einstein, David J, Arai, Seiji, Balk, Steven P

“…PURPOSE OF REVIEWProstate cancer (PCa) is diagnosed in one out of every nine men and is the second leading cause of cancer death among men. Although therapies…”
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MR imaging of the small bowel by Fidler, Jeff L, Guimaraes, Luis, Einstein, David M

“…Cross-sectional imaging techniques are playing an increasing role in the evaluation of suspected small-bowel disorders, and a growing awareness of the risks of…”
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Reply to B. Tombal et al by Einstein, David J., Regan, Meredith M., Stevens, Julia S., McDermott, David F., Madan, Ravi A.

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Metastasis-Free Survival Versus Treatment-Free Survival in Biochemically Recurrent Prostate Cancer: The EMBARK Trial by Einstein, David J, Regan, Meredith M, Stevens, Julia S, McDermott, David F, Madan, Ravi A

“…What is most important to patients with BCR prostate cancer? Metastasis-free versus treatment-free survival…”
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Autocrine Canonical Wnt Signaling Primes Noncanonical Signaling through ROR1 in Metastatic Castration-Resistant Prostate Cancer by Ma, Fen, Arai, Seiji, Wang, Keshan, Calagua, Carla, Yuan, Amanda R, Poluben, Larysa, Gu, Zhongkai, Russo, Joshua W, Einstein, David J, Ye, Huihui, He, Meng Xiao, Liu, Yu, Van Allen, Eliezer, Sowalsky, Adam G, Bhasin, Manoj K, Yuan, Xin, Balk, Steven P

“…Wnt signaling driven by genomic alterations in genes including APC and CTNNB, which encodes β-catenin, have been implicated in prostate cancer development and…”
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Biochemically recurrent prostate cancer in the era of EMBARK and PSMA PET imaging: everything has changed, except the patients by Einstein, David J, Aragon-Ching, Jeanny B, Karzai, Fatima, Madan, Ravi A

“…Patients with biochemically recurrent prostate cancer (BCR) after unsuccessful curative therapies frequently have an indolent and asymptomatic disease course…”
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Comparative Genomics Reveals Distinct Immune-oncologic Pathways in African American Men with Prostate Cancer by Awasthi, Shivanshu, Berglund, Anders, Abraham-Miranda, Julieta, Rounbehler, Robert J, Kensler, Kevin, Serna, Amparo, Vidal, Adriana, You, Sungyong, Freeman, Michael R, Davicioni, Elai, Liu, Yang, Karnes, R Jeffrey, Klein, Eric A, Den, Robert B, Trock, Bruce J, Campbell, Joshua D, Einstein, David J, Gupta, Raavi, Balk, Steven, Lal, Priti, Park, Jong Y, Cleveland, John L, Rebbeck, Timothy R, Freedland, Stephen J, Yamoah, Kosj

“…The role of immune-oncologic mechanisms of racial disparities in prostate cancer remains understudied. Limited research exists to evaluate the molecular…”
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Tivozanib in relapsed or refractory advanced renal cell carcinoma: a focus on US approval by Viray, Hollis, McDermott, David F, Einstein, David J

“…Tivozanib is a selective vascular endothelial growth factor receptor (VEGFR)-inhibitor designed to, more specifically, bind to the VEGF receptor with fewer…”
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Prevalence and Morbidity of Local Treatment-Related Side Effects in Metastatic Prostate Cancer Patients by Sentana-Lledo, Daniel, Dodge, Laura E., Chang, Peter, Einstein, David J.

“…•Metastatic recurrent prostate cancer patients suffer from local treatment toxicity.•Persistent urinary and bowel symptoms partly accounted for the higher…”
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Immune mechanisms behind prostate cancer in men of African ancestry: A review by Sentana‐Lledo, Daniel, Sartor, Oliver, Balk, Steven P., Einstein, David J.

“…Background Men of African ancestry (AA) with prostate cancer suffer from worse outcomes. However, a recent analysis of patients treated with the dendritic cell…”
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Results of a Randomized Phase II Trial of Intense Androgen Deprivation Therapy prior to Radical Prostatectomy in Men with High-Risk Localized Prostate Cancer by McKay, Rana R, Xie, Wanling, Ye, Huihui, Fennessy, Fiona M, Zhang, Zhenwei, Lis, Rosina, Calagua, Carla, Rathkopf, Dana, Laudone, Vincent P, Bubley, Glenn J, Einstein, David J, Chang, Peter K, Wagner, Andrew A, Parsons, J Kellogg, Preston, Mark A, Kilbridge, Kerry, Chang, Steven L, Choudhury, Atish D, Pomerantz, Mark M, Trinh, Quoc-Dien, Kibel, Adam S, Taplin, Mary-Ellen

“…This multicenter randomized phase 2 trial investigates the impact of intense androgen deprivation on radical prostatectomy pathologic response and radiographic…”
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Rational Alteration of Pharmacokinetics of Chiral Fluorinated and Deuterated Derivatives of Emixustat for Retinal Therapy by Blum, Eliav, Zhang, Jianye, Zaluski, Jordan, Einstein, David E, Korshin, Edward E, Kubas, Adam, Gruzman, Arie, Tochtrop, Gregory P, Kiser, Philip D, Palczewski, Krzysztof

“…Recycling of all-trans-retinal to 11-cis-retinal through the visual cycle is a fundamental metabolic pathway in the eye. A potent retinoid isomerase (RPE65)…”
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A Subset of Localized Prostate Cancer Displays an Immunogenic Phenotype Associated with Losses of Key Tumor Suppressor Genes by Calagua, Carla, Ficial, Miriam, Jansen, Caroline S, Hirz, Taghreed, Del Balzo, Luke, Wilkinson, Scott, Lake, Ross, Ku, Anson T, Voznesensky, Olga, Sykes, David B, Saylor, Philip J, Ye, Huihui, Signoretti, Sabina, Kissick, Haydn, Sowalsky, Adam G, Balk, Steven P, Einstein, David J

“…A subset of primary prostate cancer expresses programmed death-ligand 1 (PD-L1), but whether they have a unique tumor immune microenvironment or genomic…”
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Dominant role for pigment epithelial CRALBP in supplying visual chromophore to photoreceptors by Bassetto, Marco, Kolesnikov, Alexander V., Lewandowski, Dominik, Kiser, Jianying Z., Halabi, Maximilian, Einstein, David E., Choi, Elliot H., Palczewski, Krzysztof, Kefalov, Vladimir J., Kiser, Philip D.

“…Cellular retinaldehyde-binding protein (CRALBP) supports production of 11-cis-retinaldehyde and its delivery to photoreceptors. It is found in the retinal…”
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Dying for Advice: Code Status Discussions between Resident Physicians and Patients with Advanced Cancer--A National Survey by Einstein, David J, Einstein, Katherine Levine, Mathew, Paul

“…Patients with treatment-resistant advanced cancer rarely benefit from cardiopulmonary resuscitation (CPR) but infrequently discuss end-of-life care with…”
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AKT Inhibition Sensitizes to Polo-Like Kinase 1 Inhibitor Onvansertib in Prostate Cancer by Nouri, Mannan, Varkaris, Andreas, Ridinger, Maya, Dalrymple, Susan L, Dennehy, Christopher M, Isaacs, John T, Einstein, David J, Brennen, W N, Balk, Steven P

“…Polo-like kinase 1 (PLK1) inhibitors have had limited antitumor efficacy as single agents, and focus of current efforts is on combination therapies. We…”
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