Search Results - "Einhorn, T A"

Fragility fractures of the hip and femur: incidence and patient characteristics by Nieves, J. W, Bilezikian, J. P, Lane, J. M, Einhorn, T. A, Wang, Y, Steinbuch, M, Cosman, F

“…Summary Using national discharge and medical claims data, we studied the epidemiology of femoral fractures from 1996 to 2006. The annual hip fracture incidence…”
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Molecular Mechanisms Controlling Bone Formation during Fracture Healing and Distraction Osteogenesis by AI-Aql, Z.S., Alagl, A.S., Graves, D.T., Gerstenfeld, L.C., Einhorn, T.A.

“…Fracture healing and distraction osteogenesis have important applications in orthopedic, maxillofacial, and periodontal treatment. In this review, the cellular…”
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Impaired Fracture Healing in the Absence of TNF‐α Signaling: The Role of TNF‐α in Endochondral Cartilage Resorption by Gerstenfeld, LC, Cho, T‐J, Kon, T, Aizawa, T, Tsay, A, Fitch, J, Barnes, GL, Graves, DT, Einhorn, TA

“…TNF‐α is a major inflammatory factor that is induced in response to injury, and it contributes to the normal regulatory processes of bone resorption. The role…”
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The cell and molecular biology of fracture healing by Einhorn, T A

“…Fracture healing is a complex physiologic process that involves the coordinated participation of several cell types. By using a reproducible model of…”
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Interaction of bone morphogenetic proteins with cells of the osteoclast lineage : review of the existing evidence by GIANNOUDIS, P. V, KANAKARIS, N. K, EINHORN, T. A

“…The present review evaluates the existing scientific proofs of this supplementary role of the BMPs and summarises its clinical implications. Bone regeneration…”
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BMP2 is essential for post natal osteogenesis but not for recruitment of osteogenic stem cells by Bais, M.V, Wigner, N, Young, M, Toholka, R, Graves, D.T, Morgan, E.F, Gerstenfeld, L.C, Einhorn, T.A

“…Abstract The effects of BMP2 on bone marrow stromal cell differentiation and bone formation after bone marrow ablation were determined using C57 BL/6J (B6)…”
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Delayed administration of adenoviral BMP-2 vector improves the formation of bone in osseous defects by BETZ, O. B, BETZ, V. M, NAZARIAN, A, EGERMANN, M, GERSTENFELD, L. C, EINHORN, T. A, VRAHAS, M. S, BOUXSEIN, M. L, EVANS, C. H

“…The direct, local, administration of adenovirus carrying human BMP-2 cDNA (Ad.BMP-2) heals critical-sized femoral bone defects in rabbit and rat models…”
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Enhancement of fracture-healing by Einhorn, T A

“…In this article, I will review some of the better described and more extensively tested methods that have been used to stimulate fracture-healing. I will also…”
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Tumor necrosis factor alpha (TNF-α) coordinately regulates the expression of specific matrix metalloproteinases (MMPS) and angiogenic factors during fracture healing by Lehmann, W., Edgar, C.M., Wang, K., Cho, T-J., Barnes, G.L., Kakar, S., Graves, D.T., Rueger, J.M., Gerstenfeld, L.C., Einhorn, T.A.

“…Recent studies from our laboratory demonstrate that TNF-α signaling contributes to the regulation of chondrocyte apoptosis and a lack of TNF-α signaling leads…”
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The role of angiogenesis in a murine tibial model of distraction osteogenesis by Carvalho, R.S, Einhorn, T.A, Lehmann, W, Edgar, C, Al-Yamani, A, Apazidis, A, Pacicca, D, Clemens, T.L, Gerstenfeld, L.C

“…Distraction osteogenesis (DO) is one of the most dramatic in vivo applications of mechanical stimulation as a means of inducing bone regeneration. A simple and…”
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Use of genetically modified muscle and fat grafts to repair defects in bone and cartilage by Evans, C H, Liu, F-J, Glatt, V, Hoyland, J A, Kirker-Head, C, Walsh, A, Betz, O, Wells, J W, Betz, V, Porter, R M, Saad, F A, Gerstenfeld, L C, Einhorn, T A, Harris, M B, Vrahas, M S

“…We report a novel technology for the rapid healing of large osseous and chondral defects, based upon the genetic modification of autologous skeletal muscle and…”
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Osteoarthritis and stem cell therapy in humans: a systematic review by Jevotovsky, D.S., Alfonso, A.R., Einhorn, T.A., Chiu, E.S.

“…Osteoarthritis (OA) is a leading cause of disability in the world. Mesenchymal stem cells (MSCs) have been studied to treat OA. This review was performed to…”
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Fractures Attributable to Osteoporosis: Report from the National Osteoporosis Foundation by Melton, L. J., Thamer, M., Ray, N. F., Chan, J. K., Chesnut, C. H., Einhorn, T. A., Johnston, C. C., Raisz, L. G., Silverman, S. L., Siris, E. S.

“…To assess the cost‐effectiveness of interventions to prevent osteoporosis, it is necessary to estimate total health care expenditures for the treatment of…”
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Induction of apoptosis in chondrocytes by tumor necrosis factor-alpha by Aizawa, T, Kon, T, Einhorn, T.A, Gerstenfeld, L.C

“…Tumor necrosis factor alpha (TNF-α) induces apoptosis in a number of cell types and plays an essential role in bone remodeling, both stimulating the…”
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Growth Factor Regulation of Fracture Repair by Barnes, George L., Kostenuik, Paul J., Gerstenfeld, Louis C., Einhorn, Thomas A.

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Expression of angiogenic factors during distraction osteogenesis by Pacicca, D.M, Patel, N, Lee, C, Salisbury, K, Lehmann, W, Carvalho, R, Gerstenfeld, L.C, Einhorn, T.A

“…Distraction osteogenesis is a unique and effective way to treat limb length inequality resulting from congenital and posttraumatic skeletal defects. However,…”
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Expression and role of interleukin-6 in distraction osteogenesis by Cho, T-J, Kim, J A, Chung, C Y, Yoo, W J, Gerstenfeld, L C, Einhorn, T A, Choi, I H

“…Distraction osteogenesis is a special form of bone healing in which well-controlled distraction stresses and consequent tensile strains within callus tissue…”
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Differential inhibition of fracture healing by non-selective and cyclooxygenase-2 selective non-steroidal anti-inflammatory drugs by Gerstenfeld, Louis C, Thiede, Mark, Seibert, Karen, Mielke, Cindy, Phippard, Deborah, Svagr, Bohus, Cullinane, Dennis, Einhorn, Thomas A

“…Non-steroidal anti-inflammatory drugs (NSAIDs) specifically inhibit cyclooxygenase (COX) activity and are widely used as anti-arthritics, post-surgical…”
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Clinically applied models of bone regeneration in tissue engineering research by Einhorn, T A

“…The development of new strategies for the engineering of bone regeneration requires appropriate model systems. Selection of the best model for testing a new…”
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Recommendations for the conduct of economic evaluations in osteoporosis: outcomes of an experts’ consensus meeting organized by the European Society for Clinical and Economic Aspects of Osteoporosis, Osteoarthritis and Musculoskeletal Diseases (ESCEO) and the US branch of the International Osteoporosis Foundation by Hiligsmann, M., Reginster, J.-Y., Tosteson, A.N.A., Bukata, S.V., Saag, K.G., Gold, D.T., Halbout, P., Jiwa, F., Lewiecki, E.M., Pinto, D., Adachi, J.D., Al-Daghri, N., Bruyère, O., Chandran, M., Cooper, C., Harvey, N.C., Einhorn, T.A., Kanis, J.A., Kendler, D.L., Messina, O.D., Rizzoli, R., Si, L., Silverman, S.

“…Summary Economic evaluations are increasingly used to assess the value of health interventions, but variable quality and heterogeneity limit the use of these…”
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