Search Results - "Einck, Leo"

In Vitro Interactions between New Antitubercular Drug Candidates SQ109 and TMC207 by REDDY, Venkata M, EINCK, Leo, ANDRIES, K, NACY, Carol A

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Identification of a new antitubercular drug candidate, SQ109, from a combinatorial library of 1,2-ethylenediamines by Protopopova, Marina, Hanrahan, Colleen, Nikonenko, Boris, Samala, Rowena, Chen, Ping, Gearhart, Jackie, Einck, Leo, Nacy, Carol A.

“…Objectives: The aim of this study was to identify a candidate drug for clinical development from a previously synthesized combinatorial library based on the…”
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Drug Therapy of Experimental Tuberculosis (TB): Improved Outcome by Combining SQ109, a New Diamine Antibiotic, with Existing TB Drugs by NIKONENKO, Boris V, PROTOPOPOVA, Marina, SAMALA, Rowena, EINCK, Leo, NACY, Carol A

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Therapeutic Efficacy of SQ641-NE against Mycobacterium tuberculosis by NIKONENKO, Boris, REDDY, Venkata M, BOGATCHEVA, Elena, PROTOPOPOVA, Marina, EINCK, Leo, NACY, Carol A

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In Vitro Antimycobacterial Activities of Capuramycin Analogues by REDDY, Venkata M, EINCK, Leo, NACY, Carol A

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In vitro characterization of the anti-bacterial activity of SQ109 against Helicobacter pylori by Makobongo, Morris O, Einck, Leo, Peek, Jr, Richard M, Merrell, D Scott

“…The most evident challenge to treatment of Helicobacter pylori, a bacterium responsible for gastritis, peptic ulcers and gastric cancer, is the increasing rate…”
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Activity of SQ641, a Capuramycin Analog, in a Murine Model of Tuberculosis by NIKONENKO, Boris V, REDDY, Venkata M, PROTOPOPOVA, Marina, BOGATCHEVA, Elena, EINCK, Leo, NACY, Carol A

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Chemical modification of capuramycins to enhance antibacterial activity by BOGATCHEVA, Elena, DUBUISSON, Tia, PROTOPOPOVA, Marina, EINCK, Leo, NACY, Carol A, REDDY, Venkata M

“…To extend capuramycin spectrum of activity beyond mycobacteria and improve intracellular drug activity. Three capuramycin analogues (SQ997, SQ922 and SQ641)…”
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Rapid, Simple In Vivo Screen for New Drugs Active against Mycobacterium tuberculosis by Nikonenko, Boris V, Samala, Rowena, Einck, Leo, Nacy, Carol A

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Generation of a novel nucleic acid-based reporter system to detect phenotypic susceptibility to antibiotics in Mycobacterium tuberculosis by Mulvey, Matthew C, Sacksteder, Katherine A, Einck, Leo, Nacy, Carol A

“…We designed, constructed, and evaluated a prototype novel reporter system comprised of two functional cassettes: (i) the SP6 RNA polymerase gene under…”
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In search of new cures for tuberculosis by Protopopova, Marina, Bogatcheva, Elena, Nikonenko, Boris, Hundert, Sam, Einck, Leo, Nacy, Carol A

“…The last 10 years have seen resurgent industry activity in discovery and development of new drugs for the treatment of tuberculosis (TB), a growing widespread…”
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Synergistic interactions of SQ109, a new ethylene diamine, with front-line antitubercular drugs in vitro by Chen, Ping, Gearhart, Jackie, Protopopova, Marina, Einck, Leo, Nacy, Carol A.

“…Objectives: The purpose of this study was to determine interactions of SQ109, a new asymmetric diamine tuberculosis (TB) drug candidate, with existing…”
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Identification of SQ609 as a lead compound from a library of dipiperidines by Bogatcheva, Elena, Hanrahan, Colleen, Nikonenko, Boris, de los Santos, Gladys, Reddy, Venkata, Chen, Ping, Barbosa, Francis, Einck, Leo, Nacy, Carol, Protopopova, Marina

“…We recently reported that compounds created around a dipiperidine scaffold demonstrated activity against Mycobacterium tuberculosis (Mtb) (Bogatcheva, E.;…”
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Optimization of a nucleic acid-based reporter system to detect Mycobacterium tuberculosis antibiotic sensitivity by Mulvey, Matthew C, Lemmon, Margaret, Rotter, Stephanie, Lees, Jonathan, Einck, Leo, Nacy, Carol A

“…We previously reported the development of a prototype antibiotic sensitivity assay to detect drug-resistant Mycobacterium tuberculosis using infection by…”
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Agility in adversity: Vaccines on Demand by De Groot, Anne S, Moise, Leonard, Olive, David, Einck, Leo, Martin, William

“…Is the US ready for a biological attack using Ebola virus or Anthrax? Will vaccine developers be able to produce a Zika virus vaccine, before the epidemic…”
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Identification of New Diamine Scaffolds with Activity against Mycobacterium tuberculosis by Bogatcheva, Elena, Hanrahan, Colleen, Nikonenko, Boris, Samala, Rowena, Chen, Ping, Gearhart, Jacqueline, Barbosa, Francis, Einck, Leo, Nacy, Carol A, Protopopova, Marina

“…A diverse 5000-compound library was synthesized from commercially available diamines and screened for activity against Mycobacterium tuberculosis in vitro,…”
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Antitubercular Nanocarrier Combination Therapy: Formulation Strategies and in Vitro Efficacy for Rifampicin and SQ641 by D’Addio, Suzanne M, Reddy, Venkata M, Liu, Ying, Sinko, Patrick J, Einck, Leo, Prud’homme, Robert K

“…Tuberculosis (TB) remains a major global health concern, and new therapies are needed to overcome the problems associated with dosing frequency, patient…”
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Discovery of dipiperidines as new antitubercular agents by Bogatcheva, Elena, Hanrahan, Colleen, Chen, Ping, Gearhart, Jacqueline, Sacksteder, Katherine, Einck, Leo, Nacy, Carol, Protopopova, Marina

“…As part of our ongoing research effort to develop new therapeutics for treatment of tuberculosis (TB), we synthesized a combinatorial library of 10,358…”
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SQ109 and PNU-100480 interact to kill Mycobacterium tuberculosis in vitro by REDDY, Venkata M, DUBUISSON, Tia, EINCK, Leo, WALLIS, Robert S, JAKUBIEC, Wesley, LADUKTO, Lynn, CAMPBELL, Sheldon, NACY, Carol A

“…To investigate in vitro interaction between two compounds, SQ109 and PNU-100480, currently in development for the treatment of Mycobacterium tuberculosis…”
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Treatment of Clostridium difficile infection using SQ641, a capuramycin analogue, increases post-treatment survival and improves clinical measures of disease in a murine model by Moore, 2nd, John H, van Opstal, Edward, Kolling, Glynis L, Shin, Jae Hyun, Bogatcheva, Elena, Nikonenko, Boris, Einck, Leo, Phipps, Andrew J, Guerrant, Richard L, Protopopova, Marina, Warren, Cirle Alcantara

“…Clostridium difficile infection (CDI) is a primary cause of antibiotic-associated diarrhoeal illness. Current therapies are insufficient as relapse rates…”
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