Search Results - "Eimerbrink, M.J."

Imatinib methanesulfonate reduces hyperphosphorylation of tau following repeated peripheral exposure to lipopolysaccharide by Gardner, L.E, White, J.D, Eimerbrink, M.J, Boehm, G.W, Chumley, M.J

“…Highlights • 7 i.p. injections of LPS leads to hippocampal tau phosphorylation. • i.p. injections of LPS leads to increased hippocampal tau expression. •…”
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40. Peripheral administration of d -cycloserine, but not norepinephrine, restores appropriate cognitive function following systemic bacterial endotoxin exposure by Kranjac, D, Koster, K.M, Weintraub, M.S, Eimerbrink, M.J, Womble, B.M, Cooper, B.G, Chumley, M.J, Boehm, G.W

“…Evidence indicates that the ionotropic NMDA and AMPA glutamate neurotransmitter receptors are critically involved in hippocampus-dependent learning and memory…”
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23. Imatinib methanesulfonate reduces hippocampal amyloid-beta and restores cognitive function following repeated endotoxin exposure by Weintraub, M.K, Bisson, C.M, Nouri, J.N, Vinson, B.T, Kranjac, D, Eimerbrink, M.J, Boehm, G.W, Chumley, M.J

“…Alzheimer’s disease (AD) is characterized, in part, by atrophy of the adult brain and increased presence of extracellular amyloid-beta plaques. Previous…”
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Effects of social isolation on LPS-induced hippocampal amyloid-beta expression and cognitive dysfunction in C57BL6/J mice by Peterman, J.L., Eimerbrink, M.J., White, J.D., Boehm, G.W., Chumley, M.J.

“…The connection between inflammation and various disease states is strongly affirmed in the existing literature, along with the connection between stress and…”
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Prolonged isolation stress accelerates the onset of Alzheimer’s disease-related pathology in 5xFAD mice despite running wheels and environmental enrichment by Peterman, J.L., White, J.D., Calcagno, A., Hagen, C., Quiring, M., Paulhus, K., Gurney, T., Eimerbrink, M.J., Curtis, M., Boehm, G.W., Chumley, M.J.

“…•Two and three months of social isolation lead to cognitive deficits in a CFC paradigm in 5xFAD+ and wild-type animals.•Two and three months of social…”
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Prior exposure to repeated peripheral LPS injections prevents further accumulation of hippocampal beta-amyloid by White, J.D., Peterman, J.L., Hardy, A., Eimerbrink, M.J., Paulhus, K.C., Thompson, M.A., Chumley, M.J., Boehm, G.W.

“…Alzheimer’s disease (AD) is characterized by the accumulation of beta-amyloid plaques and neurofibrillary tangles. Our laboratory has previously demonstrated…”
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The α5-GABAAR inverse agonist MRK-016 upregulates hippocampal BDNF expression and prevents cognitive deficits in LPS-treated mice, despite elevations in hippocampal Aβ by Eimerbrink, M.J., Pendry, R.J., Hodges, S.L., Wiles, J.D., Peterman, J.L., White, J.D., Hayes, H.B., Chumley, M.J., Boehm, G.W.

“…•Repeated peripheral LPS administration increases expression of central Aβ.•Administration of MRK-016 post-training rescues memory consolidation following LPS…”
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Hippocampal Aβ expression, but not phosphorylated tau, predicts cognitive deficits following repeated peripheral poly I:C administration by White, J.D., Eimerbrink, M.J., Hayes, H.B., Hardy, A., Van Enkevort, E.A., Peterman, J.L., Chumley, M.J., Boehm, G.W.

“…•7, 14, and 21 days of poly I:C administration increase hippocampal Aβ.•14, but not 7 or 21, days of poly I:C administration increases tau phosphorylation.•14…”
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Administration of the inverse benzodiazepine agonist MRK-016 rescues acquisition and memory consolidation following peripheral administration of bacterial endotoxin by Eimerbrink, M.J., White, J.D., Pendry, R.J., Hodges, S.L., Sadler, L.N., Wiles, J.D., Weintraub, M.K., Chumley, M.J., Boehm, G.W.

“…•MRK-016 rescued memory acquisition following peripheral LPS administration.•MRK-016 rescued memory consolidation following peripheral LPS…”
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Pre-treatment of C57BL6/J mice with the TLR4 agonist monophosphoryl lipid A prevents LPS-induced sickness behaviors and elevations in dorsal hippocampus interleukin-1β, independent of interleukin-4 expression by Eimerbrink, M.J., Kranjac, D., St. Laurent, C., White, J.D., Weintraub, M.K., Pendry, R.J., Madigan, R., Hodges, S.L., Sadler, L.N., Chumley, M.J., Boehm, G.W.

“…•MPLA administration can trigger expression of sickness behaviors in C57BL/6J mice.•Treatment with MPLA for two consecutive days prior to LPS administration is…”
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