The anti-Alzheimer compounds from tempeh oil in LPS-induced neuronal Schwann cells

The anti-Alzheimer compounds from tempeh oil in LPS-induced neuronal Schwann cells

Tempeh is a traditional fermented Indonesian food from white soybean. Tempe has better nutritional value than non-fermented white soybean. The aim of this study was to extract tempeh oil and analyze the inhibitory potency of Alzheimer-related gene expression in LPS-induced neuronal Schwann cells. Te...

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Bibliographic Details
Published in:Journal of Ethnic Foods Vol. 9; no. 1; pp. 1 - 11
Main Authors: Eileen C. Limanjaya, Dionysius Subali, Yanti Yanti
Format: Journal Article
Language:English
Published: Amsterdam BioMed Central 01-01-2022
BMC
Subjects:
Alzheimer's disease
Anticholinesterase
Antioxidant
Antioxidants
Chromatography
Chronic illnesses
Cultural heritage
Cyclin-dependent kinases
Dementia
Enzymes
Fatty acids
Fermentation
Gene expression
Kinases
Omega-3
Petroleum
Proteins
Reagents
Soy products
Soybeans
Tempeh oil
Asia
Indonesia
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Summary:Tempeh is a traditional fermented Indonesian food from white soybean. Tempe has better nutritional value than non-fermented white soybean. The aim of this study was to extract tempeh oil and analyze the inhibitory potency of Alzheimer-related gene expression in LPS-induced neuronal Schwann cells. Tempeh oil was extracted with Bligh Dyer method and was analyzed with PUFA identification, anticholinesterase activity, antioxidant activity, and quantitative PCR. Tempeh oil had a total yield of 7.14%, and PUFA identification found 8.37% omega-3. The anti-acetylcholinesterase activity showed that tempeh oil 25 µg/mL had the highest activity and 500 µg/mL in anti-butyrylcholinesterase activity. The quantitative PCR showed that tempeh oil had downregulated the gene expression of PSEN1, Gsk3b, cdk5, and TNF. From this study, tempeh oil may have the potential to lower the risk of Alzheimer’s disease by regulating certain gene traits.
ISSN:2352-6181
2352-619X
2352-6181
DOI:10.1186/s42779-022-00163-2