Search Results - "Eiger, Dylan Scott"

Location bias contributes to functionally selective responses of biased CXCR3 agonists by Eiger, Dylan Scott, Boldizsar, Noelia, Honeycutt, Christopher Cole, Gardner, Julia, Kirchner, Stephen, Hicks, Chloe, Choi, Issac, Pham, Uyen, Zheng, Kevin, Warman, Anmol, Smith, Jeffrey S., Zhang, Jennifer Y., Rajagopal, Sudarshan

“…Some G protein-coupled receptor (GPCR) ligands act as “biased agonists” that preferentially activate specific signaling transducers over others. Although GPCRs…”
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GPCR systems pharmacology: a different perspective on the development of biased therapeutics by Eiger, Dylan Scott, Pham, Uyen, Gardner, Julia, Hicks, Chloe, Rajagopal, Sudarshan

“…G protein-coupled receptors (GPCRs) are the largest family of transmembrane receptors and are the target of approximately one-third of all Food and Drug…”
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Location bias: A “Hidden Variable” in GPCR pharmacology by Eiger, Dylan Scott, Hicks, Chloe, Gardner, Julia, Pham, Uyen, Rajagopal, Sudarshan

“…Abstract G protein‐coupled receptors (GPCRs) are the largest family of transmembrane receptors and primarily signal through two main effector proteins: G…”
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Biased agonism at chemokine receptors by Eiger, Dylan Scott, Boldizsar, Noelia, Honeycutt, Christopher Cole, Gardner, Julia, Rajagopal, Sudarshan

“…In the human chemokine system, interactions between the approximately 50 known endogenous chemokine ligands and 20 known chemokine receptors (CKRs) regulate a…”
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Biased Agonism at CXCR3 Drives Differential Phosphoproteomic and Transcriptomic Profiles and Cellular Outputs by Eiger, Dylan Scott, Smith, Jeffrey, Tsai, Chia-Feng, Jacobs, Jon, Shi, Tujin, Rajagopal, Sudarshan

“…Abstract only Objective To demonstrate that the endogenous agonists of the chemokine receptor CXCR3 differentially impact the phosphoproteome and transcriptome…”
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