Search Results - "Eide, Peter W."

CMScaller: an R package for consensus molecular subtyping of colorectal cancer pre-clinical models by Eide, Peter W., Bruun, Jarle, Lothe, Ragnhild A., Sveen, Anita

“…Colorectal cancers (CRCs) can be divided into four gene expression-based biologically distinct consensus molecular subtypes (CMS). This classification provides…”
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Multi-omics of 34 colorectal cancer cell lines - a resource for biomedical studies by Berg, Kaja C G, Eide, Peter W, Eilertsen, Ina A, Johannessen, Bjarne, Bruun, Jarle, Danielsen, Stine A, Bjørnslett, Merete, Meza-Zepeda, Leonardo A, Eknæs, Mette, Lind, Guro E, Myklebost, Ola, Skotheim, Rolf I, Sveen, Anita, Lothe, Ragnhild A

“…Colorectal cancer (CRC) cell lines are widely used pre-clinical model systems. Comprehensive insights into their molecular characteristics may improve model…”
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Colorectal Cancer Consensus Molecular Subtypes Translated to Preclinical Models Uncover Potentially Targetable Cancer Cell Dependencies by Sveen, Anita, Bruun, Jarle, Eide, Peter W, Eilertsen, Ina A, Ramirez, Lorena, Murumägi, Astrid, Arjama, Mariliina, Danielsen, Stine A, Kryeziu, Kushtrim, Elez, Elena, Tabernero, Josep, Guinney, Justin, Palmer, Hector G, Nesbakken, Arild, Kallioniemi, Olli, Dienstmann, Rodrigo, Lothe, Ragnhild A

“…Response to standard oncologic treatment is limited in colorectal cancer. The gene expression-based consensus molecular subtypes (CMS) provide a new paradigm…”
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Patient-Derived Organoids from Multiple Colorectal Cancer Liver Metastases Reveal Moderate Intra-patient Pharmacotranscriptomic Heterogeneity by Bruun, Jarle, Kryeziu, Kushtrim, Eide, Peter W, Moosavi, Seyed H, Eilertsen, Ina A, Langerud, Jonas, Røsok, Bård, Totland, Max Z, Brunsell, Tuva H, Pellinen, Teijo, Saarela, Jani, Bergsland, Christian H, Palmer, Hector G, Brudvik, Kristoffer W, Guren, Tormod, Dienstmann, Rodrigo, Guren, Marianne G, Nesbakken, Arild, Bjørnbeth, Bjørn Atle, Sveen, Anita, Lothe, Ragnhild A

“…Molecular tumor heterogeneity may have important implications for the efficacy of targeted therapies in metastatic cancers. Inter-metastatic heterogeneity of…”
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Prognostic, predictive, and pharmacogenomic assessments of CDX2 refine stratification of colorectal cancer by Bruun, Jarle, Sveen, Anita, Barros, Rita, Eide, Peter W., Eilertsen, Ina, Kolberg, Matthias, Pellinen, Teijo, David, Leonor, Svindland, Aud, Kallioniemi, Olli, Guren, Marianne G., Nesbakken, Arild, Almeida, Raquel, Lothe, Ragnhild A.

“…We aimed to refine the value of CDX2 as an independent prognostic and predictive biomarker in colorectal cancer (CRC) according to disease stage and…”
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Increased sensitivity to SMAC mimetic LCL161 identified by longitudinal ex vivo pharmacogenomics of recurrent, KRAS mutated rectal cancer liver metastases by Kryeziu, Kushtrim, Moosavi, Seyed H, Bergsland, Christian H, Guren, Marianne G, Eide, Peter W, Totland, Max Z, Lassen, Kristoffer, Abildgaard, Andreas, Nesbakken, Arild, Sveen, Anita, Lothe, Ragnhild A

“…Abstract Tumor heterogeneity is a primary cause of treatment failure. However, changes in drug sensitivity over time are not well mapped in cancer…”
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De novo transcriptomic subtyping of colorectal cancer liver metastases in the context of tumor heterogeneity by Moosavi, Seyed H, Eide, Peter W, Eilertsen, Ina A, Brunsell, Tuva H, Berg, Kaja C G, Røsok, Bård I, Brudvik, Kristoffer W, Bjørnbeth, Bjørn A, Guren, Marianne G, Nesbakken, Arild, Lothe, Ragnhild A, Sveen, Anita

“…Gene expression-based subtyping has the potential to form a new paradigm for stratified treatment of colorectal cancer. However, current frameworks are based…”
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NEDD4 is overexpressed in colorectal cancer and promotes colonic cell growth independently of the PI3K/PTEN/AKT pathway by Eide, Peter W., Cekaite, Lina, Danielsen, Stine A., Eilertsen, Ina A., Kjenseth, Ane, Fykerud, Tone A., Ågesen, Trude H., Bruun, Jarle, Rivedal, Edgar, Lothe, Ragnhild A., Leithe, Edward

“…Ubiquitination controls multiple cellular processes relevant to cancer pathogenesis. Using Gene Set Enrichment Analysis of an mRNA transcriptome dataset, we…”
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Metastatic heterogeneity of the consensus molecular subtypes of colorectal cancer by Eide, Peter W., Moosavi, Seyed H., Eilertsen, Ina A., Brunsell, Tuva H., Langerud, Jonas, Berg, Kaja C. G., Røsok, Bård I., Bjørnbeth, Bjørn A., Nesbakken, Arild, Lothe, Ragnhild A., Sveen, Anita

“…Gene expression-based subtypes of colorectal cancer have clinical relevance, but the representativeness of primary tumors and the consensus molecular subtypes…”
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E‐cadherin is a robust prognostic biomarker in colorectal cancer and low expression is associated with sensitivity to inhibitors of topoisomerase, aurora, and HSP90 in preclinical models by Bruun, Jarle, Eide, Peter W., Bergsland, Christian Holst, Bruck, Oscar, Svindland, Aud, Arjama, Mariliina, Välimäki, Katja, Bjørnslett, Merete, Guren, Marianne G., Kallioniemi, Olli, Nesbakken, Arild, Lothe, Ragnhild A., Pellinen, Teijo

“…Cell–cell and cell–matrix adhesion proteins that have been implicated in colorectal epithelial integrity and epithelial‐to‐mesenchymal transition could be…”
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Molecular correlates of sensitivity to PARP inhibition beyond homologous recombination deficiency in pre-clinical models of colorectal cancer point to wild-type TP53 activity by Smeby, Jørgen, Kryeziu, Kushtrim, Berg, Kaja C.G., Eilertsen, Ina A., Eide, Peter W., Johannessen, Bjarne, Guren, Marianne G., Nesbakken, Arild, Bruun, Jarle, Lothe, Ragnhild A., Sveen, Anita

“…PARP inhibitors are active in various tumour types beyond BRCA-mutant cancers, but their activity and molecular correlates in colorectal cancer (CRC) are not…”
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The expressed mutational landscape of microsatellite stable colorectal cancers by Sveen, Anita, Johannessen, Bjarne, Eilertsen, Ina A, Røsok, Bård I, Gulla, Marie, Eide, Peter W, Bruun, Jarle, Kryeziu, Kushtrim, Meza-Zepeda, Leonardo A, Myklebost, Ola, Bjørnbeth, Bjørn A, Skotheim, Rolf I, Nesbakken, Arild, Lothe, Ragnhild A

“…Colorectal cancer is the 2nd leading cause of cancer-related deaths with few patients benefiting from biomarker-guided therapy. Mutation expression is…”
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Transcriptional and functional consequences of TP53 splice mutations in colorectal cancer by Smeby, Jørgen, Sveen, Anita, Eilertsen, Ina A., Danielsen, Stine A., Hoff, Andreas M., Eide, Peter W., Johannessen, Bjarne, Hektoen, Merete, Skotheim, Rolf I., Guren, Marianne G., Nesbakken, Arild, Lothe, Ragnhild A.

“…TP53 mutations are common in colorectal cancer (CRC). Most TP53 sequencing studies have been restricted to coding regions, but recent studies have revealed…”
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Exploratory analyses of consensus molecular subtype-dependent associations of TP53 mutations with immunomodulation and prognosis in colorectal cancer by Smeby, Jørgen, Sveen, Anita, Bergsland, Christian H, Eilertsen, Ina A, Danielsen, Stine A, Eide, Peter W, Hektoen, Merete, Guren, Marianne G, Nesbakken, Arild, Bruun, Jarle, Lothe, Ragnhild A

“…BackgroundAccumulating evidence suggests immunomodulatory and context-dependent effects of TP53 mutations in cancer. We performed an exploratory analysis of…”
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Long noncoding RNA MIR31HG is a bona fide prognostic marker with colorectal cancer cell‐intrinsic properties by Eide, Peter W., Eilertsen, Ina A., Sveen, Anita, Lothe, Ragnhild A.

“…Elevated miR‐31 expression is associated with poor outcome in colorectal cancer (CRC). Whether the prognostic information is independent of known molecular…”
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MicroRNAs as growth regulators, their function and biomarker status in colorectal cancer by Cekaite, Lina, Eide, Peter W, Lind, Guro E, Skotheim, Rolf I, Lothe, Ragnhild A

“…Gene expression is in part regulated by microRNAs (miRNAs). This review summarizes the current knowledge of miRNAs in colorectal cancer (CRC); their role as…”
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The E3 ubiquitin ligase NEDD4 induces endocytosis and lysosomal sorting of connexin 43 to promote loss of gap junctions by Totland, Max Z, Bergsland, Christian H, Fykerud, Tone A, Knudsen, Lars M, Rasmussen, Nikoline L, Eide, Peter W, Yohannes, Zeremariam, Sørensen, Vigdis, Brech, Andreas, Lothe, Ragnhild A, Leithe, Edward

“…Intercellular communication via gap junctions has an important role in controlling cell growth and in maintaining tissue homeostasis. Connexin 43 (Cx43; also…”
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Prognostic, predictive, and pharmacogenomic assessments of CDX 2 refine stratification of colorectal cancer by Bruun, Jarle, Sveen, Anita, Barros, Rita, Eide, Peter W., Eilertsen, Ina, Kolberg, Matthias, Pellinen, Teijo, David, Leonor, Svindland, Aud, Kallioniemi, Olli, Guren, Marianne G., Nesbakken, Arild, Almeida, Raquel, Lothe, Ragnhild A.

“…We aimed to refine the value of CDX 2 as an independent prognostic and predictive biomarker in colorectal cancer ( CRC ) according to disease stage and…”
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Abstract 1433: Role of the E3 ubiquitin ligase NEDD4 in the regulation of PTEN and MDM2 in colorectal cancer by Knudsen, Lars M., Sveen, Anita, Andreassen, Christer A., Bergsland, Christian H., Eilertsen, Ina A., Rasmussen, Nikoline L., Totland, Max Z., Eide, Peter W., Bruun, Jarle, Lothe, Ragnhild A., Leithe, Edward

“…Abstract Introduction: NEDD4 (neural precursor cell-expressed developmentally down-regulated 4), a member of the HECT (homologous to E6AP C-terminus) family of…”
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Abstract A19: Modeling intrapatient pharmacotranscriptomic heterogeneity with organoids derived from colorectal cancer liver metastases by Kryeziu, Kushtrim, Bruun, Jarle, Eide, Peter W., Moosavi, Seyed H., Eilertsen, Ina A., Langerud, Jonas, Røsok, Bård, Brunsell, Tuva H., Guren, Marianne G., Abildgaard, Andreas, Nesbakken, Arild, Bjørnbeth, Bjørn Atle, Sveen, Anita, Lothe, Ragnhild A.

“…Abstract Patients with metastatic colorectal cancer (CRC) have few targeted treatment options compared with other major malignancies, and both over- and…”
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