Search Results - "Eid, Ahmed H."
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Caffeic acid and ellagic acid ameliorate adjuvant-induced arthritis in rats via targeting inflammatory signals, chitinase-3-like protein-1 and angiogenesis
Published in Biomedicine & pharmacotherapy (01-02-2019)“…•Caffeic acid and ellagic acid mitigated paw edema and histopathologic aberrations.•Both agents lowered the expression of paw NF-κB, CHI3L1 and IL-1β.•They…”
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Targeting oxidative stress, apoptosis, and autophagy by galangin mitigates cadmium-induced renal damage: Role of SIRT1/Nrf2 and AMPK/mTOR pathways
Published in Life sciences (1973) (15-02-2022)“…Galangin, a bioactive flavonoid with remarkable antioxidant and anti-apoptotic actions, has demonstrated promising amelioration of experimental hepatotoxicity,…”
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Neuroprotective Impact of Linagliptin against Cadmium-Induced Cognitive Impairment and Neuropathological Aberrations: Targeting SIRT1/Nrf2 Axis, Apoptosis, and Autophagy
Published in Pharmaceuticals (Basel, Switzerland) (27-07-2023)“…Cadmium is an environmental contaminant associated with marked neurotoxicity and cognitive impairment. Linagliptin, a dipeptidyl peptidase-4 (DPP-4) inhibitor,…”
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Carvedilol alleviates testicular and spermatological damage induced by cisplatin in rats via modulation of oxidative stress and inflammation
Published in Archives of pharmacal research (01-12-2016)“…The clinical application of the anticancer drug cisplatin is limited by its deleterious side effects, including male reproductive toxicity. In this context,…”
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Repositioning Linagliptin for the Mitigation of Cadmium-Induced Testicular Dysfunction in Rats: Targeting HMGB1/TLR4/NLRP3 Axis and Autophagy
Published in Pharmaceuticals (Basel, Switzerland) (11-07-2022)“…Cadmium, a ubiquitous environmental toxicant, disrupts testicular function and fertility. The dipeptidyl peptidase-4 inhibitor linagliptin has shown pronounced…”
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Topiramate Reprofiling for the Attenuation of Cadmium-Induced Testicular Impairment in Rats: Role of NLRP3 Inflammasome and AMPK/mTOR-Linked Autophagy
Published in Pharmaceuticals (Basel, Switzerland) (01-11-2022)“…Topiramate, a promising drug classically used for the management of neurological disorders including epilepsy and migraine, has demonstrated marked…”
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Stimulation of Autophagy by Dapagliflozin Mitigates Cadmium-Induced Testicular Dysfunction in Rats: The Role of AMPK/mTOR and SIRT1/Nrf2/HO-1 Pathways
Published in Pharmaceuticals (Basel, Switzerland) (01-07-2023)“…Cadmium (Cd) is a widespread environmental pollutant that triggers testicular dysfunction. Dapagliflozin is a selective sodium-glucose co-transporter-2…”
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Targeting Autophagy, Apoptosis, and SIRT1/Nrf2 Axis with Topiramate Underlies Its Neuroprotective Effect against Cadmium-Evoked Cognitive Deficits in Rats
Published in Pharmaceuticals (Basel, Switzerland) (29-08-2023)“…Cadmium is an environmental toxicant that instigates cognitive deficits with excessive glutamate excitatory neuroactivity in the brain. Topiramate, a glutamate…”
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Activation of AMPK/mTOR-Driven Autophagy and Suppression of the HMGB1/TLR4 Pathway with Pentoxifylline Attenuates Doxorubicin-Induced Hepatic Injury in Rats
Published in Pharmaceuticals (Basel, Switzerland) (26-05-2024)“…Despite being an effective chemotherapeutic agent, the clinical use of doxorubicin (DOX) is limited by several organ toxicities including hepatic injury…”
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Targeting Autophagy, Apoptosis, and Oxidative Perturbations with Dapagliflozin Mitigates Cadmium-Induced Cognitive Dysfunction in Rats
Published in Biomedicines (01-11-2023)“…Cognitive decline and Alzheimer-like neuropathology are common manifestations of cadmium toxicity. Thanks to its antioxidant/anti-apoptotic features,…”
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Targeting MAPKs, NF‐κB, and PI3K/AKT pathways by methyl palmitate ameliorates ethanol‐induced gastric mucosal injury in rats
Published in Journal of cellular physiology (01-12-2019)“…Excessive drinking of alcohol has been frequently associated with gastric injury; however, its underlying molecular mechanisms have been inadequately…”
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Linagliptin mitigates experimental inflammatory bowel disease in rats by targeting inflammatory and redox signaling
Published in Life sciences (1973) (15-05-2021)“…Dipeptidyl peptidase-4 (DPP-4) has been involved in the pathogenesis of inflammatory bowel diseases (IBD), yet the underlying mechanisms remain inconclusive…”
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Ellagic acid attenuates testicular disruption in rheumatoid arthritis via targeting inflammatory signals, oxidative perturbations and apoptosis
Published in Life sciences (1973) (15-12-2019)“…Reduced male fertility has been regarded as a serious complication of rheumatoid arthritis. Phytochemicals have been described as protective agents against…”
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Venlafaxine and carvedilol ameliorate testicular impairment and disrupted spermatogenesis in rheumatoid arthritis by targeting AMPK/ERK and PI3K/AKT/mTOR pathways
Published in Toxicology and applied pharmacology (01-02-2019)“…Testicular impairment has been commonly described in long-standing rheumatoid arthritis (RA) patients. Since depression and cardiovascular disorders are the…”
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Irbesartan reprofiling for the amelioration of ethanol-induced gastric mucosal injury in rats: Role of inflammation, apoptosis, and autophagy
Published in Life sciences (1973) (01-11-2022)“…Pronounced anti-inflammatory and anti-apoptotic features have been characterized for the angiotensin receptor blocker irbesartan. Yet, its effect on…”
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Activation of autophagy by sitagliptin attenuates cadmium-induced testicular impairment in rats: Targeting AMPK/mTOR and Nrf2/HO-1 pathways
Published in Life sciences (1973) (15-03-2021)“…Cadmium (Cd) is a prevalent environmental contaminant that incurs deleterious health effects, including testicular impairment. Sitagliptin, a selective…”
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Camel’s milk ameliorates TNBS-induced colitis in rats via downregulation of inflammatory cytokines and oxidative stress
Published in Food and chemical toxicology (01-07-2014)“…[Display omitted] •Camel’s milk (CM) possesses promising alleviating effects against TNBS-induced colitis.•CM suppressed colon injury, macro- and microscopic…”
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Targeting inflammation, autophagy, and apoptosis by troxerutin attenuates methotrexate-induced renal injury in rats
Published in International immunopharmacology (01-02-2022)“…[Display omitted] •Troxerutin attenuated renal immune cell infiltration and kidney function markers.•It inhibited HMGB1/RAGE/NF-κB pathway and its downstream…”
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Inhibition of oxidative stress and apoptosis by camel milk mitigates cyclosporine‐induced nephrotoxicity: Targeting Nrf2/HO‐1 and AKT/eNOS/NO pathways
Published in Food science & nutrition (01-06-2021)“…Cyclosporine (CsA) is a widely used immunosuppressive agent that incurs marked nephrotoxicity in the clinical setting. Thus, there is a need for finding…”
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Characterization of Electrophotographic Print Artifacts: Banding, Jitter, and Ghosting
Published in IEEE transactions on image processing (01-05-2011)“…Electrophotographic (EP) print banding, jitter, and ghosting artifacts are common sources of print quality degradation. Traditionally, the characterization of…”
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