Search Results - "Eichler, Duane C"

Argininosuccinate Synthase Expression Is Required to Maintain Nitric Oxide Production and Cell Viability in Aortic Endothelial Cells by Goodwin, Bonnie L, Solomonson, Larry P, Eichler, Duane C

“…Although cellular levels of arginine greatly exceed the apparent K m for endothelial nitric-oxide synthase, current evidence suggests that the bulk of this…”
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Argininosuccinate synthase: at the center of arginine metabolism by Haines, Ricci J, Pendleton, Laura C, Eichler, Duane C

“…The levels of L-arginine, a cationic, semi-essential amino acid, are often controlled within a cell at the level of local availability through biosynthesis…”
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Regulation of Endothelial Argininosuccinate Synthase Expression and NO Production by an Upstream Open Reading Frame by Pendleton, Laura C., Goodwin, Bonnie L., Solomonson, Larry P., Eichler, Duane C.

“…Argininosuccinate synthase (AS) catalyzes the rate-limiting step in the recycling of citrulline to arginine, which in endothelial cells, is tightly coupled to…”
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Endothelial nitric oxide production is tightly coupled to the citrulline–NO cycle by Flam, Brenda R., Eichler, Duane C., Solomonson, Larry P.

“…Nitric oxide (NO) is an important vasorelaxant produced along with l-citrulline from l-arginine in a reaction catalyzed by endothelial nitric oxide synthase…”
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Tumor necrosis factor-alpha reduces argininosuccinate synthase expression and nitric oxide production in aortic endothelial cells by Goodwin, Bonnie L, Pendleton, Laura C, Levy, Monique M, Solomonson, Larry P, Eichler, Duane C

“…Endothelial dysfunction associated with elevated serum levels of TNF-alpha observed in diabetes, obesity, and congenital heart disease results, in part, from…”
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Protein Kinase Cα Phosphorylates a Novel Argininosuccinate Synthase Site at Serine 328 during Calcium-dependent Stimulation of Endothelial Nitric-oxide Synthase in Vascular Endothelial Cells by Haines, Ricci J., Corbin, Karen D., Pendleton, Laura C., Eichler, Duane C.

“…Background: Argininosuccinate synthase (AS) is critical for endothelial nitric oxide production, yet little is known about its regulation. Results: AS Ser-328…”
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Insulin transcriptionally regulates argininosuccinate synthase to maintain vascular endothelial function by Haines, Ricci J., Corbin, Karen D., Pendleton, Laura C., Meininger, Cynthia J., Eichler, Duane C.

“…► Comparison of insulin effects on argininosuccinate synthase and eNOS expression. ► Insulin treatment restores argininosuccinate synthase mRNA expression. ►…”
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Stimulation of Receptor-Mediated Nitric Oxide Production by Vanadate by Hellermann, Gary R, Flam, Brenda R, Eichler, Duane C, Solomonson, Larry P

“…Nitric oxide (NO) production by endothelial cells in response to bradykinin (Bk) treatment was markedly and synergistically enhanced by cotreatment with sodium…”
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The caveolar nitric oxide synthase/arginine regeneration system for NO production in endothelial cells by Solomonson, Larry P, Flam, Brenda R, Pendleton, Laura C, Goodwin, Bonnie L, Eichler, Duane C

“…The enzyme endothelial nitric oxide synthase (eNOS) catalyzes the conversion of arginine, oxygen and NADPH to NO and citrulline. Previous results suggest an…”
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Phosphorylation of argininosuccinate synthase by protein kinase A by Corbin, Karen D., Pendleton, Laura C., Solomonson, Larry P., Eichler, Duane C.

“…Argininosuccinate synthase (AS) is essential for endothelial nitric oxide (NO) production and its regulation in this capacity has been studied primarily at the…”
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Citrulline Can Preserve Proliferation and Prevent the Loss of CD3 ζ Chain Under Conditions of Low Arginine by Bansal, Vishal, Rodriguez, Paulo, Wu, Guoyao, Eichler, Duane C., Zabaleta, Jovanny, Taheri, Faramarz, Ochoa, Juan B.

“…Background: Arginine depletion by the enzyme Arginase I, decreases expression of the TCR ζ chain preventing T-cell activation and causing T-cell dysfunction…”
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Troglitazone up-regulates vascular endothelial argininosuccinate synthase by Goodwin, Bonnie L., Corbin, Karen D., Pendleton, Laura C., Levy, Monique M., Solomonson, Larry P., Eichler, Duane C.

“…Vascular endothelial nitric oxide (NO) production via the citrulline–NO cycle not only involves the regulation of endothelial nitric oxide synthase (eNOS), but…”
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Endothelial argininosuccinate synthase mRNA 5'-untranslated region diversity. Infrastructure for tissue-specific expression by Pendleton, Laura C, Goodwin, Bonnie L, Flam, Brenda R, Solomonson, Larry P, Eichler, Duane C

“…Based on the integral role that argininosuccinate synthase (AS) plays in the production of nitric oxide in vascular endothelial cells and urea in liver, an…”
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The Protein Kinase C βII Exon Confers mRNA Instability in the Presence of High Glucose Concentrations by Patel, Niketa A., Eichler, Duane C., Chappell, David S., Illingworth, Philip A., Chalfant, Charles E., Yamamoto, Mayumi, Dean, Nicholas M., Wyatt, Jacqueline R., Mebert, Konrad, Watson, James E., Cooper, Denise R.

“…Previous studies showed that short term exposure of cells to high glucose destabilized protein kinase C (PKC) βII mRNA, whereas PKCβI mRNA levels remained…”
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Leptin and the Adipocyte Endocrine System by Diamond, Frank B., Eichler, Duane C.

“…Although adipose tissue has long been considered to be metabolically passive and primarily responsible for energy storage, recent scientific advances have…”
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Phosphorylation of argininosuccinate synthase at T131 correlates with changes in NO production by Pendleton, Laura C, Haines, Ricci J, Corbin, Karen D, Eichler, Duane C

“…Abstract only The citrulline‐nitric oxide cycle is a tightly regulated system for the production of nitric oxide (NO) in vascular endothelial cells…”
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Characterization of a putative AS regulatory phosphorylation site implicated in vascular endothelial nitric oxide production by Thompson, Ricci, Corbin, Karen, Pendleton, Laura, Eichler, Duane C.

“…Argininosuccinate synthase (AS) catalyzes the rate‐limiting step of the nitric oxide (NO) cycle in vascular endothelial cells (EC); however, little is known…”
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Leptin: molecular biology, physiology, and relevance to pediatric practice by Diamond, Jr, F B, Eichler, D C

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Insulin Coordinately Regulates Nitric Oxide Synthase and Argininosuccinate Synthase to Maintain Vascular Endothelial Function by Pendleton, Laura C, Thompson, Ricci J, Corbin, Karen D, Meininger, Cynthia J, Eichler, Duane C

“…The pathogenesis of diabetes includes impairment of vascular endothelial cell nitric oxide (NO) production. In this report, we demonstrate that insulin not…”
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Characterization of AS Regulatory Protein, a Novel Protein Implicated in Endothelial Stress Response by Pendleton, Laura C., Corbin, Karen D., Shriver, Sandra K., Solomonson, Larry P., Eichler, Duane C.

“…Abstract only…”
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