Search Results - "Eichin, Felix"
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RNA cytosine methyltransferase Nsun3 regulates embryonic stem cell differentiation by promoting mitochondrial activity
Published in Cellular and molecular life sciences : CMLS (01-04-2018)Get full text
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Polyploidy control in hepatic health and disease
Published in Journal of hepatology (01-11-2021)“…A balanced increase in DNA content (ploidy) is observed in some human cell types, including bone-resorbing osteoclasts, platelet-producing megakaryocytes,…”
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SAFB2 Enables the Processing of Suboptimal Stem-Loop Structures in Clustered Primary miRNA Transcripts
Published in Molecular cell (04-06-2020)“…Many microRNAs (miRNAs) are generated from primary transcripts containing multiple clustered stem-loop structures that are thought to be recognized and cleaved…”
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RNA cytosine methyltransferase Nsun3 regulates embryonic stem cell differentiation by promoting mitochondrial activity
Published in Cellular and molecular life sciences : CMLS (01-04-2018)“…Chemical modifications of RNA have been attracting increasing interest because of their impact on RNA fate and function. Therefore, the characterization of…”
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Chronic spindle assembly checkpoint activation causes myelosuppression and gastrointestinal atrophy
Published in EMBO reports (12-06-2024)“…Interference with microtubule dynamics in mitosis activates the spindle assembly checkpoint (SAC) to prevent chromosome segregation errors. The SAC induces…”
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PIDDosome-SCAP crosstalk controls high-fructose-diet-dependent transition from simple steatosis to steatohepatitis
Published in Cell metabolism (04-10-2022)“…Sterol deficiency triggers SCAP-mediated SREBP activation, whereas hypernutrition together with ER-stress activate SREBP1/2 via caspase-2. Whether these…”
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E2F-Family Members Engage the PIDDosome to Limit Hepatocyte Ploidy in Liver Development and Regeneration
Published in Developmental cell (10-02-2020)“…E2F transcription factors control the cytokinesis machinery and thereby ploidy in hepatocytes. If or how these proteins limit proliferation of polyploid cells…”
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