Search Results - "Eicher, Thomas"

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    Coupling of remote alternating-access transport mechanisms for protons and substrates in the multidrug efflux pump AcrB by Eicher, Thomas, Seeger, Markus A, Anselmi, Claudio, Zhou, Wenchang, Brandstätter, Lorenz, Verrey, François, Diederichs, Kay, Faraldo-Gómez, José D, Pos, Klaas M

    Published in eLife (19-09-2014)
    “…Membrane transporters of the RND superfamily confer multidrug resistance to pathogenic bacteria, and are essential for cholesterol metabolism and embryonic…”
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    Journal Article
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    Structural Asymmetry of AcrB Trimer Suggests a Peristaltic Pump Mechanism by Seeger, Markus A, Schiefner, André, Eicher, Thomas, Verrey, François, Diederichs, Kay, Pos, Klaas M

    “…The AcrA/AcrB/TolC complex spans the inner and outer membranes of Escherichia coli and serves as its major drug-resistance pump. Driven by the proton motive…”
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    Journal Article
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    Engineered disulfide bonds support the functional rotation mechanism of multidrug efflux pump AcrB by Diederichs, Kay, von Ballmoos, Christoph, Brandstätter, Lorenz, Verrey, François, Seeger, Markus A, Pos, Klaas M, Eicher, Thomas

    Published in Nature structural & molecular biology (01-02-2008)
    “…The AcrA–AcrB–TolC complex is the major multidrug efflux pump in Escherichia coli . The asymmetric structure of the trimeric inner-membrane component AcrB…”
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    Journal Article
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    The AcrB efflux pump: conformational cycling and peristalsis lead to multidrug resistance by Seeger, Markus A, Diederichs, Kay, Eicher, Thomas, Brandstätter, Lorenz, Schiefner, André, Verrey, François, Pos, Klaas M

    Published in Current drug targets (01-09-2008)
    “…Antimicrobial resistance of human pathogenic bacteria is an emerging problem for global public health. This resistance is often associated with the…”
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    Journal Article
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    Analysis of AcrB and AcrB/DARPin ligand complexes by LILBID MS by Brandstätter, Lorenz, Sokolova, Lucie, Eicher, Thomas, Seeger, Markus A., Briand, Christophe, Cha, Hi-jea, Cernescu, Mihaela, Bohnert, Jürgen, Kern, Winfried V., Brutschy, Bernd, Pos, Klaas M.

    Published in Biochimica et biophysica acta (01-09-2011)
    “…The AcrA/AcrB/TolC complex is responsible for intrinsic multidrug resistance (MDR) in Escherichia coli. Together with the periplasmic adaptor protein AcrA and…”
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    Journal Article
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    Structural and functional aspects of the multidrug efflux pump AcrB by Eicher, Thomas, Brandstätter, Lorenz, Pos, Klaas M

    Published in Biological chemistry (01-08-2009)
    “…The tripartite efflux system AcrA/AcrB/TolC is the main pump in Escherichia coli for the efflux of multiple antibiotics, dyes, bile salts and detergents. The…”
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    Journal Article
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