Search Results - "Eichberg, J."

Lessons Learned from the Development and Roll-Out of the rVSVΔG-ZEBOV-GP Zaire ebolavirus Vaccine to Inform Marburg Virus and Sudan ebolavirus Vaccines by Coller, Beth-Ann G., Lapps, William, Yunus, Mahum, Bruno, Samantha, Eichberg, Michael J., Lee, Andrew Wen-Tseng, Liu, Kenneth, Drury, Rosybel, Millogo, Jules, Macareo, Louis Robert, Armstrong, Thomas H., Blue, Jeffrey T., Isopi, Lynne A., Hughes, Melissa, VanRheenen, Susan M., Deutsch, Jonathan, Tell, Joan G., Dubey, Sheri A.

“…This review describes key aspects of the development of the rVSVΔG-ZEBOV-GP Ebola vaccine and key activities which are continuing to further expand our…”
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Approaches to the Synthesis of (±)-Strychnine via the Cobalt-Mediated [2 + 2 + 2] Cycloaddition:  Rapid Assembly of a Classic Framework by Eichberg, Michael J, Dorta, Rosa L, Grotjahn, Douglas B, Lamottke, Kai, Schmidt, Martin, Vollhardt, K. Peter C

“…Five synthetic approaches to racemic strychnine (1), with the cobalt-mediated [2 + 2 + 2] cycloaddition of alkynes to indoles as the key step, are described…”
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Cobalt-Mediated [2+2+2] Cycloaddition versus CH and NH Activation of Pyridones and Pyrazinones with Alkynes: An Experimental Study by Aubert, Corinne, Betschmann, Patrick, Eichberg, Michael J., Gandon, Vincent, Heckrodt, Thilo J., Lehmann, Jürg, Malacria, Max, Masjost, Birgit, Paredes, Elisa, Vollhardt, K. Peter C., Whitener, Glenn D.

“…The reactivity of a range of pyridone and pyrazinone derivatives towards alkynes in the presence of cyclopentadienylcobaltbis(ethene) has been investigated…”
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The Formal Total Synthesis of (±)-Strychnine via a Cobalt-Mediated [2 + 2 + 2]Cycloaddition by Eichberg, Michael J, Dorta, Rosa L, Lamottke, Kai, Vollhardt, K. Peter C

“…A short, highly convergent total synthesis of racemic isostrychnine, and thus strychnine, has been completed. The route involves 14 steps in the longest linear…”
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The Thermal Retro[2+2+2]cycloaddition of Cyclohexane Activated by Triscyclobutenannelation: Concerted All-Disrotatory versus Stepwise Conrotatory Pathways to Fused [12]Annulenes by Eichberg, Michael J., Houk, K. N., Lehmann, Jürg, Leonard, Philip W., Märker, Anne, Norton, Joseph E., Sawicka, Dorota, Vollhardt, K. Peter C., Whitener, Glenn D., Wolff, Stefan

“…All dis or all con? While benzo analogues 2–4 undergo cycloreversion of the central cyclohexane ring by all‐disrotatory opening, the triscyclobutenocyclohexane…”
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Global blood miRNA profiling unravels early signatures of immunogenicity of Ebola vaccine rVSVΔG-ZEBOV-GP by Vianello, Eleonora, Persson, Josefine, Andersson, Björn, van Veen, Suzanne, Dias, Thomaz Lüscher, Santoro, Francesco, Östensson, Malin, Obudulu, Ogonna, Agbajogu, Christopher, Torkzadeh, Sara, Agnandji, Selidji Todagbe, Ahmed, Rafi, Anderson, Jenna, Auderset, Floriane, Bejon, Philip, Borgianni, Luisa, Brosnahan, Jessica, Ciabattini, Annalisa, Engler, Olivier, Haks, Marielle C., Harandi, Ali M., Heppner, Donald Gray, Gerlini, Alice, Huttner, Angela, Kremsner, Peter G., Medaglini, Donata, Monath, Thomas, Ndungu, Francis, Njuguna, Patricia, Ottenhoff, Tom H.M., Pejoski, David, Page, Mark, Pozzi, Gianni, Santoro, Francesco, Siegrist, Claire-Anne, Dubey, Sheri, Eichberg, Micheal J., Gonzalez-Dias, Patrícia, Essone, Paulin Ndong, Kabwende, Lumeka, Kremsner, Peter Gottfried, Nakaya, Helder, Nakka, Sravya S., Haks, Mariëlle C., Persson, Josefine, Rothenberger, Sylvia, van Veen, Suzanne, Vianello, Eleonora, Nakaya, Helder I., Medaglini, Donata, Siegrist, Claire-Anne, Ottenhoff, Tom H.M., Harandi, Ali M.

“…The vectored Ebola vaccine rVSVΔG-ZEBOV-GP elicits protection against Ebola Virus Disease (EVD). In a study of forty-eight healthy adult volunteers who…”
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Public funding of clinical-stage antibiotic development in the United States and European Union by Eichberg, Michael J

“…The health and national security challenge of antibiotic resistance has led governments to adopt policies to stimulate new antibiotic R&D. Government programs…”
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Prevention of HIV-1 infection in chimpanzees by gpl20 V3 domain-specific monoclonal antibody by Emini, E. A, Schleif, W. A, Nunberg, J. H, Conley, A. J, Eda, Y, Tokiyoshi, S, Putney, S. D, Matsushrta, S, Cobb, K. E, Jett, C. M, Eichberg, J. W, Murthy, K. K

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Protection of chimpanzees from infection by HIV-1 after vaccination with recombinant glycoprotein gp120 but not gp160 by Berman, Phillip W, Gregory, Timothy J, Riddle, Lavon, Nakamura, Gerald R, Champe, Mark A, Porter, James P, Wurm, Florain M, Hershberg, Robert D, Cobb, E. Kathy, Eichberg, Jorg W

“…The development of a vaccine to provide protective immunity to human immunodeficiency virus type 1 (HIV-1), the virus causing AIDS, would be the most practical…”
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Redefining the HIV-infectious window period in the chimpanzee model: evidence to suggest that viral nucleic acid testing can prevent blood-borne transmission by Murthy, K.K., Henrard, D.R., Eichberg, J.W., Cobb, K.E., Busch, M.P., Allain, J.P., Alter, H.J.

“…BACKGROUND: Although it is rare, blood‐transmitted HIV infection can occur when a donor presents in the window period between HIV‐1 exposure and the first…”
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Prevention of HIV infection by passive immunization with HIV immunoglobulin by Prince, A M, Reesink, H, Pascual, D, Horowitz, B, Hewlett, I, Murthy, K K, Cobb, K E, Eichberg, J W

“…The use of a human immunodeficiency virus (HIV) immune globulin (HIVIG) in prevention of HIV infection in chimpanzees was investigated in the hope of ultimate…”
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Native but not denatured recombinant human immunodeficiency virus type 1 gp120 generates broad-spectrum neutralizing antibodies in baboons by Haigwood, N L, Nara, P L, Brooks, E, Van Nest, G A, Ott, G, Higgins, K W, Dunlop, N, Scandella, C J, Eichberg, J W, Steimer, K S

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Prevention of HIV-1 infection in chimpanzees by gp120 V3 domain-specific monoclonal antibody by EMINI, E. A, SCHLEIF, W. A, EICHBERG, J. W, MURTHY, K. K, NUNBERGB, J. H, CONLEY, A. J, EDA, Y, TOKIYOSHI, S, PUTNEY, S. D, MATSUSHITA, S, COBB, K. E, JETT, C. M

“…The acquired immunodeficiency syndrome (AIDS) is the late-stage clinical manifestation of long-term persistent infection with the human immunodeficiency virus…”
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A Myo-Inositol Pool Utilized for Phosphatidylinositol Synthesis is Depleted in Sciatic Nerve from Rats with Streptozotocin-Induced Diabetes by Zhu, Xi, Eichberg, Joseph

“…Peripheral nerve from experimentally diabetic rats exhibits lowered levels of myo-inositol (MI) and decreased incorporation of [3H]MI into phosphatidylinositol…”
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Characterization of receptors involved in dopamine-induced activation of phospholipase-C in rat renal cortex by Vyas, S J, Eichberg, J, Lokhandwala, M F

“…Dopamine (DA) is reported to stimulate phospholipase-C (PL-C) in rat renal cortex. Inasmuch as DA activates alpha adrenoceptors and DA receptors, the relative…”
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Cloned hepatitis delta virus cDNA is infectious in the chimpanzee by SUREAU, C, TAYLOR, J, MEI CHAO, EICHBERG, J. W, LANFORD, R. E

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Antibody-Dependent Enhancement of Human Immunodeficiency Virus Type 1 (HIV-1) Infection in vitro by Serum from HIV-1-Infected and Passively Immunized Chimpanzees by Robinson, W. Edward, Montefiori, David C., Mitchell, William M., Prince, Alfred M., Alter, Harvey J., Dreesman, Gordon R., Eichberg, Jorg W.

“…Based on recent reports of antibody-dependent enhancement of human immunodeficiency virus type 1 (HIV-1) infection in vitro by serum from HIV-1-infected…”
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Effect of immunization with a vaccinia-HIV env recombinant on HIV infection of chimpanzees by Hu, Shiu-Lok, Fultz, Patricia N, McClure, Harold M, Eichberg, Jorg W, Thomas, Elaine Kinney, Zarling, Joyce, Singhal, Mitra C, Kosowski, Steven G, Swenson, R. Brent, Anderson, Daniel C, Todaro, George

“…Acquired immunodeficiency syndrome (AIDS) is caused by human immunodeficiency virus (HIV) and is now recognized as a worldwide epidemic for which there is no…”
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Transmission of HTLV-III Infection from Human Plasma to Chimpanzees: An Animal Model for AIDS by Alter, Harvey J., Eichberg, Jorg W., Masur, Henry, Saxinger, W. Carl, Gallo, Robert, Macher, Abe M., Lane, H. Clifford, Fauci, Anthony S.

“…Two of three chimpanzees given plasma from patients with acquired immune deficiency syndrome (AIDS) or pre-AIDS showed serum antibodies to type III human…”
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Synthesis, Structure, and Fluxionality of (μ-Diphenylsilylene)(fulvalene)tetracarbonyldirhenium Double Si−H Activation to the First Fulvalene Silylene Complex by Kayser, Bernd, Eichberg, Michael J, Vollhardt, K. Peter C

“…(Fulvalene)hexacarbonyldirhenium (1) furnishes the first silylene fulvalenedimetal complex 3 by double Si−H activation. The solid-state structure of the…”
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