Search Results - "Eich, Christina"

Recent Advances in Rare-Earth-Doped Nanoparticles for NIR-II Imaging and Cancer Theranostics by Yu, Zhenfeng, Eich, Christina, Cruz, Luis J.

“…Fluorescence imaging in the second near infrared window (NIR-II, 1,000-1,700 nm) has been widely used in cancer diagnosis and treatment due to its high spatial…”
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PLGA-Nanoparticles for Intracellular Delivery of the CRISPR-Complex to Elevate Fetal Globin Expression in Erythroid Cells by Cruz, Luis J., van Dijk, Thamar, Vepris, Olena, Li, Tracy M.W.Y., Schomann, Timo, Baldazzi, Fabio, Kurita, Ryo, Nakamura, Yukio, Grosveld, Frank, Philipsen, Sjaak, Eich, Christina

“…Ex vivo gene editing of CD34+ hematopoietic stem and progenitor cells (HSPCs) offers great opportunities to develop new treatments for a number of malignant…”
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Functionalized Nanoparticles Targeting Tumor-Associated Macrophages as Cancer Therapy by He, Yuanyuan, de Araújo Júnior, Raimundo Fernandes, Cruz, Luis J, Eich, Christina

“…The tumor microenvironment (TME) plays a central role in regulating antitumor immune responses. As an important part of the TME, alternatively activated type 2…”
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Multifunctional Role of Lipids in Modulating the Tumorigenic Properties of 4T1 Breast Cancer Cells by He, Yuanyuan, Rezaei, Somayeh, Júnior, Raimundo Fernandes de Araújo, Cruz, Luis J, Eich, Christina

“…Tumor growth and progression are linked to an altered lipid metabolism in the tumor microenvironment (TME), including tumor cells and tumor-associated…”
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Isolation and high-dimensional flow cytometric analysis of tumor-infiltrating leukocytes in a mouse model of colorectal cancer by Eich, Christina, Vogt, Johannes F, Längst, Vivian, Clausen, Björn E, Hövelmeyer, Nadine

“…Colorectal cancer (CRC) is a complex and heterogeneous disease characterized by dysregulated interactions between tumor cells and the immune system. The tumor…”
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Changes in membrane sphingolipid composition modulate dynamics and adhesion of integrin nanoclusters by Eich, Christina, Manzo, Carlo, Keijzer, Sandra de, Bakker, Gert-Jan, Reinieren-Beeren, Inge, García-Parajo, Maria F., Cambi, Alessandra

“…Sphingolipids are essential constituents of the plasma membrane (PM) and play an important role in signal transduction by modulating clustering and dynamics of…”
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In vivo single cell analysis reveals Gata2 dynamics in cells transitioning to hematopoietic fate by Eich, Christina, Arlt, Jochen, Vink, Chris S, Solaimani Kartalaei, Parham, Kaimakis, Polynikis, Mariani, Samanta A, van der Linden, Reinier, van Cappellen, Wiggert A, Dzierzak, Elaine

“…Cell fate is established through coordinated gene expression programs in individual cells. Regulatory networks that include the Gata2 transcription factor play…”
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Nanoparticles targeting hematopoietic stem and progenitor cells: Multimodal carriers for the treatment of hematological diseases by Cruz, Luis J., Rezaei, Somayeh, Grosveld, Frank, Philipsen, Sjaak, Eich, Christina

“…Modern-day hematopoietic stem cell (HSC) therapies, such as gene therapy, modify autologous HSCs prior to re-infusion into myelo-conditioned patients and hold…”
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Autologous patient-derived exhausted nano T-cells exploit tumor immune evasion to engage an effective cancer therapy by Blaya-Cánovas, José L, Griñán-Lisón, Carmen, Blancas, Isabel, Marchal, Juan A, Ramírez-Tortosa, César, López-Tejada, Araceli, Benabdellah, Karim, Cortijo-Gutiérrez, Marina, Cano-Cortés, M Victoria, Graván, Pablo, Navarro-Marchal, Saúl A, Gómez-Morales, Jaime, Delgado-Almenta, Violeta, Calahorra, Jesús, Agudo-Lera, María, Sagarzazu, Amaia, Rodríguez-González, Carlos J, Gallart-Aragón, Tania, Eich, Christina, Sánchez-Martín, Rosario M, Granados-Principal, Sergio

“…Active targeting by surface-modified nanoplatforms enables a more precise and elevated accumulation of nanoparticles within the tumor, thereby enhancing drug…”
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Functional and molecular characterization of mouse Gata2-independent hematopoietic progenitors by Kaimakis, Polynikis, de Pater, Emma, Eich, Christina, Solaimani Kartalaei, Parham, Kauts, Mari-Liis, Vink, Chris S., van der Linden, Reinier, Jaegle, Martine, Yokomizo, Tomomasa, Meijer, Dies, Dzierzak, Elaine

“…The Gata2 transcription factor is a pivotal regulator of hematopoietic cell development and maintenance, highlighted by the fact that Gata2 haploinsufficiency…”
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Lateral mobility of individual integrin nanoclusters orchestrates the onset for leukocyte adhesion by Bakker, Gert Jan, Eich, Christina, Torreno-Pina, Juan A, Diez-Ahedo, Ruth, Perez-Samper, Gemma, van Zanten, Thomas S, Figdor, Carl G, Cambi, Alessandra, Garcia-Parajo, Maria F

“…Integrins are cell membrane adhesion receptors involved in morphogenesis, immunity, tissue healing, and metastasis. A central, yet unresolved question…”
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Achieving Effective Multimodal Imaging with Rare-Earth Ion-Doped CaF2 Nanoparticles by Yu, Zhenfeng, He, Yuanyuan, Schomann, Timo, Wu, Kefan, Hao, Yang, Suidgeest, Ernst, Zhang, Hong, Eich, Christina, Cruz, Luis

“…Nowadays, cancer poses a significant hazard to humans. Limitations in early diagnosis techniques not only result in a waste of healthcare resources but can…”
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Rare-Earth-Metal (Nd3+, Ce3+ and Gd3+)-Doped CaF2: Nanoparticles for Multimodal Imaging in Biomedical Applications by Yu, Zhenfeng, He, Yuanyuan, Schomann, Timo, Wu, Kefan, Hao, Yang, Suidgeest, Ernst, Zhang, Hong, Eich, Christina, Cruz, Luis J.

“…Here, we describe the synthesis of a novel type of rare-earth-doped nanoparticles (NPs) for multimodal imaging, by combining the rare-earth elements Ce, Gd and…”
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Correction: Yu et al. Achieving Effective Multimodal Imaging with Rare-Earth Ion-Doped CaF2 Nanoparticles. Pharmaceutics 2022, 14, 840 by Yu, Zhenfeng, He, Yuanyuan, Schomann, Timo, Wu, Kefan, Hao, Yang, Suidgeest, Ernst, Zhang, Hong, Eich, Christina, Cruz, Luis J.

“…There was an error in the original publication [...]…”
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Correction: Yu et al. Rare-Earth-Metal (Nd3+, Ce3+ and Gd3+)-Doped CaF2: Nanoparticles for Multimodal Imaging in Biomedical Applications. Pharmaceutics 2022, 14, 2796 by Yu, Zhenfeng, He, Yuanyuan, Schomann, Timo, Wu, Kefan, Hao, Yang, Suidgeest, Ernst, Zhang, Hong, Eich, Christina, Cruz, Luis J.

“…In the original publication [...]…”
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Optically Coupled PtOEP and DPA Molecules Encapsulated into PLGA-Nanoparticles for Cancer Bioimaging by Vepris, Olena, Eich, Christina, Feng, Yansong, Fuentes, Gastón, Zhang, Hong, Kaijzel, Eric L, Cruz, Luis J

“…Triplet-triplet annihilation upconversion (TTA-UC) nanoparticles (NPs) have emerged as imaging probes and therapeutic probes in recent years due to their…”
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Proteome Based Construction of the Lymphocyte Function-Associated Antigen 1 (LFA-1) Interactome in Human Dendritic Cells by Eich, Christina, Lasonder, Edwin, Cruz, Luis J, Reinieren-Beeren, Inge, Cambi, Alessandra, Figdor, Carl G, Buschow, Sonja I

“…The β2-integrin lymphocyte function-associated antigen 1 (LFA-1) plays an important role in the migration, adhesion and intercellular communication of…”
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SMAD1 and SMAD5 Expression Is Coordinately Regulated by FLI1 and GATA2 during Endothelial Development by Marks-Bluth, Jonathon, Khanna, Anchit, Chandrakanthan, Vashe, Thoms, Julie, Bee, Thomas, Eich, Christina, Kang, Young Chan, Knezevic, Kathy, Qiao, Qiao, Fitch, Simon, Oxburgh, Leif, Ottersbach, Katrin, Dzierzak, Elaine, de Bruijn, Marella F. T. R., Pimanda, John E.

“…The bone morphogenetic protein (BMP)/SMAD signaling pathway is a critical regulator of angiogenic sprouting and is involved in vascular development in the…”
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Ceramide and palmitic acid inhibit macrophage-mediated epithelial–mesenchymal transition in colorectal cancer by de Araujo Junior, Raimundo Fernandes, Eich, Christina, Jorquera, Carla, Schomann, Timo, Baldazzi, Fabio, Chan, Alan B., Cruz, Luis J.

“…Accumulating evidence indicates that ceramide (Cer) and palmitic acid (PA) possess the ability to modulate switching of macrophage phenotypes and possess…”
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Controlled release of antigen and Toll-like receptor ligands from PLGA nanoparticles enhances immunogenicity by Cruz, Luis J, Tacken, Paul J, Eich, Christina, Rueda, Felix, Torensma, Ruurd, Figdor, Carl G

“…Dendritic cells rapidly capture nanoparticles and induce a potent cellular immune response. It is yet unknown whether the immunological response induced by…”
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