Search Results - "Ehses, J. A."

IL-1 antagonism reduces hyperglycemia and tissue inflammation in the type 2 diabetic GK rat by Ehses, J.A, Lacraz, G, Giroix, M.-H, Schmidlin, F, Coulaud, J, Kassis, N, Irminger, J.-C, Kergoat, M, Portha, B, Homo-Delarche, F, Donath, M.Y

“…Recent studies suggest an inflammatory process, characterized by local cytokine/chemokine production and immune cell infiltration, regulates islet dysfunction…”
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Toll-like receptor 2-deficient mice are protected from insulin resistance and beta cell dysfunction induced by a high-fat diet by Ehses, J. A, Meier, D. T, Wueest, S, Rytka, J, Boller, S, Wielinga, P. Y, Schraenen, A, Lemaire, K, Debray, S, Van Lommel, L, Pospisilik, J. A, Tschopp, O, Schultze, S. M, Malipiero, U, Esterbauer, H, Ellingsgaard, H, Rütti, S, Schuit, F. C, Lutz, T. A, Böni-Schnetzler, M, Konrad, D, Donath, Marc Y

“…Aims/hypothesis Inflammation contributes to both insulin resistance and pancreatic beta cell failure in human type 2 diabetes. Toll-like receptors (TLRs) are…”
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Hypercholesterolaemia, signs of islet microangiopathy and altered angiogenesis precede onset of type 2 diabetes in the Goto–Kakizaki (GK) rat by Giroix, M-H., Irminger, J-C., Lacraz, G., Noll, C., Calderari, S., Ehses, J. A., Coulaud, J., Cornut, M., Kassis, N., Schmidlin, F., Paul, J-L., Kergoat, M., Janel, N., Halban, P. A., Homo-Delarche, F.

“…Aims/hypothesis The adult non-obese Goto–Kakizaki (GK) rat model of type 2 diabetes, particularly females, carries in addition to hyperglycaemia a genetic…”
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Insulitis in type 2 diabetes by Böni-Schnetzler, M., Ehses, J. A., Faulenbach, M., Donath, M. Y.

“…Islets of patients with type 2 diabetes have the feature of an inflammatory process reflected by the presence of cytokines, immune cells, β‐cell apoptosis,…”
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TNF-alpha -308G>A polymorphism modulates cytokine serum concentrations and macrovascular complications in diabetic patients on aspirin by Krayenbuehl, P-A, Wiesli, P, Schmid, M, Schmid, C, Ehses, J A, Hersberger, M, Vetter, W, Schulthess, G

“…Tumor necrosis factor (TNF)-alpha has pleiotropic effects in cytokine-mediated inflammation underlying atherogenesis. Activation of this inflammatory process…”
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292 EFFECTS OF GLUCOSE-DEPENDENT INSULINOTROPIC POLYPEPTIDE ON THE PHOSPHORYLATION OF PROTEIN KINASE B (PKB/AKT) AND ITS CONTRIBUTION TO PANCREATIC BETA-CELL SURVIVAL by Winter, K. D., Ehses, J. A., Eeson, G., Kim, S.-J., Nian, C., Warnock, G., Pederson, R. A., McIntosh, C. H.S.

“…The incretin hormone glucose-dependent insulinotropic polypeptide (GIP) is a major regulator of postprandial insulin secretion in mammals. Recent studies have…”
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3 EFFECTS OF GLUCOSE-DEPENDENT INSULINOTROPIC POLYPEPTIDE ON THE PHOSPHORYLATION OF PROTEIN KINASE B (PKB/AKT) AND ITS CONTRIBUTION TO PANCREATIC BETA-CELL SURVIVAL by Winter, K. D., Ehses, J. A., Eeson, G., Kim, S.-J., Nian, C., Warnock, G., Pederson, R. A., McIntosh, C. H.S.

“…The incretin hormone glucose-dependent insulinotropic polypeptide (GIP) is a major regulator of postprandial insulin secretion in mammals. Recent studies have…”
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Interleukin-1–Receptor Antagonist in Type 2 Diabetes Mellitus by Larsen, Claus M, Faulenbach, Mirjam, Vaag, Allan, Vølund, Aage, Ehses, Jan A, Seifert, Burkhardt, Mandrup-Poulsen, Thomas, Donath, Marc Y

“…The expression of interleukin-1–receptor antagonist is reduced in pancreatic islets in type 2 diabetes, and high glucose concentrations induce interleukin-1β…”
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Sustained Effects of Interleukin-1 Receptor Antagonist Treatment in Type 2 Diabetes by Larsen, Claus M, Faulenbach, Mirjam, Vaag, Allan, Ehses, Jan A, Donath, Marc Y, Mandrup-Poulsen, Thomas

“…OBJECTIVE: Interleukin (IL)-1 impairs insulin secretion and induces β-cell apoptosis. Pancreatic β-cell IL-1 expression is increased and interleukin-1 receptor…”
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Mechanisms of β-Cell Death in Type 2 Diabetes by DONATH, Marc Y, EHSES, Jan A, MAEDLER, Kathrin, SCHUMANN, Desiree M, ELLINGSGAARD, Helga, EPPLER, Elisabeth, REINECKE, Manfred

“…A decrease in the number of functional insulin-producing beta-cells contributes to the pathophysiology of type 2 diabetes. Opinions diverge regarding the…”
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A new pathway for glucose-dependent insulinotropic polypeptide (GIP) receptor signaling: evidence for the involvement of phospholipase A2 in GIP-stimulated insulin secretion by Ehses, J A, Lee, S S, Pederson, R A, McIntosh, C H

“…The hormone glucose-dependent insulinotropic polypeptide (GIP) is an important regulator of insulin secretion. GIP has been shown to increase adenylyl cyclase…”
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Leptin Modulates β Cell Expression of IL-1 Receptor Antagonist and Release of IL-1β in Human Islets by Maedler, Kathrin, Sergeev, Pavel, Ehses, Jan A., Mathe, Zoltan, Bosco, Domenico, Berney, Thierry, Dayer, Jean-Michel, Reinecke, Manfred, Halban, Philippe A., Donath, Marc Y., Unger, Roger H.

“…High concentrations of glucose induce β cell production of IL-1β, leading to impaired β cell function and apoptosis in human pancreatic islets. IL-1 receptor…”
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Dipeptidyl Peptidase IV Inhibitor Treatment Stimulates β-Cell Survival and Islet Neogenesis in Streptozotocin-Induced Diabetic Rats by POSPISILIK, J. Andrew, MARTIN, Jennifer, DOTY, Timothy, EHSES, Jan A, PAMIR, Nathalie, LYNN, Francis C, PITEAU, Shalea, DEMUTH, Hans-Ulrich, MCINTOSH, Christopher H. S, PEDERSON, Raymond A

“…Dipeptidyl Peptidase IV Inhibitor Treatment Stimulates β-Cell Survival and Islet Neogenesis in Streptozotocin-Induced Diabetic Rats J. Andrew Pospisilik 1 ,…”
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Macrophages, cytokines and beta-cell death in Type 2 diabetes by Ehses, Jan A, Böni-Schnetzler, Marianne, Faulenbach, Mirjam, Donath, Marc Y

“…The pathology of islets from patients with Type 2 diabetes displays an inflammatory process characterized by the presence of immune cell infiltration,…”
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Glucose-Dependent Insulinotropic Polypeptide Promotes β-(INS-1) Cell Survival via Cyclic Adenosine Monophosphate-Mediated Caspase-3 Inhibition and Regulation of p38 Mitogen-Activated Protein Kinase by Ehses, Jan A, Casilla, Vanbric R, Doty, Tim, Pospisilik, J. Andrew, Winter, Kyle D, Demuth, Hans-Ulrich, Pederson, Raymond A, McIntosh, Christopher H. S

“…The incretin glucose-dependent insulinotropic polypeptide (GIP) is a major regulator of postprandial insulin secretion in mammals. Recent studies in our…”
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Glucose-dependent Insulinotropic Polypeptide Activates the Raf-Mek1/2-ERK1/2 Module via a Cyclic AMP/cAMP-dependent Protein Kinase/Rap1-mediated Pathway by Ehses, Jan A., Pelech, Steven L., Pederson, Raymond A., McIntosh, Christopher H.S.

“…The gastrointestinal hormone, glucose-dependent insulinotropic polypeptide (GIP), is one of the most important regulators of insulin secretion following…”
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EFFECTS OF GLUCOSE-DEPENDENT INSULINOTROPIC POLYPEPTIDE ON THE PHOSPHORYLATION OF PROTEIN KINASE B (PKB/AKT) AND ITS CONTRIBUTION TO PANCREATIC BETA-CELL SURVIVAL: 292 by Winter, K. D., Ehses, J. A., Eeson, G., Kim, S.-J., Nian, C., Warnock, G., Pederson, R. A., McIntosh, C. H.S.

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EFFECTS OF GLUCOSE-DEPENDENT INSULINOTROPIC POLYPEPTIDE ON THE PHOSPHORYLATION OF PROTEIN KINASE B (PKB/AKT) AND ITS CONTRIBUTION TO PANCREATIC BETA-CELL SURVIVAL: 3 by Winter, K. D., Ehses, J. A., Eeson, G., Kim, S.-J., Nian, C., Warnock, G., Pederson, R. A., McIntosh, C. H.S.

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A novel pathway for regulation of glucose‐dependent insulinotropic polypeptide receptor expression in β‐cells by Lynn, Francis C., Thompson, Stephen A., Pospisilik, J. Andrew, Ehses, Jan A., Hinke, Simon A., Pamir, Nathalie, McIntosh, Christopher H. S., Pederson, Raymond A.

“…ABSTRACT Glucose‐dependent insulinotropic polypeptide (GIP) is secreted postprandially and acts in concert with glucose to stimulate insulin secretion from the…”
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Dipeptidyl peptidase IV inhibition in animal models of diabetes by Pospisilik, J Andrew, Ehses, Jan A, Doty, Timothy, McIntosh, Christopher H S, Demuth, Hans-Ulrich, Pederson, Raymond A

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