Search Results - "Ehrlich, Hartmut"

The Anti-Hiv Candidate Abx464 Dampens Intestinal Inflammation by Triggering Il-22 Production in Activated Macrophages by Chebli, Karim, Papon, Laura, Paul, Conception, Garcel, Aude, Campos, Noëlie, Scherrer, Didier, J. Ehrlich, Hartmut, Hahne, Michael, Tazi, Jamal

“…The progression of human immunodeficiency virus (HIV) is associated with mucosal damage in the gastrointestinal (GI) tract. This damage enables bacterial…”
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Demonstration of the Antitumor Activity of the iNKT Agonist ABX196, a Novel Enhancer of Cancer Immunotherapy, in Melanoma and Hepatocarcinoma Mouse Models by Scherrer, Didier, Barrett, Noel, Teyton, Luc, Pearce, Tillman, Nitcheu, Josianne, Pouletty, Philippe, Santo, Julien, Ehrlich, Hartmut J

“…Immune checkpoint blockers (ICB) provide a promising approach to antitumor immunotherapy through blockade of immunosuppressive pathways. The synthetic…”
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S1095 Obefazimod in Patients With Moderate-to-Severe Ulcerative Colitis: Efficacy and Safety Analysis From the 96-Week Open-Label Maintenance Phase 2b Study by Vermeire, Séverine, Nitcheu, Josianne, Gineste, Paul, Sloan, Sheldon, Ehrlich, Hartmut J., Sands, Bruce E.

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Both anti-inflammatory and antiviral properties of novel drug candidate ABX464 are mediated by modulation of RNA splicing by Vautrin, Audrey, Manchon, Laurent, Garcel, Aude, Campos, Noëlie, Lapasset, Laure, Laaref, Abdelhamid Mahdi, Bruno, Roman, Gislard, Marie, Dubois, Emeric, Scherrer, Didier, Ehrlich, J Hartmut, Tazi, Jamal

“…ABX464 is a first-in-class, clinical-stage, small molecule for oral administration that has shown strong anti-inflammatory effects in the DSS-model for…”
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S1096 Long-Term Upregulation of miR-124 in Blood and Rectal Biopsies of Patients With Moderate-to-Severe Ulcerative Colitis Receiving Obefazimod 50mg Daily for 96 Weeks by Santo, Julien, Flatres, Aurélien, Gineste, Paul, Scherrer, Didier, Nitcheu, Josianne, Sloan, Sheldon, Ehrlich, Hartmut J., Sands, Bruce E., Vermeire, Séverine

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S1097 Correlation of miR-124 Upregulation and PK Parameters in Blood of Patients With Moderate-to-Severe Ulcerative Colitis Receiving Obefazimod for 16 Weeks by Santo, Julien, Flatres, Aurélien, Gineste, Paul, Scherrer, Didier, Nitcheu, Josianne, Sloan, Sheldon, Ehrlich, Hartmut J., Sands, Bruce E., Vermeire, Séverine

“…The correlation between miR-124 upregulation and Cmax and AUC was tested with Spearman's non-parametric correlation analysis. The lack of significant PKPD…”
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close look at human IgG sialylation and subclass distribution after lectin fractionation by Stadlmann, Johannes, Weber, Alfred, Pabst, Martin, Anderle, Heinz, Kunert, Renate, Ehrlich, Hartmut J, Peter Schwarz, Hans, Altmann, Friedrich

“…Polyspecific human IgG preparations are indicated for the treatment of primary immunodeficiency disorders associated with defects in humoral immunity. In…”
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Efficacy, safety, and immunogenicity of a Vero-cell-culture-derived trivalent influenza vaccine: a multicentre, double-blind, randomised, placebo-controlled trial by Barrett, P Noel, Dr, Berezuk, Gregory, MS, Fritsch, Sandor, PhD, Aichinger, Gerald, MD, Hart, Mary Kate, PhD, El-Amin, Wael, MD, Kistner, Otfried, PhD, Ehrlich, Hartmut J, MD

“…Summary Background The use of cell-culture technologies for the manufacture of influenza vaccines might contribute to improved strain selection and robust…”
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A Clinical Trial of a Whole-Virus H5N1 Vaccine Derived from Cell Culture by Ehrlich, Hartmut J, Müller, Markus, Oh, Helen M.L, Tambyah, Paul A, Joukhadar, Christian, Montomoli, Emanuele, Fisher, Dale, Berezuk, Greg, Fritsch, Sandor, Löw-Baselli, Alexandra, Vartian, Nina, Bobrovsky, Roman, Pavlova, Borislava G, Pöllabauer, Eva Maria, Kistner, Otfried, Barrett, P. Noel

“…There is a need for a vaccine against avian influenza (H5N1). In this initial study, the administration of two doses of a whole-virus H5N1 vaccine derived from…”
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Safety and immunogenicity of a novel multivalent OspA vaccine against Lyme borreliosis in healthy adults: a double-blind, randomised, dose-escalation phase 1/2 trial by Wressnigg, Nina, PhD, Pöllabauer, Eva-Maria, MD, Aichinger, Gerald, MD, Portsmouth, Daniel, PhD, Löw-Baselli, Alexandra, PhD, Fritsch, Sandor, PhD, Livey, Ian, PhD, Crowe, Brian A, PhD, Schwendinger, Michael, PhD, Brühl, Peter, PhD, Pilz, Andreas, PhD, Dvorak, Thomas, PhD, Singer, Julia, PhD, Firth, Clair, MSc, Luft, Benjamin, Prof, Schmitt, Bernhard, MD, Zeitlinger, Markus, MD, Müller, Markus, Prof, Kollaritsch, Herwig, Prof, Paulke-Korinek, Maria, MD, Esen, Meral, MD, Kremsner, Peter G, Prof, Ehrlich, Hartmut J, MD, Barrett, P Noel, Dr

“…Summary Background Lyme borreliosis is caused by Borrelia burgdorferi sensu stricto in the USA and by several Borrelia species in Europe and Asia, but no human…”
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ABX464 (obefazimod) for patients with COVID-19 at risk for severe disease: miR-AGE, a randomized, double-blind placebo-controlled trial by Giavina-Bianchi, Pedro, Cua, Eric, Risso, Karine, Mondain, Véronique, Vissian, Anaïs, Joie, Cécile, Pouletty, Philippe, Gineste, Paul, Ehrlich, Hartmut J., Kalil, Jorge

“…BackgroundABX464 (obefazimod) is a small molecule that upregulates a single microRNA (miR-124) in immune cells and reduces the production of various…”
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A Tick-borne Encephalitis Virus Vaccine Based on the European Prototype Strain Induces Broadly Reactive Cross-neutralizing Antibodies in Humans by Orlinger, Klaus K., Hofmeister, Yvonne, Fritz, Richard, Holzer, Georg W., Falkner, Falko G., Unger, Bernd, Loew-Baselli, Alexandra, Poellabauer, Eva-Maria, Ehrlich, Hartmut J., Barrett, P. Noel, Kreil, Thomas R.

“…After vaccination of humans with tick-borne encephalitis virus (TBEV) vaccine, the extent of crossneutralization between viruses of the European, Far Eastern,…”
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Human anti-macrophage migration inhibitory factor antibodies inhibit growth of human prostate cancer cells in vitro and in vivo by Hussain, Filza, Freissmuth, Michael, Völkel, Dirk, Thiele, Michael, Douillard, Patrice, Antoine, Gerhard, Thurner, Patrick, Ehrlich, Hartmut, Schwarz, Hans-Peter, Scheiflinger, Friedrich, Kerschbaumer, Randolf J

“…Macrophage migration inhibitory factor (MIF) is a proinflammatory cytokine, originally discovered for its eponymous effect and now known for pleiotropic…”
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Vectors based on modified vaccinia Ankara expressing influenza H5N1 hemagglutinin induce substantial cross-clade protective immunity by Hessel, Annett, Schwendinger, Michael, Holzer, Georg W, Orlinger, Klaus K, Coulibaly, Sogue, Savidis-Dacho, Helga, Zips, Marie-Luise, Crowe, Brian A, Kreil, Thomas R, Ehrlich, Hartmut J, Barrett, P Noel, Falkner, Falko G

“…New highly pathogenic H5N1 influenza viruses are continuing to evolve with a potential threat for an influenza pandemic. So far, the H5N1 influenza viruses…”
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Pharmacokinetics and tolerability of ABX464, a novel first-in-class compound to treat HIV infection, in healthy HIV-uninfected subjects by Scherrer, Didier, Rouzier, Regine, Noel Barrett, P, Steens, Jean-Marc, Gineste, Paul, Murphy, Robert L, Tazi, Jamal, Ehrlich, Hartmut J

“…An anti-HIV compound (ABX464) has been developed with a novel mechanism of activity in that it blocks viral gene expression in cells that are already infected…”
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A whole virus pandemic influenza H1N1 vaccine is highly immunogenic and protective in active immunization and passive protection mouse models by Kistner, Otfried, Crowe, Brian A, Wodal, Walter, Kerschbaum, Astrid, Savidis-Dacho, Helga, Sabarth, Nicolas, Falkner, Falko G, Mayerhofer, Ines, Mundt, Wolfgang, Reiter, Manfred, Grillberger, Leopold, Tauer, Christa, Graninger, Michael, Sachslehner, Alois, Schwendinger, Michael, Brühl, Peter, Kreil, Thomas R, Ehrlich, Hartmut J, Barrett, P Noel

“…The recent emergence and rapid spread of a novel swine-derived H1N1 influenza virus has resulted in the first influenza pandemic of this century. Monovalent…”
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Randomized Trial of Food Effect on Pharmacokinetic Parameters of ABX464 Administered Orally to Healthy Male Subjects by Scherrer, Didier, Rouzier, Regine, Cardona, Marine, Barrett, P Noel, Steens, Jean-Marc, Gineste, Paul, Murphy, Robert L, Tazi, Jamal, Ehrlich, Hartmut J

“…ABX464 is an antiviral that provides a novel approach to the reduction and control of HIV infection. Investigation of food influence is important in the…”
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The influence of carrier protein on the immunogenicity of simultaneously administered conjugate vaccines in infants by Pöllabauer, Eva Maria, Petermann, Robert, Ehrlich, Hartmut J

“…Abstract Continuing additions of new vaccines to routine infant vaccination schedules have prompted concerns about potential interactions between vaccine…”
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Vero cell culture-derived pandemic influenza vaccines: preclinical and clinical development by Barrett, P Noel, Portsmouth, Daniel, Ehrlich, Hartmut J

“…Several subtypes of influenza A viruses with pandemic potential are endemic in bird populations throughout Asia, Africa and the Middle East, and evidence…”
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A Vero Cell-Derived Whole-Virus H5N1 Vaccine Effectively Induces Neuraminidase-Inhibiting Antibodies by Fritz, Richard, Sabarth, Nicolas, Kiermayr, Stefan, Hohenadl, Christine, Howard, M. Keith, Ilk, Reinhard, Kistner, Otfried, Ehrlich, Hartmut J., Barrett, P. Noel, Kreil, Thomas R.

“…A Vero cell-derived whole-virus H5N1 influenza vaccine has been shown to induce neutralizing antibodies directed against the hemagglutinin (HA) protein of…”
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