Search Results - "Ehnman, M"

The uPA uPAR system regulates the bioavailability of PDGF-DD: implications for tumour growth by Ehnman, M, Li, H, Fredriksson, L, Pietras, K, Eriksson, U

“…Members of the platelet-derived growth factor (PDGF) family are mitogens for cells of mesenchymal origin and have important functions during embryonic…”
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PDGF receptors in tumor biology: prognostic and predictive potential by Paulsson, Janna, Ehnman, Monika, Östman, Arne

“…PDGF receptors (PDGFRs) exert cell type-specific effects in many different tumor types. They are emerging as key regulators of mesenchymal cells of the tumor…”
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The Tumor Microenvironment of Pediatric Sarcoma: Mesenchymal Mechanisms Regulating Cell Migration and Metastasis by Ehnman, Monika, Chaabane, Wiem, Haglund, Felix, Tsagkozis, Panagiotis

“…Purpose of Review This review presents a selection of regulatory molecules of tumor microenvironmental properties and metastasis. Signaling pathways…”
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Therapeutic targeting of platelet-derived growth factor receptors in solid tumors by Ehnman, Monika, Östman, Arne

“…Genetic aberrations that are associated with platelet-derived growth factor receptor (PDGFR) activity are frequently found in glioblastomas (10 - 15%),…”
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An immunosuppressive macrophage profile attenuates the prognostic impact of CD20-positive B cells in human soft tissue sarcoma by Tsagozis, Panagiotis, Augsten, Martin, Zhang, Yifan, Li, Tian, Hesla, Asle, Bergh, Jonas, Haglund, Felix, Tobin, Nicholas P., Ehnman, Monika

“…Background Immune cells can regulate disease progression and response to treatment in multiple tumor types, but their activities in human soft tissue sarcoma…”
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Mice Lacking Platelet-Derived Growth Factor D Display a Mild Vascular Phenotype by Gladh, Hanna, Folestad, Erika Bergsten, Muhl, Lars, Ehnman, Monika, Tannenberg, Philip, Lawrence, Anna-Lisa, Betsholtz, Christer, Eriksson, Ulf

“…Platelet-derived growth factor D (PDGF-D) is the most recently discovered member of the PDGF family. PDGF-D signals through PDGF receptor β, but its biological…”
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Distinct Effects of Ligand-Induced PDGFRα and PDGFRβ Signaling in the Human Rhabdomyosarcoma Tumor Cell and Stroma Cell Compartments by EHNMAN, Monika, MISSIAGLIA, Edoardo, ERIKSSON, Ulf, FOLESTAD, Erika, SELFE, Joanna, STRELL, Carina, THWAY, Khin, BRODIN, Bertha, PIETRAS, Kristian, SHIPLEY, Janet, ÖSTMAN, Arne

“…Platelet-derived growth factor receptors (PDGFR) α and β have been suggested as potential targets for treatment of rhabdomyosarcoma, the most common soft…”
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Telomerase promoter mutations and copy number alterations in solitary fibrous tumours by Lin, Yingbo, Seger, Nelly, Tsagkozis, Panagiotis, Hesla, Asle C, Ghaderi, Mehran, Chen, Yi, Ehnman, Monika, Warsito, Dudi, Wejde, Johan, Larsson, Olle, Haglund, Felix

“…Solitary fibrous tumour (SFT) is an infrequently metastasising mesenchymal tumour defined by the fusion gene. Activating mutations in the ( ) gene promoter has…”
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Microenvironmental Targets in Sarcoma by Ehnman, Monika, Larsson, Olle

“…Sarcomas are rare malignant tumors affecting all age groups. They are typically classified according to their resemblance to corresponding normal tissue. Their…”
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IGFBP5 is induced by tumor-suppressive naive stromal cells and regulates GAS2-associated apoptosis in rhabdomyosarcoma by Ehnman, M, Katkhada, K, Meng, LZ, Zhang, Y, Zhao, BB, Tong, SL, Kallai, A, Ostman, A, Tobin, N

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Mechanical Confinement and DDR1 Signaling Synergize to Regulate Collagen‐Induced Apoptosis in Rhabdomyosarcoma Cells by Gonzalez‐Molina, Jordi, Kirchhof, Katharina Miria, Rathod, Bhavik, Moyano‐Galceran, Lidia, Calvo‐Noriega, Maria, Kokaraki, Georgia, Bjørkøy, Astrid, Ehnman, Monika, Carlson, Joseph W., Lehti, Kaisa

“…Fibrillar collagens promote cell proliferation, migration, and survival in various epithelial cancers and are generally associated with tumor aggressiveness…”
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Molecular Profiling Defines Three Subtypes of Synovial Sarcoma by Chen, Yi, Su, Yanhong, Cao, Xiaofang, Siavelis, Ioannis, Leo, Isabelle Rose, Zeng, Jianming, Tsagkozis, Panagiotis, Hesla, Asle C., Papakonstantinou, Andri, Liu, Xiao, Huang, Wen‐Kuan, Zhao, Binbin, Haglund, Cecilia, Ehnman, Monika, Johansson, Henrik, Lin, Yingbo, Lehtiö, Janne, Zhang, Yifan, Larsson, Olle, Li, Xuexin, de Flon, Felix Haglund

“…Synovial Sarcomas (SS) are characterized by the presence of the SS18::SSX fusion gene, which protein product induce chromatin changes through remodeling of the…”
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Cancer/testis antigen expression in human mesenchymal stem cells : Down-regulation of SSX impairs cell migration and matrix metalloproteinase 2 expression by CRONWRIGHT, Garth, LE BLANC, Katarina, GÖTHERSTRÖM, Cecilia, DARCY, Padraig, EHNMAN, Monika, BRODIN, Bertha

“…Several families of genes by and large located on the X chromosome encode proteins of unspecified function. Commonly known as cancer/testis (CT) antigens, they…”
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CD11c-CD8 Spatial Cross Presentation: A Novel Approach to Link Immune Surveillance and Patient Survival in Soft Tissue Sarcoma by Su, Yanhong, Tsagkozis, Panagiotis, Papakonstantinou, Andri, Tobin, Nicholas P, Gultekin, Okan, Malmerfelt, Anna, Ingelshed, Katrine, Neo, Shi Yong, Lundquist, Johanna, Chaabane, Wiem, Nisancioglu, Maya H, Leiss, Lina W, Östman, Arne, Bergh, Jonas, Sedimbi, Saikiran, Lehti, Kaisa, Lundqvist, Andreas, Stragliotto, Christina L, Haglund, Felix, Ehnman, Monika

“…Checkpoint inhibitors are slowly being introduced in the care of specific sarcoma subtypes such as undifferentiated pleomorphic sarcoma, alveolar soft part…”
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Structural Requirements for Activation of Latent Platelet-derived Growth Factor CC by Tissue Plasminogen Activator by Fredriksson, Linda, Ehnman, Monika, Fieber, Christina, Eriksson, Ulf

“…Platelet-derived growth factor C (PDGF-C) is one of four members in the PDGF family of growth factors, which are known mitogens and survival factors for cells…”
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