Search Results - "Ehninger, Dan"

From genes to cognition in tuberous sclerosis: Implications for mTOR inhibitor-based treatment approaches by Ehninger, Dan

“…Tuberous sclerosis (TSC) is a neurocutaneous disorder with an autosomal-dominant pattern of inheritance and is caused by heterozygous mutations in the TSC1 or…”
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Rapamycin for treating Tuberous sclerosis and Autism spectrum disorders by Ehninger, Dan, Silva, Alcino J

“…Tuberous sclerosis (TSC) is a genetic disorder caused by heterozygous mutations in the TSC1 or TSC2 genes and is associated with autism spectrum disorders…”
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AIFM1 beyond cell death: An overview of this OXPHOS-inducing factor in mitochondrial diseases by Wischhof, Lena, Scifo, Enzo, Ehninger, Dan, Bano, Daniele

“…Apoptosis-inducing factor (AIF) is a mitochondrial intermembrane space flavoprotein with diverse functions in cellular physiology. In this regard, a large…”
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Reversal of learning deficits in a Tsc2 +/− mouse model of tuberous sclerosis by Silva, Alcino J, Ehninger, Dan, Han, Sangyeul, Shilyansky, Carrie, Zhou, Yu, Li, Weidong, Kwiatkowski, David J, Ramesh, Vijaya

“…Tuberous sclerosis is a single-gene disorder caused by heterozygous mutations in the TSC1 (9q34) or TSC2 (16p13.3) gene and is frequently associated with…”
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Decoding metabolic signatures in Alzheimer’s disease: a mitochondrial perspective by Bano, Daniele, Ehninger, Dan, Bagetta, Giacinto

“…Alzheimer’s disease (AD) is one of the most prevalent age-related neurodegenerative diseases and accounts for the majority of dementia cases worldwide…”
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Mitochondrial complex I inhibition enhances astrocyte responsiveness to pro-inflammatory stimuli by Wischhof, Lena, Mathew, Amal John, Bonaguro, Lorenzo, Beyer, Marc, Ehninger, Dan, Nicotera, Pierluigi, Bano, Daniele

“…Inhibition of the mitochondrial oxidative phosphorylation (OXPHOS) system can lead to metabolic disorders and neurodegenerative diseases. In primary…”
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Physical exercise prevents age-related decline in precursor cell activity in the mouse dentate gyrus by Kronenberg, Golo, Bick-Sander, Anika, Bunk, Eva, Wolf, Claudia, Ehninger, Dan, Kempermann, Gerd

“…Physical activity induces adult hippocampal neurogenesis. We here show that the acute up-regulating effect of voluntary wheel running on precursor cell…”
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Memory trace interference impairs recall in a mouse model of Alzheimer’s disease by Poll, Stefanie, Mittag, Manuel, Musacchio, Fabrizio, Justus, Lena C., Giovannetti, Eleonora Ambrad, Steffen, Julia, Wagner, Jens, Zohren, Lioba, Schoch, Susanne, Schmidt, Boris, Jackson, Walker S., Ehninger, Dan, Fuhrmann, Martin

“…In Alzheimer’s disease (AD), hippocampus-dependent memories underlie an extensive decline. The neuronal ensemble encoding a memory, termed engram, is partially…”
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Epigenetic alterations in longevity regulators, reduced life span, and exacerbated aging-related pathology in old father offspring mice by Xie, Kan, Ryan, Devon P., Pearson, Brandon L., Henzel, Kristin S., Neff, Frauke, Vidal, Ramon O., Hennion, Magali, Lehmann, Isabelle, Schleif, Melvin, Schröder, Susanne, Adler, Thure, Rathkolb, Birgit, Rozman, Jan, Schütz, Anna-Lena, Prehn, Cornelia, Mickael, Michel E., Weiergräber, Marco, Adamski, Jerzy, Busch, Dirk H., Ehninger, Gerhard, Matynia, Anna, Jackson, Walker S., Wolf, Eckhard, Fuchs, Helmut, Gailus-Durner, Valerie, Bonn, Stefan, de Angelis, Martin Hrabě, Ehninger, Dan

“…Advanced age is not only a major risk factor for a range of disorders within an aging individual but may also enhance susceptibility for disease in the next…”
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SGPL1 (sphingosine phosphate lyase 1) modulates neuronal autophagy via phosphatidylethanolamine production by Mitroi, Daniel N., Karunakaran, Indulekha, Gräler, Markus, Saba, Julie D., Ehninger, Dan, Ledesma, María Dolores, van Echten-Deckert, Gerhild

“…Macroautophagy/autophagy defects have been identified as critical factors underlying the pathogenesis of neurodegenerative diseases. The roles of the bioactive…”
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Sex- and region-specific cortical and hippocampal whole genome transcriptome profiles from control and APP/PS1 Alzheimer's disease mice by Papazoglou, Anna, Henseler, Christina, Weickhardt, Sandra, Teipelke, Jenni, Papazoglou, Panagiota, Daubner, Johanna, Schiffer, Teresa, Krings, Damian, Broich, Karl, Hescheler, Jürgen, Sachinidis, Agapios, Ehninger, Dan, Scholl, Catharina, Haenisch, Britta, Weiergräber, Marco

“…A variety of Alzheimer's disease (AD) mouse models has been established and characterized within the last decades. To get an integrative view of the…”
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Mechanism and treatment for learning and memory deficits in mouse models of Noonan syndrome by Lee, Yong-Seok, Ehninger, Dan, Zhou, Miou, Oh, Jun-Young, Kang, Minkyung, Kwak, Chuljung, Ryu, Hyun-Hee, Butz, Delana, Araki, Toshiyuki, Cai, Ying, Balaji, J, Sano, Yoshitake, Nam, Christine I, Kim, Hyong Kyu, Kaang, Bong-Kiun, Burger, Corinna, Neel, Benjamin G, Silva, Alcino J

“…Noonan syndrome (NS) is an autosomal dominant genetic disease that is co-morbid with cognitive deficits in a subset of patients. Using mouse models of NS, a…”
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Additive effects of physical exercise and environmental enrichment on adult hippocampal neurogenesis in mice by Fabel, Klaus, Wolf, Susanne A, Ehninger, Dan, Babu, Harish, Leal-Galicia, Perla, Kempermann, Gerd

“…Voluntary physical exercise (wheel running, RUN) and environmental enrichment both stimulate adult hippocampal neurogenesis but do so by different mechanisms…”
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Variability of doublecortin-associated dendrite maturation in adult hippocampal neurogenesis is independent of the regulation of precursor cell proliferation by Plümpe, Tobias, Ehninger, Dan, Steiner, Barbara, Klempin, Friederike, Jessberger, Sebastian, Brandt, Moritz, Römer, Benedikt, Rodriguez, Gerardo Ramirez, Kronenberg, Golo, Kempermann, Gerd

“…In the course of adult hippocampal neurogenesis most regulation takes place during the phase of doublecortin (DCX) expression, either as pro-proliferative…”
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The anti-diabetic drug metformin reduces BACE1 protein level by interfering with the MID1 complex by Hettich, Moritz M, Matthes, Frank, Ryan, Devon P, Griesche, Nadine, Schröder, Susanne, Dorn, Stephanie, Krauβ, Sybille, Ehninger, Dan

“…Alzheimer's disease (AD), the most common form of dementia in the elderly, is characterized by two neuropathological hallmarks: senile plaques, which are…”
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Enriched environment and physical activity reduce microglia and influence the fate of NG2 cells in the amygdala of adult mice by Ehninger, Dan, Wang, Li-Ping, Klempin, Friederike, Römer, Benedikt, Kettenmann, Helmut, Kempermann, Gerd

“…Proliferative cells expressing proteoglycan neuron-glia 2 (NG2) are considered to represent parenchymal precursor cells in the adult brain and are thought to…”
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Why and how physical activity promotes experience-induced brain plasticity by Kempermann, Gerd, Fabel, Klaus, Ehninger, Dan, Babu, Harish, Leal-Galicia, Perla, Garthe, Alexander, Wolf, Susanne A

“…Adult hippocampal neurogenesis is an unusual case of brain plasticity, since new neurons (and not just neurites and synapses) are added to the network in an…”
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A Novel Rat Infant Model of Medial Temporal Lobe Epilepsy Reveals New Insight into the Molecular Biology and Epileptogenesis in the Developing Brain by Wormuth, Carola, Papazoglou, Anna, Henseler, Christina, Ehninger, Dan, Broich, Karl, Haenisch, Britta, Hescheler, Jürgen, Köhling, Rüdiger, Weiergräber, Marco

“…Although several adult rat models of medial temporal lobe epilepsy (mTLE) have been described in detail, our knowledge of mTLE epileptogenesis in infant rats…”
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Pharmacological Neuroenhancement: Current Aspects of Categorization, Epidemiology, Pharmacology, Drug Development, Ethics, and Future Perspectives by Daubner, Johanna, Arshaad, Muhammad Imran, Henseler, Christina, Hescheler, Jürgen, Ehninger, Dan, Broich, Karl, Rawashdeh, Oliver, Papazoglou, Anna, Weiergräber, Marco

“…Recent pharmacoepidemiologic studies suggest that pharmacological neuroenhancement (pNE) and mood enhancement are globally expanding phenomena with distinctly…”
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Sex-specific cortical, hippocampal and thalamic whole genome transcriptome data from controls and a G72 schizophrenia mouse model by Papazoglou, Anna, Henseler, Christina, Weickhardt, Sandra, Daubner, Johanna, Schiffer, Teresa, Broich, Karl, Hescheler, Jürgen, Sachinidis, Agapios, Ehninger, Dan, Haenisch, Britta, Weiergräber, Marco

“…The G72 mouse model of schizophrenia represents a well-known model that was generated to meet the main translational criteria of isomorphism, homology and…”
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