Marked Increase in Child Survival after Four Years of Intensive Malaria Control

In malaria-endemic countries in Africa, a large proportion of child deaths are directly or indirectly attributable to infection with Plasmodium falciparum. Four years after high coverage, multiple malaria control interventions were introduced on Bioko Island, Equatorial Guinea, changes in infection...

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Bibliographic Details
Published in:	The American journal of tropical medicine and hygiene Vol. 80; no. 6; pp. 882 - 888
Main Authors:	Kleinschmidt, Immo, Schwabe, Christopher, Benavente, Luis, Torrez, Miguel, Ridl, Frances C, Segura, Jose Luis, Ehmer, Paul, Nchama, Gloria Nseng
Format:	Journal Article
Language:	English
Published:	Deerfield, IL ASTMH 01-06-2009 American Society of Tropical Medecine and Hygiene
Subjects:	Adolescent Adult Anemia - epidemiology Anemia - parasitology Anemia - prevention & control Antimalarials - therapeutic use Bedding and Linens Biological and medical sciences Child Child, Preschool Equatorial Guinea - epidemiology Female Human protozoal diseases Humans Industry - economics Infectious diseases Insecticides Malaria Malaria, Falciparum - drug therapy Malaria, Falciparum - mortality Malaria, Falciparum - prevention & control Medical sciences Mosquito Control - economics Mosquito Control - methods Parasitic diseases Petroleum - economics Plasmodium falciparum Pregnancy Protozoal diseases Young Adult Equatorial Guinea Equatorial Guinea, Bioko I Human Infection Prevention Protozoal disease Prognosis Malaria Check Tropical medicine Parasitosis Child Survival
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Summary:	In malaria-endemic countries in Africa, a large proportion of child deaths are directly or indirectly attributable to infection with Plasmodium falciparum. Four years after high coverage, multiple malaria control interventions were introduced on Bioko Island, Equatorial Guinea, changes in infection with malarial parasites, anemia, and fever history in children were estimated and assessed in relation to changes in all-cause under-5 mortality. There were reductions in prevalence of infection (odds ratio [OR] = 0.31, 95% confidence interval [CI] = 0.2-0.46), anemia (OR = 0.11, 95% CI = 0.07-0.18), and reported fevers (OR = 0.41, 95% CI = 0.22-0.76) in children. Under-5 mortality fell from 152 per 1,000 births (95% CI = 122-186) to 55 per 1,000 (95% CI = 38-77; hazard ratio = 0.34 [95% CI = 0.23-0.49]). Effective malaria control measures can dramatically increase child survival and play a key role in achieving millennium development goals.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0002-9637 1476-1645
DOI:	10.4269/ajtmh.2009.80.882