Search Results - "Ehmann, David"

Avibactam is a covalent, reversible, non–β-lactam β-lactamase inhibitor by Ehmann, David E, Jahić, Haris, Ross, Philip L, Gu, Rong-Fang, Hu, Jun, Kern, Gunther, Walkup, Grant K, Fisher, Stewart L

“…Avibactam is a β-lactamase inhibitor that is in clinical development, combined with β-lactam partners, for the treatment of bacterial infections comprising…”
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Novel compounds targeting bacterial DNA topoisomerase/DNA gyrase by Ehmann, David E, Lahiri, Sushmita D

“…Graphical abstract…”
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Kinetics of Avibactam Inhibition against Class A, C, and D β-Lactamases by Ehmann, David E., Jahić, Haris, Ross, Philip L., Gu, Rong-Fang, Hu, Jun, Durand-Réville, Thomas F., Lahiri, Sushmita, Thresher, Jason, Livchak, Stephania, Gao, Ning, Palmer, Tiffany, Walkup, Grant K., Fisher, Stewart L.

“…Avibactam is a non-β-lactam β-lactamase inhibitor with a spectrum of activity that includes β-lactamase enzymes of classes A, C, and selected D examples. In…”
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Molecular mechanisms of sulbactam antibacterial activity and resistance determinants in Acinetobacter baumannii by Penwell, William F, Shapiro, Adam B, Giacobbe, Robert A, Gu, Rong-Fang, Gao, Ning, Thresher, Jason, McLaughlin, Robert E, Huband, Michael D, DeJonge, Boudewijn L M, Ehmann, David E, Miller, Alita A

“…Sulbactam is a class A β-lactamase inhibitor with intrinsic whole-cell activity against certain bacterial species, including Acinetobacter baumannii. The…”
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Untargeted Metabolomics To Ascertain Antibiotic Modes of Action by Vincent, Isabel M, Ehmann, David E, Mills, Scott D, Perros, Manos, Barrett, Michael P

“…Deciphering the mode of action (MOA) of new antibiotics discovered through phenotypic screening is of increasing importance. Metabolomics offers a potentially…”
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Novel heterozygous PRPH2 variant identified in a patient with spinocerebellar ataxia type 14 and macular dystrophy by Chen, Tugche S, Sheri, Narin, Ehmann, David S, Benson, Matthew D

“…To report on a patient with spinocerebellar ataxia type 14 (SCA14) and macular dystrophy with identification of a novel variant. Case report. A 63-year-old…”
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Translating slow-binding inhibition kinetics into cellular and in vivo effects by Walkup, Grant K, You, Zhiping, Ross, Philip L, Allen, Eleanor K H, Daryaee, Fereidoon, Hale, Michael R, O'Donnell, John, Ehmann, David E, Schuck, Virna J A, Buurman, Ed T, Choy, Allison L, Hajec, Laurel, Murphy-Benenato, Kerry, Marone, Valerie, Patey, Sara A, Grosser, Lena A, Johnstone, Michele, Walker, Stephen G, Tonge, Peter J, Fisher, Stewart L

“…Drug-target residence time is viewed as a predictor of the clinical efficacy of small-molecule drugs. A pharmacodynamic model, taking into account the target…”
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Acute macular neuroretinopathy in a case of chronic lymphocytic leukemia by Benson, Matthew D., Ruzicki, Jessica, Ehmann, David S.

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Cataract surgery and age-related macular degeneration by Ehmann, David S, Ho, Allen C

“…PURPOSE OF REVIEWThe following review describes the recent evidence regarding the effect of cataract surgery on age-related macular degeneration (AMD). RECENT…”
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Are the changes in diagnostic criteria for gestational diabetes mellitus reflected in perinatal outcomes? A retrospective assessment by Ehmann, David M. T., Hickman, Peter E., Potter, Julia M.

“…Background Gestational diabetes mellitus (GDM) is glucose intolerance first diagnosed during pregnancy not due to overt diabetes. Recent changes to the…”
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ETX2514 is a broad-spectrum β-lactamase inhibitor for the treatment of drug-resistant Gram-negative bacteria including Acinetobacter baumannii by Durand-Réville, Thomas F., Guler, Satenig, Comita-Prevoir, Janelle, Chen, Brendan, Bifulco, Neil, Huynh, Hoan, Lahiri, Sushmita, Shapiro, Adam B., McLeod, Sarah M., Carter, Nicole M., Moussa, Samir H., Velez-Vega, Camilo, Olivier, Nelson B., McLaughlin, Robert, Gao, Ning, Thresher, Jason, Palmer, Tiffany, Andrews, Beth, Giacobbe, Robert A., Newman, Joseph V., Ehmann, David E., de Jonge, Boudewijn, O'Donnell, John, Mueller, John P., Tommasi, Rubén A., Miller, Alita A.

“…Multidrug-resistant (MDR) bacterial infections are a serious threat to public health. Among the most alarming resistance trends is the rapid rise in the number…”
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PHACOVITRECTOMY FOR PRIMARY RHEGMATOGENOUS RETINAL DETACHMENT REPAIR: A Retrospective Review by Benson, Matthew D., Sia, David, Seamone, Mark E., Greve, Mark, Hinz, Brad, Tennant, Matthew T. S., Baker, Chad, Somani, Rizwan, Ehmann, David S.

“…To analyze the single surgery success rate and anterior segment complications related to phacoemulsification and intraocular lens implantation in a series of…”
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The Impact of Bariatric Surgery on Diabetic Retinopathy: A Systematic Review and Meta-Analysis by Cheung, Douglas, Switzer, Noah J., Ehmann, David, Rudnisky, Christopher, Shi, Xinzhe, Karmali, Shahzeer

“…Background Significant reductions in glucose control immediately post bariatric surgery in patients with longstanding poor glycemic control can lead to the…”
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Pharmacodynamic Profiling of a Siderophore-Conjugated Monocarbam in Pseudomonas aeruginosa: Assessing the Risk for Resistance and Attenuated Efficacy by Kim, Aryun, Kutschke, Amy, Ehmann, David E, Patey, Sara A, Crandon, Jared L, Gorseth, Elise, Miller, Alita A, McLaughlin, Robert E, Blinn, Christina M, Chen, April, Nayar, Asha S, Dangel, Brian, Tsai, Andy S, Rooney, Michael T, Murphy-Benenato, Kerry E, Eakin, Ann E, Nicolau, David P

“…The objective of this study was to investigate the risk of attenuated efficacy due to adaptive resistance for the siderophore-conjugated monocarbam SMC-3176 in…”
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NBTI 5463 Is a Novel Bacterial Type II Topoisomerase Inhibitor with Activity against Gram-Negative Bacteria and In Vivo Efficacy by DOUGHERTY, Thomas J, NAYAR, Asha, NEWMAN, Joseph V, HOPKINS, Sussie, STONE, Gregory G, JOHNSTONE, Michele, SHAPIRO, Adam B, CRONIN, Mark, RECK, Folkert, EHMANN, David E

“…The need for new antibiotics that address serious Gram-negative infections is well recognized. Our efforts with a series of novel bacterial type II…”
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Molecular Basis of Selective Inhibition and Slow Reversibility of Avibactam against Class D Carbapenemases: A Structure-Guided Study of OXA-24 and OXA-48 by Lahiri, Sushmita D, Mangani, Stefano, Jahić, Haris, Benvenuti, Manuela, Durand-Reville, Thomas F, De Luca, Filomena, Ehmann, David E, Rossolini, Gian Maria, Alm, Richard A, Docquier, Jean-Denis

“…The Class D (or OXA-type) β-lactamases have expanded to be the most diverse group of serine β-lactamases with a highly heterogeneous β-lactam hydrolysis…”
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Myostatin and activin blockade by engineered follistatin results in hypertrophy and improves dystrophic pathology in mdx mouse more than myostatin blockade alone by Iskenderian, Andrea, Liu, Nan, Deng, Qingwei, Huang, Yan, Shen, Chuan, Palmieri, Kathleen, Crooker, Robert, Lundberg, Dianna, Kastrapeli, Niksa, Pescatore, Brian, Romashko, Alla, Dumas, John, Comeau, Robert, Norton, Angela, Pan, Jing, Rong, Haojing, Derakhchan, Katayoun, Ehmann, David E

“…Myostatin antagonists are being developed as therapies for Duchenne muscular dystrophy due to their strong hypertrophic effects on skeletal muscle. Engineered…”
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Novel N-Linked Aminopiperidine Inhibitors of Bacterial Topoisomerase Type II with Reduced pK a: Antibacterial Agents with an Improved Safety Profile by Reck, Folkert, Alm, Richard A, Brassil, Patrick, Newman, Joseph V, Ciaccio, Paul, McNulty, John, Barthlow, Herbert, Goteti, Kosalaram, Breen, John, Comita-Prevoir, Janelle, Cronin, Mark, Ehmann, David E, Geng, Bolin, Godfrey, Andrew Aydon, Fisher, Stewart L

“…Novel non-fluoroquinolone inhibitors of bacterial type II topoisomerases (DNA gyrase and topoisomerase IV) are of interest for the development of new…”
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Scleral-Sutured Intraocular Lens Dislocations Secondary to Eyelet Fractures by Watane, Arjun, Botsford, Benjamin W., Sood, Arjun B., Williams, Andrew M., Xu, David, Gupta, R. Rishi, Conner, Ian P., Sivalingam, Arunan, Gupta, Omesh P., Ward, Matthew S., Mehta, Sonia, Cid, Mario del, Crossan, Alessa, Sierpina, David I., Hwang, Frank S., Rachitskaya, Aleksandra, Ehmann, David S., Kovacs, Kyle D., Orlin, Anton, Zhang, Alice Y., Patel, Umangi, Dubovy, Sander, Klufas, Michael A., Patel, Nimesh A., Sridhar, Jayanth, Yannuzzi, Nicolas A.

“…To report clinical features and visual outcomes following eyelet fractures of scleral-sutured enVista MX60 (Bausch + Lomb) intraocular lenses (IOL)…”
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Inhibition of Neisseria gonorrhoeae Type II Topoisomerases by the Novel Spiropyrimidinetrione AZD0914 by Kern, Gunther, Palmer, Tiffany, Ehmann, David E., Shapiro, Adam B., Andrews, Beth, Basarab, Gregory S., Doig, Peter, Fan, Jun, Gao, Ning, Mills, Scott D., Mueller, John, Sriram, Shubha, Thresher, Jason, Walkup, Grant K.

“…We characterized the inhibition of Neisseria gonorrhoeae type II topoisomerases gyrase and topoisomerase IV by AZD0914 (AZD0914 will be henceforth known as…”
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