Search Results - "Ehinger, Yann"

Brain-specific inhibition of mTORC1 eliminates side effects resulting from mTORC1 blockade in the periphery and reduces alcohol intake in mice by Ehinger, Yann, Zhang, Ziyang, Phamluong, Khanhky, Soneja, Drishti, Shokat, Kevan M., Ron, Dorit

“…Alcohol Use Disorder (AUD) affects a large portion of the population. Unfortunately, efficacious medications to treat the disease are limited. Studies in…”
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Severe offtarget effects following intravenous delivery of AAV9-MECP2 in a female mouse model of Rett syndrome by Matagne, Valerie, Borloz, Emilie, Ehinger, Yann, Saidi, Lydia, Villard, Laurent, Roux, Jean-Christophe

“…Rett syndrome (RTT) is a severe X-linked neurodevelopmental disorder that is primarily caused by mutations in the methyl CpG binding protein 2 gene (MECP2)…”
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mTORC1 in the orbitofrontal cortex promotes habitual alcohol seeking by Morisot, Nadege, Phamluong, Khanhky, Ehinger, Yann, Berger, Anthony L, Moffat, Jeffrey J, Ron, Dorit

“…The mechanistic target of rapamycin complex 1 (mTORC1) plays an important role in dendritic translation and in learning and memory. We previously showed that…”
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cAMP-Fyn signaling in the dorsomedial striatum direct pathway drives excessive alcohol use by Ehinger, Yann, Morisot, Nadege, Phamluong, Khanhky, Sakhai, Samuel A, Soneja, Drishti, Adrover, Martin F, Alvarez, Veronica A, Ron, Dorit

“…Fyn kinase in the dorsomedial striatum (DMS) of rodents plays a central role in mechanisms underlying excessive alcohol intake. The DMS is comprised of medium…”
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Correction: mTORC1 in the orbitofrontal cortex promotes habitual alcohol seeking by Morisot, Nadege, Phamluong, Khanhky, Ehinger, Yann, Berger, Anthony L, Moffat, Jeffrey J, Ron, Dorit

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A codon-optimized Mecp2 transgene corrects breathing deficits and improves survival in a mouse model of Rett syndrome by Matagne, Valerie, Ehinger, Yann, Saidi, Lydia, Borges-Correia, Ana, Barkats, Martine, Bartoli, Marc, Villard, Laurent, Roux, Jean-Christophe

“…Abstract Rett syndrome (RTT) is a severe X-linked neurodevelopmental disorder that is primarily caused by mutations in the methyl CpG binding protein 2 gene (…”
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Rett syndrome from bench to bedside: recent advances [version 1; peer review: 2 approved] by Ehinger, Yann, Matagne, Valerie, Villard, Laurent, Roux, Jean-Christophe

“…Rett Syndrome is a severe neurological disorder mainly due to de novo mutations in the methyl-CpG-binding protein 2 gene ( MECP2). Mecp2 is known to play a…”
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Analysis of Astroglial Secretomic Profile in the Mecp2-Deficient Male Mouse Model of Rett Syndrome by Ehinger, Yann, Matagne, Valerie, Cunin, Valérie, Borloz, Emilie, Seve, Michel, Bourgoin-Voillard, Sandrine, Borges-Correia, Ana, Villard, Laurent, Roux, Jean-Christophe

“…Mutations in the X-linked gene are responsible for Rett syndrome (RTT), a severe neurological disorder. MECP2 is a transcriptional modulator that finely…”
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Huntingtin phosphorylation governs BDNF homeostasis and improves the phenotype of Mecp2 knockout mice by Ehinger, Yann, Bruyère, Julie, Panayotis, Nicolas, Abada, Yah‐Se, Borloz, Emilie, Matagne, Valérie, Scaramuzzino, Chiara, Vitet, Hélène, Delatour, Benoit, Saidi, Lydia, Villard, Laurent, Saudou, Frédéric, Roux, Jean‐Christophe

“…Mutations in the X‐linked MECP2 gene are responsible for Rett syndrome (RTT), a severe neurological disorder for which there is no treatment. Several studies…”
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Ultrasound-Mediated Blood-Brain Barrier Opening Improves Whole Brain Gene Delivery in Mice by Felix, Marie-Solenne, Borloz, Emilie, Metwally, Khaled, Dauba, Ambre, Larrat, Benoit, Matagne, Valerie, Ehinger, Yann, Villard, Laurent, Novell, Anthony, Mensah, Serge, Roux, Jean-Christophe

“…Gene therapy represents a powerful therapeutic tool to treat diseased tissues and provide a durable and effective correction. The central nervous system (CNS)…”
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PI3-Kinase p110β in Cortical Circuitries and Cocaine-Dependent Maladaptative Behaviors by Ehinger, Yann

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PI3-Kinase p110β in Cortical Circuitries and Cocaine-Dependent Maladaptive Behaviors by Ehinger, Yann

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State‐of‐the‐art therapies for Rett syndrome by Panayotis, Nicolas, Ehinger, Yann, Felix, Marie Solenne, Roux, Jean‐Christophe

“…Rett syndrome (RTT) is an X‐linked neurogenetic disorder caused by mutations of the MECP2 (methyl‐CpG‐binding protein 2) gene. Over two decades of work…”
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A non-hallucinogenic psychedelic analogue with therapeutic potential by Cameron, Lindsay P., Tombari, Robert J., Lu, Ju, Pell, Alexander J., Hurley, Zefan Q., Ehinger, Yann, Vargas, Maxemiliano V., McCarroll, Matthew N., Taylor, Jack C., Myers-Turnbull, Douglas, Liu, Taohui, Yaghoobi, Bianca, Laskowski, Lauren J., Anderson, Emilie I., Zhang, Guoliang, Viswanathan, Jayashri, Brown, Brandon M., Tjia, Michelle, Dunlap, Lee E., Rabow, Zachary T., Fiehn, Oliver, Wulff, Heike, McCorvy, John D., Lein, Pamela J., Kokel, David, Ron, Dorit, Peters, Jamie, Zuo, Yi, Olson, David E.

“…The psychedelic alkaloid ibogaine has anti-addictive properties in both humans and animals 1 . Unlike most medications for the treatment of substance use…”
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The Small G-Protein Rac1 Promotes Neuroadaptations that Underlie Alcohol Use Disorder by Hoisington, Zachary W., Salvi, Alexandra, Phamluong, Khanhky, Ehinger, Yann, Ron, Dorit

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Identification of Novel BDNF-Specific Corticostriatal Circuitries by Ehinger, Yann, Soneja, Drishti, Phamluong, Khanhky, Salvi, Alexandra, Ron, Dorit

“…Brain-derived neurotrophic factor (BDNF) is released from axon terminals originating in the cerebral cortex onto striatal neurons. Here, we characterized BDNF…”
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The BDNF Val68Met polymorphism causes a sex specific alcohol preference over social interaction and also acute tolerance to the anxiolytic effects of alcohol, a phenotype driven by malfunction of BDNF in the ventral hippocampus of male mice by Moffat, Jeffrey J., Sakhai, Samuel A., Hoisington, Zachary W., Ehinger, Yann, Ron, Dorit

“…Background The brain-derived neurotrophic factor (BDNF) Valine 66 to Methionine human polymorphism results in impaired activity-dependent BDNF release and has…”
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Differential correlation of serum BDNF and microRNA content in rats with rapid or late onset of heavy alcohol use by Ehinger, Yann, Phamluong, Khanhky, Darevesky, David, Welman, Melanie, Moffat, Jeffrey J., Sakhai, Samuel A., Whiteley, Ellanor L., Berger, Anthony L., Laguesse, Sophie, Farokhnia, Mehdi, Leggio, Lorenzo, Lordkipanidzé, Marie, Ron, Dorit

“…Heavy alcohol use reduces the levels of the brain‐derived neurotrophic factor (BDNF) in the prefrontal cortex of rodents through the upregulation of microRNAs…”
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