Search Results - "Eguren, Manuel"

Dual-spindle formation in zygotes keeps parental genomes apart in early mammalian embryos by Reichmann, Judith, Nijmeijer, Bianca, Hossain, M Julius, Eguren, Manuel, Schneider, Isabell, Politi, Antonio Z, Roberti, M Julia, Hufnagel, Lars, Hiiragi, Takashi, Ellenberg, Jan

“…At the beginning of mammalian life, the genetic material from each parent meets when the fertilized egg divides. It was previously thought that a single…”
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The cell proliferation antigen Ki-67 organises heterochromatin by Sobecki, Michal, Mrouj, Karim, Camasses, Alain, Parisis, Nikolaos, Nicolas, Emilien, Llères, David, Gerbe, François, Prieto, Susana, Krasinska, Liliana, David, Alexandre, Eguren, Manuel, Birling, Marie-Christine, Urbach, Serge, Hem, Sonia, Déjardin, Jérôme, Malumbres, Marcos, Jay, Philippe, Dulic, Vjekoslav, Lafontaine, Denis Lj, Feil, Robert, Fisher, Daniel

“…Antigen Ki-67 is a nuclear protein expressed in proliferating mammalian cells. It is widely used in cancer histopathology but its functions remain unclear…”
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The anaphase-promoting complex/cyclosome (APC/C): cell-cycle-dependent and -independent functions by Manchado, Eusebio, Eguren, Manuel, Malumbres, Marcos

“…The APC/C (anaphase-promoting complex/cyclosome) is an E3 ubiquitin ligase that targets specific substrates for degradation by the 26S proteasome. APC/C…”
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Non-mitotic functions of the Anaphase-Promoting Complex by Eguren, Manuel, Manchado, Eusebio, Malumbres, Marcos

“…The Anaphase-Promoting Complex or Cyclosome (APC/C) is an E3 ubiquitin ligase whose activation requires the binding of a cofactor, either Cdc20 or Cdh1. While…”
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The APC/C cofactor Cdh1 prevents replicative stress and p53-dependent cell death in neural progenitors by Eguren, Manuel, Porlan, Eva, Manchado, Eusebio, García-Higuera, Irene, Cañamero, Marta, Fariñas, Isabel, Malumbres, Marcos

“…The E3-ubiquitin ligase APC/C-Cdh1 is essential for endoreduplication but its relevance in the mammalian mitotic cell cycle is still unclear. Here we show that…”
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A Synthetic Lethal Interaction between APC/C and Topoisomerase Poisons Uncovered by Proteomic Screens by Eguren, Manuel, Álvarez-Fernández, Mónica, García, Fernando, López-Contreras, Andrés J., Fujimitsu, Kazuyuki, Yaguchi, Hiroko, Luque-García, José Luis, Fernández-Capetillo, Oscar, Muñoz, Javier, Yamano, Hiroyuki, Malumbres, Marcos

“…The Anaphase-promoting complex/cyclosome (APC/C) cofactor Cdh1 modulates cell proliferation by targeting multiple cell-cycle regulators for ubiquitin-dependent…”
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APC/CCdh1 Enables Removal of Shugoshin-2 from the Arms of Bivalent Chromosomes by Moderating Cyclin-Dependent Kinase Activity by Rattani, Ahmed, Ballesteros Mejia, Randy, Roberts, Katherine, Roig, Maurici B., Godwin, Jonathan, Hopkins, Michael, Eguren, Manuel, Sanchez-Pulido, Luis, Okaz, Elwy, Ogushi, Sugako, Wolna, Magda, Metson, Jean, Pendás, Alberto M., Malumbres, Marcos, Novák, Béla, Herbert, Mary, Nasmyth, Kim

“…In mammalian females, germ cells remain arrested as primordial follicles. Resumption of meiosis is heralded by germinal vesicle breakdown, condensation of…”
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High-resolution line-scan Brillouin microscopy for live imaging of mechanical properties during embryo development by Bevilacqua, Carlo, Gomez, Juan Manuel, Fiuza, Ulla-Maj, Chan, Chii Jou, Wang, Ling, Hambura, Sebastian, Eguren, Manuel, Ellenberg, Jan, Diz-Muñoz, Alba, Leptin, Maria, Prevedel, Robert

“…Brillouin microscopy can assess mechanical properties of biological samples in a three-dimensional (3D), all-optical and hence non-contact fashion, but its…”
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Targeting Mitotic Exit Leads to Tumor Regression In Vivo: Modulation by Cdk1, Mastl, and the PP2A/B55α,δ Phosphatase by Manchado, Eusebio, Guillamot, María, de Cárcer, Guillermo, Eguren, Manuel, Trickey, Michelle, García-Higuera, Irene, Moreno, Sergio, Yamano, Hiroyuki, Cañamero, Marta, Malumbres, Marcos

“…Targeting mitotic exit has been recently proposed as a relevant therapeutic approach against cancer. By using genetically engineered mice, we show that the…”
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Cdh1 Regulates Osteoblast Function through an APC/C-Independent Modulation of Smurf1 by Wan, Lixin, Zou, Weiguo, Gao, Daming, Inuzuka, Hiroyuki, Fukushima, Hidefumi, Berg, Anders H., Drapp, Rebecca, Shaik, Shavali, Hu, Dorothy, Lester, Chantel, Eguren, Manuel, Malumbres, Marcos, Glimcher, Laurie H., Wei, Wenyi

“…The APC/Cdh1 E3 ubiquitin ligase plays an essential role in both mitotic exit and G1/S transition by targeting key cell-cycle regulators for destruction. There…”
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Live imaging of cell division in preimplantation mouse embryos using inverted light-sheet microscopy by Reichmann, Judith, Eguren, Manuel, Lin, Yu, Schneider, Isabell, Ellenberg, Jan

“…Systematic studies of cell divisions at the beginning of mammalian life are of fundamental importance for our understanding of embryonic development and…”
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Retraction Note: An actin-dependent spindle position checkpoint ensures the asymmetric division in mouse oocytes by Metchat, Aïcha, Eguren, Manuel, Hossain, Julius M., Politi, Antonio Z., Huet, Sébastien, Ellenberg, Jan

“…This paper has been retracted as it was submitted by the corresponding author A.M. without the knowledge or consent of the other researchers listed on the…”
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Retraction: An actin-dependent spindle position checkpoint ensures the asymmetric division in mouse oocytes by Metchat, Aïcha, Eguren, Manuel, Hossain, Julius M, Politi, Antonio Z, Huet, Sébastien, Ellenberg, Jan

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An actin-dependent spindle position checkpoint ensures the asymmetric division in mouse oocytes by Metchat, Aïcha, Eguren, Manuel, Hossain, Julius M., Politi, Antonio Z., Huet, Sébastien, Ellenberg, Jan

“…Faithful chromosome segregation, during meiosis, is of critical importance to prevent aneuploidy in the resulting embryo. In mammalian oocytes, the segregation…”
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Cdk4 and Cdk6 cooperate in counteracting the INK4 family of inhibitors during murine leukemogenesis by Rodríguez-Díez, Esther, Quereda, Victor, Bellutti, Florian, Prchal-Murphy, Michaela, Partida, David, Eguren, Manuel, Kollmann, Karoline, Gómez de Cedrón, Marta, Dubus, Pierre, Cañamero, Marta, Martínez, Dolores, Sexl, Veronika, Malumbres, Marcos

“…Cdk4 and Cdk6 are related protein kinases that bind d-type cyclins and regulate cell-cycle progression. Cdk4/6 inhibitors are currently being used in advanced…”
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APC/C Cdh1 Enables Removal of Shugoshin-2 from the Arms of Bivalent Chromosomes by Moderating Cyclin-Dependent Kinase Activity by Rattani, Ahmed, Ballesteros Mejia, Randy, Roberts, Katherine, Roig, Maurici B, Godwin, Jonathan, Hopkins, Michael, Eguren, Manuel, Sanchez-Pulido, Luis, Okaz, Elwy, Ogushi, Sugako, Wolna, Magda, Metson, Jean, Pendás, Alberto M, Malumbres, Marcos, Novák, Béla, Herbert, Mary, Nasmyth, Kim

“…In mammalian females, germ cells remain arrested as primordial follicles. Resumption of meiosis is heralded by germinal vesicle breakdown, condensation of…”
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Abstract PR11: APC/CCdh1 maintains primordial follicles, germinal vesicle arrest and ensures balanced segregation of chromosomes by enabling removal of Shugoshin-2 from chromosomes arms by Rattani, Ahmed, Mejia, Randy Ballestros, Roberts, Katherine, Roig, Maurici B, Godwin, Jonathan, Eguren, Manuel, Ogushi, Sugako, Okaz, Elwy, Pendas, Alberto, Marcos, Malumbres, Herbert, Mary, Nasmyth, Kim

“…Abstract Germ cells in mammals, including humans, remain arrested at the primordial follicle stage from a few days to many years depending on the species. At…”
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Deregulated expression of Cdc6 in the skin facilitates papilloma formation and affects the hair growth cycle by Búa, Sabela, Sotiropoulou, Peggy, Sgarlata, Cecilia, Borlado, Luis R, Eguren, Manuel, Domínguez, Orlando, Ortega, Sagrario, Malumbres, Marcos, Blanpain, Cedric, Méndez, Juan

“…Cdc6 encodes a key protein for DNA replication, responsible for the recruitment of the MCM helicase to replication origins during the G1 phase of the cell…”
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Targeting Mitotic Exit Leads to Tumor Regression InaaVivo: Modulation by Cdk1, Mastl, and the PP2A/B55 alpha ,I Phosphatase by Manchado, Eusebio, Guillamot, Maria, de Carcer, Guillermo, Eguren, Manuel, Trickey, Michelle, Garcia-Higuera, Irene, Moreno, Sergio, Yamano, Hiroyuki, Canamero, Marta, Malumbres, Marcos

“…Targeting mitotic exit has been recently proposed as a relevant therapeutic approach against cancer. By using genetically engineered mice, we show that the…”
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Deregulated expression of Cdc6 in the skin facilitates papilloma formation and affects the hair growth cycle by Búa, Sabela, Sotiropoulou, Peggy, Sgarlata, Cecilia, Borlado, Luis R, Eguren, Manuel, Domínguez, Orlando, Ortega, Sagrario, Malumbres, Marcos, Blanpain, Cedric, Méndez, Juan

“…Cdc6 encodes a key protein for DNA replication, responsible for the recruitment of the MCM helicase to replication origins during the G1 phase of the cell…”
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