Search Results - "Egorov, Artyom A"
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Structure-functional characterization of Lactococcus AbiA phage defense system
Published in Nucleic acids research (08-05-2024)“…Bacterial reverse transcriptases (RTs) are a large and diverse enzyme family. AbiA, AbiK and Abi-P2 are abortive infection system (Abi) RTs that mediate…”
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Genome-encoded ABCF factors implicated in intrinsic antibiotic resistance in Gram-positive bacteria: VmlR2, Ard1 and CplR
Published in Nucleic acids research (22-05-2023)“…Abstract Genome-encoded antibiotic resistance (ARE) ATP-binding cassette (ABC) proteins of the F subfamily (ARE-ABCFs) mediate intrinsic resistance in diverse…”
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svist4get: a simple visualization tool for genomic tracks from sequencing experiments
Published in BMC bioinformatics (06-03-2019)“…High-throughput sequencing often provides a foundation for experimental analyses in the life sciences. For many such methods, an intermediate layer of…”
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The ABCF ATPase New1 resolves translation termination defects associated with specific tRNAArg and tRNALys isoacceptors in the P site
Published in Nucleic acids research (01-09-2024)“…The efficiency of translation termination is determined by the nature of the stop codon as well as its context. In eukaryotes, recognition of the A-site stop…”
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Human Tissues Exhibit Diverse Composition of Translation Machinery
Published in International journal of molecular sciences (06-05-2023)“…While protein synthesis is vital for the majority of cell types of the human body, diversely differentiated cells require specific translation regulation. This…”
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uORF4u: a tool for annotation of conserved upstream open reading frames
Published in Bioinformatics (Oxford, England) (04-05-2023)“…Abstract Summary Upstream open reading frames (uORFs, often encoding so-called leader peptides) can regulate translation and transcription of downstream main…”
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Ribo-Seq and RNA-Seq of TMA46 ( DFRP1) and GIR2 ( DFRP2) knockout yeast strains [version 1; peer review: 3 approved]
Published in F1000 research (2021)“…In eukaryotes, stalled and collided ribosomes are recognized by several conserved multicomponent systems, which either block protein synthesis in situ and…”
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Translatome and transcriptome analysis of TMA20 (MCT-1) and TMA64 (eIF2D) knockout yeast strains
Published in Data in brief (01-04-2019)“…TMA20 (MCT-1), TMA22 (DENR) and TMA64 (eIF2D) are eukaryotic translation factors involved in ribosome recycling and re-initiation. They operate with P-site…”
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The structural basis of hyperpromiscuity in a core combinatorial network of type II toxin-antitoxin and related phage defense systems
Published in Proceedings of the National Academy of Sciences - PNAS (15-08-2023)“…Toxin-antitoxin (TA) systems are a large group of small genetic modules found in prokaryotes and their mobile genetic elements. Type II TAs are encoded as…”
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Mechanism of phage sensing and restriction by toxin-antitoxin-chaperone systems
Published in Cell host & microbe (10-07-2024)“…Toxin-antitoxins (TAs) are prokaryotic two-gene systems composed of a toxin neutralized by an antitoxin. Toxin-antitoxin-chaperone (TAC) systems additionally…”
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A standard knockout procedure alters expression of adjacent loci at the translational level
Published in Nucleic acids research (08-11-2021)“…Abstract The Saccharomyces cerevisiae gene deletion collection is widely used for functional gene annotation and genetic interaction analyses. However, the…”
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A Comprehensive Resource for Exploring Antiphage Defense: DefenseFinder Webservice,Wiki and Databases
Published in Peer community journal (25-09-2024)Get full text
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