Search Results - "Egorov, Andrej"

The problem of bacterial complications post respiratory viral infections by Egorov, Andrej

“…ABSTRACT Every person over the course of their lifetime is repeatedly infected by a variety of respiratory viruses that represent risk factors for the…”
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UniFluVec influenza vector induces heterosubtypic protection in ferrets after intranasal administration despite high attenuation by Ferko, Boris, Krokhin, Artem, Nebolsin, Vladimir, Egorov, Andrej

“…BACKGROUND: Current influenza vaccines primarily elicit strain-specific immunity, providing limited protection against heterologous influenza strains…”
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IgGκ Signal Peptide Enhances the Efficacy of an Influenza Vector Vaccine against Respiratory Syncytial Virus Infection in Mice by Pulkina, Anastasia, Vasilyev, Kirill, Muzhikyan, Arman, Sergeeva, Mariia, Romanovskaya-Romanko, Ekaterina, Shurygina, Anna-Polina, Shuklina, Marina, Vasin, Andrey, Stukova, Marina, Egorov, Andrej

“…Intranasal vaccination using influenza vectors is a promising approach to developing vaccines against respiratory pathogens due to the activation of the…”
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Oncolytic influenza A virus expressing interleukin-15 decreases tumor growth in vivo by Hock, Karin, PhD, Laengle, Johannes, MD, Kuznetsova, Irina, MSc, Egorov, Andrej, MD, PhD, Hegedus, Balazs, PhD, Dome, Balazs, MD, PhD, Wekerle, Thomas, MD, Sachet, Monika, PhD, Bergmann, Michael, MD

“…Background Interleukin-15 has become a promising molecule in the context of eliciting an effective, antitumor immune response because it is able to stimulate…”
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The impact of the global distribution of bats on mortality in COVID-19 patients by Egorov, Andrej, Romanova, Julia

“…Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) originated in November 2019 in China and quickly spread throughout the world causing a disease…”
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Intranasal Immunization with the Influenza A Virus Encoding Truncated NS1 Protein Protects Mice from Heterologous Challenge by Restraining the Inflammatory Response in the Lungs by Vasilyev, Kirill, Shurygina, Anna-Polina, Sergeeva, Maria, Stukova, Marina, Egorov, Andrej

“…Influenza viruses with an impaired NS1 protein are unable to antagonize the innate immune system and, therefore, are highly immunogenic because of the…”
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Interleukin-24 inhibits influenza A virus replication in vitro through induction of toll-like receptor 3 dependent apoptosis by Weiss, René, Laengle, Johannes, Sachet, Monika, Shurygina, Anna-Polina, Kiselev, Oleg, Egorov, Andrej, Bergmann, Michael

“…•IL-24 reveals an anti-viral effect against influenza A virus infected cells.•The anti-viral effect of IL-24 involves TLR3 mediated apoptosis.•Mcl-1 is a key…”
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Single intranasal immunization with a high dose of influenza vector protects against infection with heterologous influenza virus and SARS-CoV-2 in ferrets and hamsters by Egorov, Andrej, Krokhin, Artem A., Leneva, Irina A., Korabliov, Pavel, Loiteris, Pavelas, Nebolsin, Vladimir E.

“…BACKGROUND: The challenge of vaccine effectiveness against viruses that undergo constant antigenic changes during evolution is currently being addressed by…”
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Oncolytic effects of a novel influenza A virus expressing interleukin-15 from the NS reading frame by van Rikxoort, Marijke, Michaelis, Martin, Wolschek, Markus, Muster, Thomas, Egorov, Andrej, Seipelt, Joachim, Doerr, Hans Wilhelm, Cinatl, Jr, Jindrich

“…Oncolytic influenza A viruses with deleted NS1 gene (delNS1) replicate selectively in tumour cells with defective interferon response and/or activated…”
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Evidence for the extracellular delivery of influenza NS1 protein by Pulkina, Anastasia A., Sergeeva, Maria V., Krokhin, Artem, Stukova, Marina A., Egorov, Andrej

“…We constructed a reporter influenza A/Puerto Rico/8/1934 virus expressing truncated 124aa N-terminal NS1 protein fused to a luciferase reporter sequence…”
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Single HA2 mutation increases the infectivity and immunogenicity of a live attenuated H5N1 intranasal influenza vaccine candidate lacking NS1 by Krenn, Brigitte M, Egorov, Andrej, Romanovskaya-Romanko, Ekaterina, Wolschek, Markus, Nakowitsch, Sabine, Ruthsatz, Tanja, Kiefmann, Bettina, Morokutti, Alexander, Humer, Johannes, Geiler, Janina, Cinatl, Jindrich, Michaelis, Martin, Wressnigg, Nina, Sturlan, Sanda, Ferko, Boris, Batishchev, Oleg V, Indenbom, Andrey V, Zhu, Rong, Kastner, Markus, Hinterdorfer, Peter, Kiselev, Oleg, Muster, Thomas, Romanova, Julia

“…H5N1 influenza vaccines, including live intranasal, appear to be relatively less immunogenic compared to seasonal analogs. The main influenza virus surface…”
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Immunogenicity and Protection Efficacy of Replication-Deficient Influenza A Viruses with Altered NS1 Genes by FERKO, Boris, STASAKOVA, Jana, ROMANOVA, Julia, KITTEL, Christian, SEREINIG, Sabine, KATINGER, Hermann, EGOROV, Andrej

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Sublingual immunization with a live attenuated influenza a virus lacking the nonstructural protein 1 induces broad protective immunity in mice by Park, Hae-Jung, Ferko, Boris, Byun, Young-Ho, Song, Joo-Hye, Han, Gye-Yeong, Roethl, Elisabeth, Egorov, Andrej, Muster, Thomas, Seong, Baiklin, Kweon, Mi-Na, Song, Manki, Czerkinsky, Cecil, Nguyen, Huan H

“…The nonstructural protein 1 (NS1) of influenza A virus (IAV) enables the virus to disarm the host cell type 1 IFN defense system. Mutation or deletion of the…”
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Adaptive mutation in nuclear export protein allows stable transgene expression in a chimaeric influenza A virus vector by Kuznetsova, Irina, Shurygina, Anna-Polina, Wolf, Brigitte, Wolschek, Markus, Enzmann, Florian, Sansyzbay, Abylay, Khairullin, Berik, Sandybayev, Nurlan, Stukova, Marina, Kiselev, Oleg, Egorov, Andrej, Bergmann, Michael

“…The development of influenza virus vectors with long insertions of foreign sequences remains difficult due to the small size and instable nature of the virus…”
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Targeting an Oncolytic Influenza A Virus to Tumor Tissue by Elastase by Kuznetsova, Irina, Arnold, Tobias, Aschacher, Thomas, Schwager, Cornelia, Hegedus, Balazs, Garay, Tamas, Stukova, Marina, Pisareva, Maria, Pleschka, Stephan, Bergmann, Michael, Egorov, Andrej

“…Oncolytic viruses are currently established as a novel type of immunotherapy. The challenge is to safely target oncolytic viruses to tumors. Previously, we…”
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The Potential of Influenza HA-Specific Immunity in Mitigating Lethality of Postinfluenza Pneumococcal Infections by Klausberger, Miriam, Leneva, Irina A, Falynskova, Irina N, Vasiliev, Kirill, Poddubikov, Alexander V, Lindner, Claudia, Kartaschova, Nadezhda P, Svitich, Oxana A, Stukova, Marina, Grabherr, Reingard, Egorov, Andrej

“…Influenza virus infections pre-dispose an individual to secondary pneumococcal infections, which represent a serious public health concern. Matching influenza…”
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Establishment of a Chimeric, Replication-Deficient Influenza A Virus Vector by Modulation of Splicing Efficiency by WOLSCHEK, Markus, SAMM, Elisabeth, BERGMANN, Michael, SEPER, Helena, STURLAN, Sanda, KUZNETSOVA, Irina, SCHWAGER, Cornelia, KHASSIDOV, Alexandra, KITTEL, Christian, MUSTER, Thomas, EGOROV, Andrej

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Antimycotic-Antibiotic Amphotericin B Promotes Influenza Virus Replication in Cell Culture by Roethl, Elisabeth, Gassner, Manuela, Krenn, Brigitte M, Romanovskaya-Romanko, Ekaterina A, Seper, Helena, Romanova, Julia, Nakowitsch, Sabine, Sturlan, Sanda, Wolschek, Markus, Sirotkin, Alexej, Kiselev, Oleg, Muster, Thomas, Egorov, Andrej

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Live Attenuated Influenza Virus Expressing Human Interleukin-2 Reveals Increased Immunogenic Potential in Young and Aged Hosts by FERKO, Boris, KITTEL, Christian, ROMANOVA, Julia, SEREINIG, Sabine, KATINGER, Hermann, EGOROV, Andrej

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The challenges of creating a universal influenza vaccine by Egorov, Andrej Y.

“…ABSTRACT The lack of population immunity to the periodically emerging pandemic influenza strains makes influenza infection especially dangerous. The fragmented…”
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