Search Results - "Egner, P A"

Protective alterations in phase 1 and 2 metabolism of aflatoxin B1 by oltipraz in Residents of Qidong, People's Republic of China by WANG, J.-S, XINNAN SHEN, JACOBSON, L. P, MUNOZ, A, HELZLSOUER, K. J, GROOPMAN, J. D, KENSLER, T. W, XIA HE, ZHU, Y.-R, ZHANG, B.-C, WANG, J.-B, QIAN, G.-S, KUANG, S.-Y, ZARBA, A, EGNER, P. A

“…Residents of Qidong, People's Republic of China, are at high risk for development of hepatocellular carcinoma, in part due to consumption of foods contaminated…”
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Myeloperoxidase as a biomarker of skin irritation and inflammation by Trush, M A, Egner, P A, Kensler, T W

“…Topical exposure to many occupational and environmental chemicals is often accompanied by the induction of a cutaneous inflammatory response characterized by…”
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Oltipraz chemoprevention trial in Qidong, People's Republic of China: modulation of serum aflatoxin albumin adduct biomarkers by Kensler, T W, He, X, Otieno, M, Egner, P A, Jacobson, L P, Chen, B, Wang, J S, Zhu, Y R, Zhang, B C, Wang, J B, Wu, Y, Zhang, Q N, Qian, G S, Kuang, S Y, Fang, X, Li, Y F, Yu, L Y, Prochaska, H J, Davidson, N E, Gordon, G B, Gorman, M B, Zarba, A, Enger, C, Muñoz, A, Helzlsouer, K J

“…In 1995, 234 adults from Qidong, People's Republic of China, were enrolled and followed in a Phase IIa 4-methyl-5-(N-2-pyrazinyl)-1,2-dithiole-3-thione…”
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Oltipraz chemoprevention trial in Qidong, People's Republic of China: study design and clinical outcomes by L P Jacobson, B C Zhang, Y R Zhu, J B Wang, Y Wu, Q N Zhang, L Y Yu, G S Qian, S Y Kuang, Y F Li, X Fang, A Zarba, B Chen, C Enger, N E Davidson, M B Gorman, G B Gordon, H J Prochaska, P A Egner, J D Groopman, A Muñoz, K J Helzlsouer, T W Kensler

“…In 1995, 234 adults from Qidong, Jiangsu Province, People's Republic of China, where hepatocellular carcinoma is the leading cause of cancer deaths and…”
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Regulation of phase 2 enzyme induction by oltipraz and other dithiolethiones by Egner, P A, Kensler, T W, Prestera, T, Talalay, P, Libby, A H, Joyner, H H, Curphey, T J

“…4-Methyl-5-pyrazinyl-3H-1,2-dithiole-3-thione (oltipraz) and several other dithiolethiones protect against the acute toxicities of many xenobiotics and are…”
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Intermittent dosing with oltipraz : relationship between chemoprevention of aflatoxin-induced tumorigenesis and induction of glutathione S-transferases by PRIMIANO, T, EGNER, P. A, SUTTER, T. R, KELLOFF, G. J, ROEBUCK, B. D, KENSLER, T. W

“…Oltipraz [5-(2-pyrazinyl)-4-methyl-1,2-dithiole-3-thione] protects against chemical carcinogenesis in several animal models and is currently under evaluation…”
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Mechanism of protection against aflatoxin tumorigenicity in rats fed 5-(2-pyrazinyl)-4-methyl-1,2-dithiol-3-thione (oltipraz) and related 1,2-dithiol-3-thiones and 1,2-dithiol-3-ones by KENSLER, T. W, EGNER, P. A, DOLAN, P. M, GROOPMAN, J. D, ROEBUCK, B. D

“…1,2-Dithiol-3-thiones, reported constituents of cruciferous vegetables, are five-membered cyclic sulfur-containing compounds with antioxidant,…”
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Predictive value of molecular dosimetry: individual versus group effects of oltipraz on aflatoxin-albumin adducts and risk of liver cancer by Kensler, T W, Gange, S J, Egner, P A, Dolan, P M, Muñoz, A, Groopman, J D, Rogers, A E, Roebuck, B D

“…Studies in animals and humans have established serum aflatoxin-albumin adducts as biomarkers of exposure to aflatoxin B1 (AFB1), a food-borne hepatocarcinogen…”
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Chlorophyllin Intervention Reduces Aflatoxin-DNA Adducts in Individuals at High Risk for Liver Cancer by Egner, Patricia A., Wang, Jin-Bing, Zhu, Yuan-Rong, Zhang, Bao-Chu, Wu, Yan, Zhang, Qi-Nan, Qian, Geng-Sun, Kuang, Shuang-Yuan, Gange, Stephen J., Jacobson, Lisa P., Helzlsouer, Kathy J., Bailey, George S., Groopman, John D., Kensler, Thomas W.

“…Residents of Qidong, People's Republic of China, are at high risk for development of hepatocellular carcinoma, in part from consumption of foods contaminated…”
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Molecular dosimetry of urinary aflatoxin-N7-guanine and serum aflatoxin-albumin adducts predicts chemoprotection by 1,2-dithiole-3-thione in rats by Groopman, J D, DeMatos, P, Egner, P A, Love-Hunt, A, Kensler, T W

“…Hepatocellular carcinoma has one of the poorest 5 year survival rates of any human cancer. Preventive measures offer the best possibility of ameliorating this…”
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Transcriptional control of glutathione S-transferase gene expression by the chemoprotective agent 5-(2-pyrazinyl)-4-methyl-1,2-dithiole-3-thione (oltipraz) in rat liver by DAVIDSON, N. E, EGNER, P. A, KENSLER, T. W

“…The substituted 1,2-dithiole-3-thione oltipraz [5-(2-pyrazinyl)-4-methyl-1,2-dithiole-3-thione] protects against the acute and chronic toxicities of many…”
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Levels of aflatoxin-albumin biomarkers in rat plasma are modulated by both long-term and transient interventions with oltipraz by Egner, P A, Gange, S J, Dolan, P M, Groopman, J D, Muñoz, A, Kensler, T W

“…The validation process for biomarkers to be used for monitoring the efficacy of preventive interventions in humans includes assessments of whether levels of…”
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Modulation of aflatoxin metabolism, aflatoxin-N7-guanine formation, and hepatic tumorigenesis in rats fed ethoxyquin: role of induction of glutathione S-transferases by KENSLER, T. W, EGNER, P. A, DAVIDSON, N. E, ROEBUCK, B. D, PIKUL, A, GROOPMAN, J. D

“…The effects of dietary administration of ethoxyquin (EQ) on aflatoxin B1 (AFB1) metabolism, DNA adduct formation and removal, and hepatic tumorigenesis were…”
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Generation of DNA base modification following treatment of cultured murine keratinocytes with benzoyl peroxide by KING, J. K, EGNER, P. A, KENSLER, T. W

“…Benzoyl peroxide (BzPO) is a free radical generating compound that acts as a tumor promoter and progressor in mouse skin. BzPO is cleaved in the presence of…”
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DNA Adduct Formation by 2,6-Dimethyl-, 3,5-Dimethyl-, and 3-Ethylaniline in Vivo in Mice by Skipper, Paul L, Trudel, Laura J, Kensler, Thomas W, Groopman, John D, Egner, Patricia A, Liberman, Rosa G, Wogan, Gerald N, Tannenbaum, Steven R

“…Aromatic amines such as 2-naphthylamine and 4-aminobiphenyl are established human bladder carcinogens. Experimental evidence for carcinogenicity of monocylic…”
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Identification and characterization of chlorin e(4) ethyl ester in sera of individuals participating in the chlorophyllin chemoprevention trial by Egner, P A, Stansbury, K H, Snyder, E P, Rogers, M E, Hintz, P A, Kensler, T W

“…Chlorophyllin (CHL), a mixture of water soluble derivatives of chlorophyll, has been shown to be an effective inhibitor of aflatoxin B(1) (AFB(1))…”
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Effects of a biomimetic superoxide dismutase on complete and multistage carcinogenesis in mouse skin by Egner, P A, Kensler, T W

“…The effects of a selective detoxifier of the proximate oxygen radical, superoxide anion, on the induction of tumors in the skin of CD-1 mice by either the…”
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Role of inflammatory cells in the metabolic activation of polycyclic aromatic hydrocarbons in mouse skin by Kensler, T W, Egner, P A, Moore, K G, Taffe, B G, Twerdok, L E, Trush, M A

“…Oxidants, such as those generated by activated polymorphonuclear leukocytes (PMNs) during inflammation, have been implicated in the metabolic activation of…”
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Oltipraz chemoprevention trial in Qidong, People's Republic of china: results of urine genotoxicity assays as related to smoking habits by CAMOIRANO, Anna, BAGNASCO, Maria, KENSLER, Thomas W, DE FLORA, Silvio, BENNICELLI, Carlo, CARTIGLIA, Cristina, WANG, Jin-Bing, ZHANG, Bao-Chu, ZHU, Yuan-Rong, QIAN, Geng-Sun, EGNER, Patricia A, JACOBSON, Lisa P

“…A Phase II chemoprevention trial was carried out in Qidong, Jiangsu Province, People's Republic of China. The recruited subjects, all of whom were positive for…”
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Modification of aflatoxin B1 binding to DNA in vivo in rats fed phenolic antioxidants, ethoxyquin and a dithiothione by Kensler, T W, Egner, P A, Trush, M A, Bueding, E, Groopman, J D

“…The effects of dietary administration of 3,5-di-tert-butyl-4-hydroxytoluene (BHT), 2(3)-tert-butyl-4-hydroxyanisole (BHA), ethoxyquin (EQ) and…”
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