MiR-219a-5p Enriched Extracellular Vesicles Induce OPC Differentiation and EAE Improvement More Efficiently Than Liposomes and Polymeric Nanoparticles

Remyelination is a key aspect in multiple sclerosis pathology and a special effort is being made to promote it. However, there is still no available treatment to regenerate myelin and several strategies are being scrutinized. Myelination is naturally performed by oligodendrocytes and microRNAs have...

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Published in:	Pharmaceutics Vol. 12; no. 2; p. 186
Main Authors:	Osorio-Querejeta, I, Carregal-Romero, S, Ayerdi-Izquierdo, A, Mäger, I, A, Nash L, Wood, M, Egimendia, A, Betanzos, M, Alberro, A, Iparraguirre, L, Moles, L, Llarena, I, Möller, M, Goñi-de-Cerio, F, Bijelic, G, Ramos-Cabrer, P, Muñoz-Culla, M, Otaegui, D
Format:	Journal Article
Language:	English
Published:	Switzerland MDPI 21-02-2020 MDPI AG
Subjects:	central nervous system drug delivery multiple sclerosis myelin neurodegeneration remyelination Highlights
Online Access:	Get full text
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Summary:	Remyelination is a key aspect in multiple sclerosis pathology and a special effort is being made to promote it. However, there is still no available treatment to regenerate myelin and several strategies are being scrutinized. Myelination is naturally performed by oligodendrocytes and microRNAs have been postulated as a promising tool to induce oligodendrocyte precursor cell differentiation and therefore remyelination. Herein, DSPC liposomes and PLGA nanoparticles were studied for miR-219a-5p encapsulation, release and remyelination promotion. In parallel, they were compared with biologically engineered extracellular vesicles overexpressing miR-219a-5p. Interestingly, extracellular vesicles showed the highest oligodendrocyte precursor cell differentiation levels and were more effective than liposomes and polymeric nanoparticles crossing the blood-brain barrier. Finally, extracellular vesicles were able to improve EAE animal model clinical evolution. Our results indicate that the use of extracellular vesicles as miR-219a-5p delivery system can be a feasible and promising strategy to induce remyelination in multiple sclerosis patients.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	1999-4923 1999-4923
DOI:	10.3390/pharmaceutics12020186