Search Results - "Eggo, M C"

Oestrogen-induced apoptosis in colonocytes expressing oestrogen receptor beta by Qiu, Y, Waters, CE, Lewis, AE, Langman, MJ, Eggo, MC

“…Epidemiological studies of postmenopausal hormone replacement therapy show a reduction in the risk of developing colon cancer, and animal studies using…”
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Pituitary Tumor-Transforming Gene Regulates Multiple Downstream Angiogenic Genes in Thyroid Cancer by Kim, D. S., Franklyn, J. A., Stratford, A. L., Boelaert, K., Watkinson, J. C., Eggo, M. C., McCabe, C. J.

“…Context: Pituitary tumor-transforming gene (PTTG) is a multifunctional protein involved in several tumorigenic mechanisms, including angiogenesis. PTTG has…”
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PTTG and PBF repress the human sodium iodide symporter by BOELAERT, K, SMITH, V. E, STRATFORD, A. L, KOGAI, T, TANNAHILL, L. A, WATKINSON, J. C, EGGO, M. C, FRANKLYN, J. A, MCCABE, C. J

“…The ability of the thyroid to accumulate iodide provides the basis for radioiodine ablation of differentiated thyroid cancers and their metastases. Most…”
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Ceiling culture of mature human adipocytes: use in studies of adipocyte functions by Zhang, HH, Kumar, S, Barnett, AH, Eggo, MC

“…Adipocytes contain large lipid droplets in their cytoplasm. When cultured, they float on top of the medium, clump together, and do not gain equal and…”
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Pituitary Tumor Transforming Gene (PTTG) Stimulates Thyroid Cell Proliferation via a Vascular Endothelial Growth Factor/Kinase Insert Domain Receptor/Inhibitor of DNA Binding-3 Autocrine Pathway by Kim, D. S., Franklyn, J. A., Boelaert, K., Eggo, M. C., Watkinson, J. C., McCabe, C. J.

“…Context: Vascular endothelial growth factor (VEGF) exerts its biological effects by binding to the tyrosine kinase receptors VEGF receptor type 1…”
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Impaired detoxication of hydrogen sulfide in ulcerative colitis? by PICTON, R, EGGO, M. C, LANGMAN, M. J. S, SINGH, S

“…Impaired butyrate oxidation and raised counts of sulfate-reducing bacteria in the colon of patients with ulcerative colitis (UC) indicate that the disease may…”
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Antiangiogenic therapy and surgical practice by John, A. R., Bramhall, S. R., Eggo, M. C.

“…Background: Antiangiogenic therapy has become a reality with the recent introduction of bevacizumab, a monoclonal antibody against vascular endothelial growth…”
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Gender differences in the regulation of P450 aromatase expression and activity in human adipose tissue by MCTERNAN, P. G, ANWAR, A, EGGO, M. C, BARNETT, A. H, STEWART, P. M, KUMAR, S

“…To investigate the hormonal regulation of P450 aromatase activity (responsible for the conversion of C19 androgens to C18 oestrogens) in human adipose tissue…”
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Endostatin expression in pancreatic tissue is modulated by elastase by BRAMMER, R. D, BRAMHALL, S. R, EGGO, M. C

“…Pancreatic tumours are scirrhous, avascular tumours, suggesting that they may produce angiogenesis inhibitors that suppress the growth of the vasculature to…”
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Mucosal protection against sulphide: importance of the enzyme rhodanese by Picton, R, Eggo, M C, Merrill, G A, Langman, M J S, Singh, S

“…Background: Hydrogen sulphide (H2S) is a potent toxin normally present in the colonic lumen which may play a role in ulcerative colitis (UC). Two enzymes,…”
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Growth factors and goitrogenesis by Bidey, SP, Hill, DJ, Eggo, MC

“…By combining data from studies of multinodular non-toxic goitre (MNTG) with data from rat models of goitre induction and in vitro models, a map of the growth…”
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Endostatin expression in a pancreatic cell line is modulated by a TNFα-dependent elastase by BRAMMER, R. D, BRAMHALL, S. R, EGGO, M. C

“…Endostatin, an inhibitor of angiogenesis, is a 20 kDa fragment of the basement membrane protein, collagen XVIII. The formation of endostatin relies upon the…”
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Regulation of 11 beta-hydroxysteroid dehydrogenase type 1 in primary cultures of rat and human hepatocytes by Ricketts, ML, Shoesmith, KJ, Hewison, M, Strain, A, Eggo, MC, Stewart, PM

“…Two isozymes of the enzyme 11 beta-hydroxysteroid dehydrogenase (11 beta-HSD) are responsible for the interconversion of the active glucocorticoid, cortisol in…”
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PTTG’s C-terminal PXXP motifs modulate critical cellular processes in vitro by Boelaert, K, Yu, R, Tannahill, L A, Stratford, A L, Khanim, F L, Eggo, M C, Moore, J S, Young, L S, Gittoes, N J L, Franklyn, J A, Melmed, S, McCabe, C J

“…Human pituitary tumor-transforming gene (PTTG), known also as securin, is a multifunctional protein implicated in the control of mitosis and the pathogenesis…”
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Non-steroidal anti-inflammatory drug-induced apoptosis in gastric cancer cells is blocked by protein kinase C activation through inhibition of c-myc by ZHU, G. H, WONG, B. C. Y, EGGO, M. C, CHING, C. K, YUEN, S. T, CHAN, E. Y. T, LAI, K. C, LAM, S. K

“…Apoptosis plays a major role in gastrointestinal epithelial cell turnover, ulcerogenesis and tumorigenesis. We have examined apoptosis induction by…”
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Sulfide-detoxifying enzymes in the human colon are decreased in cancer and upregulated in differentiation by Ramasamy, S, Singh, S, Taniere, P, Langman, M J S, Eggo, M C

“…H2S is highly toxic and selectively inhibits butyrate oxidation in colonocytes. Ineffective detoxification may result in mucosal insult, inflammation, and…”
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Thyroid follicular cells secrete plasminogen activators and can form angiostatin from plasminogen by Ramsden, JD, Yarram, S, Mathews, E, Watkinson, JC, Eggo, MC

“…Angiostatin, a 38 kDa fragment of plasminogen, potently inhibits the growth of blood vessels. Angiostatin is generated from plasminogen by urokinase-type (uPA)…”
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Insulin-like growth factors and their binding proteins in human colonocytes: preferential degradation of insulin-like growth factor binding protein 2 in colonic cancers by MICHELL, N. P, LANGMAN, M. J. S, EGGO, M. C

“…We have compared the expression of insulin-like growth factors (IGFs) and IGF binding proteins (IGFBPs) in ten paired samples of normal and tumour colonic…”
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Sulphide‐induced energy deficiency in colonic cells is prevented by glucose but not by butyrate by Hulin, S. J., Singh, S., Chapman, M. A. S., Allan, A., Langman, M. J. S., Eggo, M. C.

“…Background: In ulcerative colitis, hydrogen sulphide is postulated to impair colonocyte butyrate metabolism, leading to cellular energy deficiency and…”
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Site-specific regulation of oestrogen receptor-α and -β by oestradiol in human adipose tissue by Anwar, A., McTernan, P. G., Anderson, L. A., Askaa, J., Moody, C. G., Barnett, A. H., Eggo, M. C., Kumar, S.

“…SUMMARY Aim  To examine the expression of oestrogen receptors α and β (ERα and ERβ) and their regulation by 17β‐oestradiol (E2) in stromal cells and adipocytes…”
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