Search Results - "Egging, David F."

The Preclinical Profile of the Duocarmycin-Based HER2-Targeting ADC SYD985 Predicts for Clinical Benefit in Low HER2-Expressing Breast Cancers by van der Lee, Miranda M C, Groothuis, Patrick G, Ubink, Ruud, van der Vleuten, Monique A J, van Achterberg, Tanja A, Loosveld, Eline M, Damming, Désirée, Jacobs, Daniëlle C H, Rouwette, Myrthe, Egging, David F, van den Dobbelsteen, Diels, Beusker, Patrick H, Goedings, Peter, Verheijden, Gijs F M, Lemmens, Jacques M, Timmers, Marco, Dokter, Wim H A

“…SYD985 is a HER2-targeting antibody-drug conjugate (ADC) based on trastuzumab and vc-seco-DUBA, a cleavable linker-duocarmycin payload. To evaluate the…”
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A comparison of anti-HER2 IgA and IgG1 in vivo efficacy is facilitated by high N-glycan sialylation of the IgA by Rouwendal, Gerard Ja, van der Lee, Miranda M, Meyer, Saskia, Reiding, Karli R, Schouten, Jan, de Roo, Guy, Egging, David F, Leusen, Jeanette Hw, Boross, Peter, Wuhrer, Manfred, Verheijden, Gijs F, Dokter, Wim H, Timmers, Marco, Ubink, Ruud

“…Monomeric IgA has been proposed as an alternative antibody format for cancer therapy. Here, we present our studies on the production, purification and…”
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Design, Synthesis, and Evaluation of Linker-Duocarmycin Payloads: Toward Selection of HER2-Targeting Antibody–Drug Conjugate SYD985 by Elgersma, Ronald C, Coumans, Ruud G. E, Huijbregts, Tijl, Menge, Wiro M. P. B, Joosten, John A. F, Spijker, Henri J, de Groot, Franciscus M. H, van der Lee, Miranda M. C, Ubink, Ruud, van den Dobbelsteen, Diels J, Egging, David F, Dokter, Wim H. A, Verheijden, Gijs F. M, Lemmens, Jacques M, Timmers, C. Marco, Beusker, Patrick H

“…Antibody–drug conjugates (ADCs) that are currently on the market or in clinical trials are predominantly based on two drug classes: auristatins and…”
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Analysis of obstetric complications and uterine connective tissue in tenascin-X-deficient humans and mice by Egging, David F., van Vlijmen-Willems, Ivonne, Choi, Jiwon, Peeters, Anita C. T. M., van Rens, Desiree, Veit, Guido, Koch, Manuel, Davis, Elaine C., Schalkwijk, Joost

“…Tenascin-X (TNX) is a large, multi-domain, extracellular matrix glycoprotein. Complete deficiency of TNX in humans leads to a recessive form of Ehlers-Danlos…”
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Unraveling the Interaction between Carboxylesterase 1c and the Antibody-Drug Conjugate SYD985: Improved Translational PK/PD by Using Ces1c Knockout Mice by Ubink, Ruud, Dirksen, Eef H C, Rouwette, Myrthe, Bos, Ebo S, Janssen, Ingrid, Egging, David F, Loosveld, Eline M, van Achterberg, Tanja A, Berentsen, Kim, van der Lee, Miranda M C, Bichat, Francis, Raguin, Olivier, van der Vleuten, Monique A J, Groothuis, Patrick G, Dokter, Wim H A

“…Carboxylesterase 1c (CES1c) is responsible for linker-drug instability and poor pharmacokinetics (PK) of several antibody-drug conjugates (ADC) in mice, but…”
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Switching from branded to generic glatiramer acetate: 15-month GATE trial extension results by Selmaj, Krzysztof, Barkhof, Frederik, Belova, Anna N, Wolf, Christian, van den Tweel, Evelyn RW, Oberyé, Janine JL, Mulder, Roel, Egging, David F, Koper, Norbert P, Cohen, Jeffrey A

“…Background: Open-label 15-month follow-up of the double-blind, placebo-controlled Glatiramer Acetate clinical Trial to assess Equivalence with Copaxone® (GATE)…”
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Characterization of low affinity Fc[gamma] receptor biotinylation under controlled reaction conditions by mass spectrometry and ligand binding analysis by Geuijen, Karin PM, Egging, David F, Bartels, Stefanie, Schouten, Jan, Schasfoort, Richard B, Eppink, Michel H

“…Chemical protein biotinylation and streptavidin or anti-biotin-based capture is regularly used for proteins as a more controlled alternative to direct coupling…”
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Characterization of low affinity Fcγ receptor biotinylation under controlled reaction conditions by mass spectrometry and ligand binding analysis by Geuijen, Karin P.M., Egging, David F., Bartels, Stefanie, Schouten, Jan, Schasfoort, Richard B., Eppink, Michel H.

“…Chemical protein biotinylation and streptavidin or anti‐biotin‐based capture is regularly used for proteins as a more controlled alternative to direct coupling…”
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Rapid screening of IgG quality attributes – effects on Fc receptor binding by Geuijen, Karin P. M., Oppers‐Tiemissen, Cindy, Egging, David F., Simons, Peter J., Boon, Louis, Schasfoort, Richard B. M., Eppink, Michel H. M.

“…The interactions of therapeutic antibodies with fragment crystallizable γ (Fcγ) receptors and neonatal Fc receptors (FcRn) are measured in vitro as indicators…”
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Rapid Buffer and Ligand Screening for Affinity Chromatography by Multiplexed Surface Plasmon Resonance Imaging by Geuijen, Karin P. M., van Wijk‐Basten, Daniëlle E. J. W., Egging, David F., Schasfoort, Richard B. M., Eppink, Michel H.

“…Protein purifications are often based on the principle of affinity chromatography, where the protein of interest selectively binds to an immobilized ligand…”
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A comparison of anti-HER2 IgA and IgG1 in vivo efficacy is facilitated by high N-glycan sialylation of the IgA by Rouwendal, Gerard JA, van der Lee, Miranda M, Meyer, Saskia, Reiding, Karli R, Schouten, Jan, de Roo, Guy, Egging, David F, Leusen, Jeanette HW, Boross, Peter, Wuhrer, Manfred, Verheijden, Gijs F, Dokter, Wim H, Timmers, Marco, Ubink, Ruud

“…Monomeric IgA has been proposed as an alternative antibody format for cancer therapy. Here, we present our studies on the production, purification and…”
Get full text