Search Results - "Eggertsen, G."

Muricholic bile acids are potent regulators of bile acid synthesis via a positive feedback mechanism by Hu, X., Bonde, Y., Eggertsen, G., Rudling, M.

“…Objective Bile acid (BA) synthesis is regulated by negative feedback end‐product inhibition, initiated by farnesoid X receptors (FXRs) in liver and gut…”
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Redistribution of lamina-associated domains reshapes binding of pioneer factor FOXA2 in development of nonalcoholic fatty liver disease by Wei, Xiaolong, Murphy, Megan A, Reddy, Nihal A, Hao, Yi, Eggertsen, Taylor G, Saucerman, Jeffrey J, Bochkis, Irina M

“…Nonalcoholic fatty liver disease (NAFLD) is highly prevalent in type 2 diabetes mellitus and the elderly, impacting 40% of individuals over 70. Regulation of…”
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Mice abundant in muricholic bile acids show resistance to dietary induced steatosis, weight gain, and to impaired glucose metabolism by Bonde, Y, Eggertsen, G, Rudling, M

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Unique case of cerebrotendinous xanthomatosis revisited: All the mutations responsible for this disease are present in the CYP27A1 gene by Jiao, H., Olin, M., Hansson, M., Eggertsen, G., Eriksson, M., Angelin, B., Björkhem, I.

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Muricholic bile acids are potent regulators of bile acid synthesis via a positive feedback mechanism (vol 275, pg 27, 2014) by Hu, X, Bonde, Y, Eggertsen, G, Rudling, M

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The thyroid receptor β modulator GC-1 reduces atherosclerosis in ApoE deficient mice by Kannisto, K, Rehnmark, S, Slätis, K, Webb, P, Larsson, L, Gåfvels, M, Eggertsen, G, Parini, P

“…Abstract Thyroid hormone reduces plasma cholesterol and increases expression of low-density lipoprotein receptor (LDL-R) in liver, an effect mediated by…”
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P826 HEPCIDIN LEVELS IN PATIENTS WITH NAFLD WITH OR WITHOUT HYPERFERRITINEMIA AND/OR DYSMETABOLIC IRON OVERLOAD by Marmur, J, Beshara, S, Eggertsen, G, Albiin, N, Danielsson, O, Hultcrantz, R, Stål, P

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LXRβ activation increases intestinal cholesterol absorption, leading to an atherogenic lipoprotein profile by Hu, X., Steffensen, K. R., Jiang, Z.-Y., Parini, P., Gustafsson, J.-Å., Gåfvels, M., Eggertsen, G.

“…  Hu X, Steffensen KR, Jiang Z‐Y, Parini P, Gustafsson J‐Å, Gåfvels M, Eggertsen G (Karolinska Institutet, Huddinge, Stockholm, Sweden; Karolinska Institutet,…”
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Virtual drug screen reveals context-dependent inhibition of cardiomyocyte hypertrophy by Eggertsen, Taylor G, Saucerman, Jeffrey J

“…Pathological cardiomyocyte hypertrophy is a response to cardiac stress that typically leads to heart failure. Despite being a primary contributor to…”
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Studies on LXR- and FXR-mediated effects on cholesterol homeostasis in normal and cholic acid-depleted mice by Wang, J, Einarsson, C, Murphy, C, Parini, P, Björkhem, I, Gåfvels, M, Eggertsen, G

“…As previously reported by us, mice with targeted disruption of the CYP8B1 gene (CYP8B1-/-) fail to produce cholic acid (CA), upregulate their bile acid…”
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Mild iron overload in patients carrying the HFE S65C gene mutation: a retrospective study in patients with suspected iron overload and healthy controls by Holmström, P, Marmur, J, Eggertsen, G, Gåfvels, M, Stål, P

“…Background and aims: The role of the HFE S65C mutation in the development of hepatic iron overload is unknown. The aim of the present study was: (A) to…”
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Benchmarking of protein interaction databases for integration with manually reconstructed signalling network models by Van de Graaf, Matthew W., Eggertsen, Taylor G., Zeigler, Angela C., Tan, Philip M., Saucerman, Jeffrey J.

“…Protein interaction databases are critical resources for network bioinformatics and integrating molecular experimental data. Interaction databases may also…”
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Autosomal recessive hypercholesterolaemia: normalization of plasma LDL cholesterol by ezetimibe in combination with statin treatment by Lind, S., Olsson, A. G., Eriksson, M., Rudling, M., Eggertsen, G., Angelin, B.

“… Background.  Severe hereditary hypercholesterolaemia is most frequently due to familial hypercholesterolaemia (FH), caused by mutations in the LDL receptor…”
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Growth hormone and insulin-like growth factor-1 in acute myocardial infarction by Friberg, L, Werner, S, Eggertsen, G, Ahnve, S

“…Background Growth hormone therapy after myocardial infarction improves cardiac function and survival in animals. Beneficial effects in humans are reported from…”
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Unique patient with cerebrotendinous xanthomatosis. Evidence for presence of a defect in a gene that is not identical to sterol 27‐hydroxylase by Hansson, M., Olin, M., Floren, C.‐H., Von Bahr, S., Van't Hooft, F., Meaney, S., Eggertsen, G., Björkhem, I.

“… Cerebrotendinous xanthomatosis (CTX) is a rare autosomal recessive disorder believed to be exclusively caused by mutations in the CYP27A1 gene coding for the…”
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Genetic characterization of Swedish patients with familial hypercholesterolemia: a heterogeneous pattern of mutations in the LDL receptor gene by Lind, S., Rystedt, E., Eriksson, M., Wiklund, O., Angelin, B., Eggertsen, G.

“…Familial hypercholesterolemia (FH) is an autosomal codominant disease, caused by mutations in the LDL receptor gene. To characterize the distribution of…”
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Regulation of rat hepatic low density lipoprotein receptors. In vivo stimulation by growth hormone is not mediated by insulin-like growth factor I by Rudling, M, Olivecrona, H, Eggertsen, G, Angelin, B

“…Growth hormone (GH) has an important role in the regulation of hepatic LDL receptor expression and plasma lipoprotein levels. This investigation was undertaken…”
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Enrichment of HFE mutations in Swedish patients with familial and sporadic form of porphyria cutanea tarda by Harper, P., Floderus, Y., Holmström, P., Eggertsen, G., Gåfvels, M.

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Markedly Reduced Bile Acid Synthesis but Maintained Levels of Cholesterol and Vitamin D Metabolites in Mice with Disrupted Sterol 27-Hydroxylase Gene by Rosen, Haim, Reshef, Ayeleth, Maeda, Nobuyo, Lippoldt, Andrea, Shpizen, Shoshi, Triger, Liat, Eggertsen, Gösta, Björkhem, Ingemar, Leitersdorf, Eran

“…Sterol 27-hydroxylase is important for the degradation of the steroid side chain in conversion of cholesterol into bile acids and has been ascribed a…”
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Molecular Cloning and Expression of Rabbit Sterol 12α-Hydroxylase by Eggertsen, Gösta, Olin, Maria, Andersson, Ulla, Ishida, Hiroko, Kubota, Shunichiro, Hellman, Ulf, Okuda, Kyu-Ichiro, Björkhem, Ingemar

“…Sterol 12α-hydroxylase is an important enzyme in bile acid biosynthesis, responsible for the balance between formation of cholic acid and chenodeoxycholic…”
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