Search Results - "Eger, Edmond I."

Is Synergy the Rule? A Review of Anesthetic Interactions Producing Hypnosis and Immobility by Hendrickx, Jan F. A., Eger, Edmond I, Sonner, James M., Shafer, Steven L.

“…Drug interactions may reveal mechanisms of drug action: additive interactions suggest a common site of action, and synergistic interactions suggest different…”
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Age, Minimum Alveolar Anesthetic Concentration, and Minimum Alveolar Anesthetic Concentration-Awake by Eger, Edmond I

“…Two defining effects of inhaled anesthetics (immobility in the face of noxious stimulation, and absence of memory) correlate with the end-tidal concentrations…”
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Inhaled Anesthetics and Immobility: Mechanisms, Mysteries, and Minimum Alveolar Anesthetic Concentration by Sonner, James M., Antognini, Joseph F., Dutton, Robert C., Flood, Pamela, Gray, Andrew T., Harris, R. Adron, Homanics, Gregg E., Kendig, Joan, Orser, Beverley, Raines, Douglas E., Trudell, James, Vissel, Bryce, Eger, Edmond I

“…Studies using molecular modeling, genetic engineering, neurophysiology/pharmacology, and whole animals have advanced our understanding of where and how inhaled…”
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Three Memorable Years by Eger, Edmond I

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Maybe it isn't aging by Eger, 2nd, Edmond I

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Differential Modulation of Human N-Methyl-d-Aspartate Receptors by Structurally Diverse General Anesthetics by Solt, Ken, Eger, Edmond I, Raines, Douglas E.

“…N-Methyl-d-aspartate (NMDA) receptors have a presumed role in excitatory synaptic transmission and nociceptive pathways. Although previous studies have found…”
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Isoflurane Suppresses Stress-enhanced Fear Learning in a Rodent Model of Post-Traumatic Stress Disorder by RAU, Vinuta, OH, Irene, LASTER, Michael, EGER, Edmond I, FANSELOW, Michael S

“…A minority of patients who experience awareness and/or pain during surgery subsequently develop post-traumatic stress disorder. In a rodent model of…”
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Characteristics of anesthetic agents used for induction and maintenance of general anesthesia by Eger, 2nd, Edmond I

“…The characteristics of ideal intravenous (i.v.) and inhaled anesthetic agents; the rationale for inducing anesthesia with i.v. anesthetics (particularly…”
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From the Journal archives: A harbinger of modern anesthesia by Eger, Edmond I.

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Conserved role of unc-79 in ethanol responses in lightweight mutant mice by Speca, David J, Chihara, Daisuke, Ashique, Amir M, Bowers, M Scott, Pierce-Shimomura, Jonathan T, Lee, Jungsoo, Rabbee, Nusrat, Speed, Terence P, Gularte, Rodrigo J, Chitwood, James, Medrano, Juan F, Liao, Mark, Sonner, James M, Eger, 2nd, Edmond I, Peterson, Andrew S, McIntire, Steven L

“…The mechanisms by which ethanol and inhaled anesthetics influence the nervous system are poorly understood. Here we describe the positional cloning and…”
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Is a New Paradigm Needed to Explain How Inhaled Anesthetics Produce Immobility? by Eger, Edmond I, Raines, Douglas E., Shafer, Steven L., Hemmings, Hugh C., Sonner, James M.

“…A paradox arises from present information concerning the mechanism(s) by which inhaled anesthetics produce immobility in the face of noxious stimulation…”
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Tutorial: Context-Sensitive Decrement Times for Inhaled Anesthetics by Eger, Edmond I, Shafer, Steven L.

“…Context-sensitive decrement times for inhaled anesthetics connect two valuesa) the duration of anesthesia (nominally at a constant alveolar concentration)—the…”
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A Different Perspective on Anesthetics and Climate Change by Mychaskiw, George, Eger, Edmond I

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Slowing of the Hippocampal θ Rhythm Correlates with Anesthetic-induced Amnesia by PEROUANSKY, Misha, RAU, Vinuta, FORD, Tim, OH, S. Irene, PERKINS, Mark, EGER, Edmond I, PEARCE, Robert A

“…Temporary, antegrade amnesia is one of the core desirable endpoints of general anesthesia. Multiple lines of evidence support a role for the hippocampal θ…”
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Illustrations of Inhaled Anesthetic Uptake, Including Intertissue Diffusion to and from Fat by Eger, Edmond I., Saidman, Lawrence J.

“…Although several mathematical and computer simulations of inhaled anesthetic pharmacokinetics have been devised, their complexity sometimes limits an intuitive…”
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After you, please: the second Annual John W. Severinghaus Lecture on Translational Science by Eger, 2nd, Edmond I

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Alzheimer's disease and anesthesia: Out of body, out of mind...or not? by Harris, R. Adron, Eger II, Edmond I.

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Gamma-Aminobutyric Acid Type A Receptor β3 Subunit Forebrain-Specific Knockout Mice Are Resistant to the Amnestic Effect of Isoflurane by Rau, Vinuta, Oh, Irene, Liao, Mark, Bodarky, Christina, Fanselow, Michael S., Homanics, Gregg E., Sonner, James M., Eger, Edmond I

“…β3 containing γ-aminobutyric acid type A receptors (GABA(A)-Rs) mediate behavioral end points of IV anesthetics such as immobility and hypnosis. A knockout…”
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The Effects of Volatile Aromatic Anesthetics on Voltage-Gated Na+ Channels Expressed in Xenopus Oocytes by Horishita, Takafumi, Eger, Edmond I., Harris, R Adron

“…Many inhaled anesthetics inhibit voltage-gated sodium channels at clinically relevant concentrations, and suppression of neurotransmitter release by these…”
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Ross C. Terrell, PhD, an Anesthetic Pioneer by Burns, William Burns, Eger, Edmond I

“…On December 30, 2010, Ross C. Terrell, PhD, died. With his passing at age 85, we lost one of the pioneers of modern anesthesia. Terrell synthesized most of the…”
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