Search Results - "Egelman, E H"

Structural Plasticity of Helical Nanotubes Based on Coiled-Coil Assemblies by Egelman, E.H., Xu, C., DiMaio, F., Magnotti, E., Modlin, C., Yu, X., Wright, E., Baker, D., Conticello, V.P.

“…Numerous instances can be seen in evolution in which protein quaternary structures have diverged while the sequences of the building blocks have remained…”
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A conformational change in the actin subunit can change the flexibility of the actin filament by Orlova, A, Egelman, E H

“…The mechanical properties of F-actin are very significant, given the central structural role played by actin filaments within muscle and the cytoskeleton. We…”
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Cofilin Cross-bridges Adjacent Actin Protomers and Replaces part of the Longitudinal F-actin Interface by Kudryashov, D.S., Galkin, V.E., Orlova, A., Phan, M., Egelman, E.H., Reisler, E.

“…ADF/cofilins are abundant actin binding proteins critical to the survival of eukaryotic cells. Most ADF/cofilins bind both G and F-actin, sever the filaments…”
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Similarity of the yeast RAD51 filament to the bacterial RecA filament by Ogawa, T. (Osaka University Osaka, Japan), Yu, X, Shinohara, A, Egelman, E.H

“…The RAD51 protein functions in the processes of DNA repair and in mitotic and meiotic genetic recombination in the yeast Saccharomyces cerevisiae. The protein…”
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Actin allostery again? by Egelman, Edward H

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Bacteriophage T7 Helicase/Primase Proteins Form Rings Around Single-Stranded DNA that Suggest a General Structure for Hexameric Helicases by Egelman, Edward H., Yu, Xiong, Wild, Robert, Hingorani, Manju M., Patel, Smita S.

“…Most helicases studied to date have been characterized as oligomeric, but the relation between their structure and function has not been understood. The…”
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The twist, writhe and overall shape of supercoiled DNA change during counterion-induced transition from a loosely to a tightly interwound superhelix. Possible implications for DNA structure in vivo by Bednar, J, Furrer, P, Stasiak, A, Dubochet, J, Egelman, E H, Bates, A D

“…A cryo-electron microscopy study of supercoiled DNA molecules freely suspended in cryo-vitrified buffer was combined with Monte Carlo simulations and gel…”
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Structural basis for the destabilization of F-actin by phosphate release following ATP hydrolysis by Orlova, A, Egelman, E H

“…The role of ATP hydrolysis in actin polymerization has been a puzzle, since it is known that polymer formation is possible without the ATPase activity and that…”
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A robust algorithm for the reconstruction of helical filaments using single-particle methods by Egelman, Edward H.

“…Some of the earliest methods for three-dimensional reconstruction from electron microscopic images were developed for helical objects. Single-particle methods…”
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DNA is bound within the central hole to one or two of the six subunits of the T7 DNA helicase by Yu, Xiong, Hingorani, Manju M, Patel, Smita S, Egelman, Edward H

“…Electron microscopic image analysis and protein-DNA crosslinking show that DNA binds asymmetrically to the hexameric bacteriophage T7 gp4b helicase, and binds…”
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Structural data suggest that the active and inactive forms of the RecA filament are not simply interconvertible by Yu, X, Egelman, E H

“…We have used electron microscopy to examine the two major conformational states of the helical filament formed by the RecA protein of Escherichia coli. The…”
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What is the structure of the RecA-DNA filament? by Yu, X, VanLoock, M S, Yang, S, Reese, J T, Egelman, E H

“…The bacterial RecA protein has been a model system for understanding how a protein can catalyze homologous genetic recombination. RecA-like proteins have now…”
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The Location of DNA in RecA-DNA Helical Filaments by Egelman, E. H., Yu, X.

“…The helical filament that the RecA protein of Escherichia coli forms around DNA is the active apparatus in protein-catalyzed homologous genetic recombination…”
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The Escherichia coli RuvB Branch Migration Protein Forms Double Hexameric Rings Around DNA by Stasiak, A, Tsaneva, I R, West, S C, Benson, C J, Yu, X, Egelman, E H

“…The RuvB protein is induced in Escherichia coli as part of the SOS response to DNA damage. It is required for genetic recombination and the postreplication…”
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The Sendai virus nucleocapsid exists in at least four different helical states by EGELMAN, E. H, WU, S.-S, AMREIN, M, PORTNER, A, MURIT, G

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Rad51 and Rad54 ATPase activities are both required to modulate Rad51-dsDNA filament dynamics by Li, Xuan, Zhang, Xiao-Ping, Solinger, Jachen A, Kiianitsa, Konstantin, Yu, Xiong, Egelman, Edward H, Heyer, Wolf-Dietrich

“…Rad51 and Rad54 are key proteins that collaborate during homologous recombination. Rad51 forms a presynaptic filament with ATP and ssDNA active in homology…”
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The LexA repressor binds within the deep helical groove of the activated RecA filament by Yu, X, Egelman, E H

“…The RecA protein of Escherichia coli, as a result of DNA damage, catalyzes the cleavage of its own repressor, the LexA protein, and thereby initiates the SOS…”
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Structure of helical RecA-DNA complexes. Complexes formed in the presence of ATP-gamma-S or ATP by Egelman, E H, Stasiak, A

“…Electron micrographs of RecA-DNA filaments, formed under several different conditions, have been analyzed and the filament images reconstructed in three…”
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The Bipolar Filaments Formed by Herpes Simplex Virus Type 1 SSB/Recombination Protein (ICP8) Suggest a Mechanism for DNA Annealing by Makhov, Alexander M., Sen, Anindito, Yu, Xiong, Simon, Martha N., Griffith, Jack D., Egelman, Edward H.

“…Herpes simplex virus type 1 encodes a multifunctional protein, ICP8, which serves both as a single-strand binding protein and as a recombinase, catalyzing…”
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The RecA hexamer is a structural homologue of ring helicases by Yu, Xiong, Egelman, Edward H

“…The RecA protein forms a hexameric ring that is similar to the core of the F1-ATPase. Several lines of evidence suggest that this hexamer may be a structural…”
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