Search Results - "Egan, Sean E."

RB1 deficiency in triple-negative breast cancer induces mitochondrial protein translation by Jones, Robert A, Robinson, Tyler J, Liu, Jeff C, Shrestha, Mariusz, Voisin, Veronique, Ju, YoungJun, Chung, Philip E D, Pellecchia, Giovanna, Fell, Victoria L, Bae, SooIn, Muthuswamy, Lakshmi, Datti, Alessandro, Egan, Sean E, Jiang, Zhe, Leone, Gustavo, Bader, Gary D, Schimmer, Aaron, Zacksenhaus, Eldad

“…Triple-negative breast cancer (TNBC) includes basal-like and claudin-low subtypes for which no specific treatment is currently available. Although the…”
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Manic fringe promotes a claudin-low breast cancer phenotype through notch-mediated PIK3CG induction by Zhang, Shubing, Chung, Wen-Cheng, Wu, Guanming, Egan, Sean E, Miele, Lucio, Xu, Keli

“…Claudin-low breast cancer (CLBC) is a poor prognosis disease biologically characterized by stemness and mesenchymal features. These tumors disproportionately…”
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Elevated expression of wildtype RhoC promotes ErbB2- and Pik3ca-induced mammary tumor formation by Raghuram, Nandini, Temel, E Idil, Kawamata, Toshihiro, Kozma, Katelyn J, Loch, Amanda J, Wang, Wei, Adams, Jessica R, Muller, William J, Egan, Sean E

“…Copy number gains in genes coding for Rho activating exchange factors as well as losses affecting genes coding for RhoGAP proteins are common in breast…”
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The tumor cell‐derived matrix of lobular breast cancer: a new vulnerability by Kozma, Katelyn J, Done, Susan J, Egan, Sean E

“…Invasive lobular carcinoma (ILC) of the breast is a very common disease. Despite its prevalence, these tumors are relatively understudied. One reason for this…”
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RB1 status in triple negative breast cancer cells dictates response to radiation treatment and selective therapeutic drugs by Robinson, Tyler J W, Liu, Jeff C, Vizeacoumar, Frederick, Sun, Thomas, Maclean, Neil, Egan, Sean E, Schimmer, Aaron D, Datti, Alessandro, Zacksenhaus, Eldad

“…Triple negative breast cancer (TNBC) includes basal-like and claudin-low subtypes for which only chemotherapy and radiation therapy are currently available…”
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Identification of CDC25 as a Common Therapeutic Target for Triple-Negative Breast Cancer by Liu, Jeff C., Granieri, Letizia, Shrestha, Mariusz, Wang, Dong-Yu, Vorobieva, Ioulia, Rubie, Elizabeth A., Jones, Rob, Ju, YoungJun, Pellecchia, Giovanna, Jiang, Zhe, Palmerini, Carlo A., Ben-David, Yaacov, Egan, Sean E., Woodgett, James R., Bader, Gary D., Datti, Alessandro, Zacksenhaus, Eldad

“…CDK4/6 inhibitors are effective against cancer cells expressing the tumor suppressor RB1, but not RB1-deficient cells, posing the challenge of how to target…”
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Distinct shared and compartment-enriched oncogenic networks drive primary versus metastatic breast cancer by Jiang, Zhe, Ju, YoungJun, Ali, Amjad, Chung, Philip E. D., Skowron, Patryk, Wang, Dong-Yu, Shrestha, Mariusz, Li, Huiqin, Liu, Jeff C., Vorobieva, Ioulia, Ghanbari-Azarnier, Ronak, Mwewa, Ethel, Koritzinsky, Marianne, Ben-David, Yaacov, Woodgett, James R., Perou, Charles M., Dupuy, Adam, Bader, Gary D., Egan, Sean E., Taylor, Michael D., Zacksenhaus, Eldad

“…Metastatic breast-cancer is a major cause of death in women worldwide, yet the relationship between oncogenic drivers that promote metastatic versus primary…”
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Lunatic Fringe Deficiency Cooperates with the Met/Caveolin Gene Amplicon to Induce Basal-like Breast Cancer by Xu, Keli, Usary, Jerry, Kousis, Philaretos C., Prat, Aleix, Wang, Dong-Yu, Adams, Jessica R., Wang, Wei, Loch, Amanda J., Deng, Tao, Zhao, Wei, Cardiff, Robert Darrell, Yoon, Keejung, Gaiano, Nicholas, Ling, Vicki, Beyene, Joseph, Zacksenhaus, Eldad, Gridley, Tom, Leong, Wey L., Guidos, Cynthia J., Perou, Charles M., Egan, Sean E.

“…Basal-like breast cancers (BLBC) express a luminal progenitor gene signature. Notch receptor signaling promotes luminal cell fate specification in the mammary…”
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Combined deletion of Pten and p53 in mammary epithelium accelerates triple‐negative breast cancer with dependency on eEF2K by Liu, Jeff C, Voisin, Veronique, Wang, Sharon, Wang, Dong‐Yu, Jones, Robert A, Datti, Alessandro, Uehling, David, Al‐awar, Rima, Egan, Sean E, Bader, Gary D, Tsao, Ming, Mak, Tak W, Zacksenhaus, Eldad

“…The tumor suppressors Pten and p53 are frequently lost in breast cancer, yet the consequences of their combined inactivation are poorly understood. Here, we…”
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Cooperation between Pik3ca and p53 Mutations in Mouse Mammary Tumor Formation by ADAMS, Jessica R, KELI XU, EGAN, Sean E, LIU, Jeff C, RUIZ AGAMEZ, Natalia M, LOCH, Amanda J, WONG, Ruth G, WEI WANG, WRIGHT, Katherine L, LANE, Timothy F, ZACKSENHAUS, Eldad

“…PIK3CA, which codes for the p110α catalytic subunit of phosphatidylinositol 3-kinase, is one of the most frequently mutated genes in human breast cancer. Here,…”
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Cdh1 and Pik3ca Mutations Cooperate to Induce Immune-Related Invasive Lobular Carcinoma of the Breast by An, Yeji, Adams, Jessica R., Hollern, Daniel P., Zhao, Anthony, Chang, Stephen G., Gams, Miki S., Chung, Philip E.D., He, Xiaping, Jangra, Rhea, Shah, Juhi S., Yang, Joanna, Beck, Lauren A., Raghuram, Nandini, Kozma, Katelyn J., Loch, Amanda J., Wang, Wei, Fan, Cheng, Done, Susan J., Zacksenhaus, Eldad, Guidos, Cynthia J., Perou, Charles M., Egan, Sean E.

“…CDH1 and PIK3CA are the two most frequently mutated genes in invasive lobular carcinoma (ILC) of the breast. Transcription profiling has identified molecular…”
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Jagged1 is the major regulator of notch‐dependent cell fate in proximal airways by Zhang, Shubing, Loch, Amanda J., Radtke, Freddy, Egan, Sean E., Xu, Keli

“…ABSTRACT Background: The Notch signaling pathway plays complex roles in developing lungs, including regulation of proximodistal fates, airway cell…”
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Seventeen-gene signature from enriched Her2/Neu mammary tumor-initiating cells predicts clinical outcome for human HER2⁺:ERα⁻ breast cancer by Liu, Jeff C., Voisin, Veronique, Bader, Gary D., Deng, Tao, Pusztai, Lajos, Symmans, William Fraser, Esteva, Francisco J., Egan, Sean E., Zacksenhaus, Eldad

“…Human Epidermal Growth Factor Receptor 2-positive (HER2⁺) breast cancer (BC) is a highly aggressive disease commonly treated with chemotherapy and anti-HER2…”
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Lunatic and Manic Fringe Cooperatively Enhance Marginal Zone B Cell Precursor Competition for Delta-like 1 in Splenic Endothelial Niches by Tan, Joanne B., Xu, Keli, Cretegny, Kira, Visan, Ioana, Yuan, Julie S., Egan, Sean E., Guidos, Cynthia J.

“…Notch2 activation induced by Delta-like-1 (DL1) drives development of splenic marginal zone (MZ) B cells, an innate-like lineage that protects against sepsis…”
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High-level JAG1 mRNA and protein predict poor outcome in breast cancer by Dickson, Brendan C, Mulligan, Anna Marie, Zhang, Hui, Lockwood, Gina, O'Malley, Frances P, Egan, Sean E, Reedijk, Michael

“…Notch receptors regulate cell fate determination, stem cell self-renewal, proliferation and apoptosis. We previously reported that elevated mRNA expression of…”
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RB1 and p53 at the crossroad of EMT and triple-negative breast cancer by Jiang, Zhe, Jones, Robert, Liu, Jeff C., Deng, Tao, Robinson, Tyler, Chung, Philip E.D., Wang, Sharon, Herschkowitz, Jason I., Egan, Sean E., Perou, Charles M., Zacksenhaus, Eldad

“…Triple-negative breast cancer (TNBC) is a heterogeneous disease that includes Basal-like and Claudin-low tumors. The Claudin-low tumors are enriched for…”
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STAT3 promotes survival of mutant photoreceptors in inherited photoreceptor degeneration models by Jiang, Ke, Wright, Katherine L, Zhu, Ping, Szego, Michael J, Bramall, Alexa N, Hauswirth, William W, Li, Qiuhong, Egan, Sean E, McInnes, Roderick R

“…Inherited photoreceptor degenerations (IPDs), a group of incurable progressive blinding diseases, are caused by mutations in more than 200 genes, but little is…”
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Single allele loss-of-function mutations select and sculpt conditional cooperative networks in breast cancer by Schachter, Nathan F., Adams, Jessica R., Skowron, Patryk, Kozma, Katelyn. J., Lee, Christian A., Raghuram, Nandini, Yang, Joanna, Loch, Amanda J., Wang, Wei, Kucharczuk, Aaron, Wright, Katherine L., Quintana, Rita M., An, Yeji, Dotzko, Daniel, Gorman, Jennifer L., Wojtal, Daria, Shah, Juhi S., Leon-Gomez, Paul, Pellecchia, Giovanna, Dupuy, Adam J., Perou, Charles M., Ben-Porath, Ittai, Karni, Rotem, Zacksenhaus, Eldad, Woodgett, Jim R., Done, Susan J., Garzia, Livia, Sorana Morrissy, A., Reimand, Jüri, Taylor, Michael D., Egan, Sean E.

“…The most common events in breast cancer (BC) involve chromosome arm losses and gains. Here we describe identification of 1089 gene-centric common insertion…”
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Tumor-Suppressive Activity of Lunatic Fringe in Prostate through Differential Modulation of Notch Receptor Activation by Zhang, Shubing, Chung, Wen-cheng, Wu, Guanming, Egan, Sean E, Xu, Keli

“…Abstract Elevated Notch ligand and receptor expression has been associated with aggressive forms of prostate cancer, suggesting a role for Notch signaling in…”
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Transcriptomic classification of genetically engineered mouse models of breast cancer identifies human subtype counterparts by Pfefferle, Adam D, Herschkowitz, Jason I, Usary, Jerry, Chuck Harrell, Joshua, Spike, Benjamin T, Adams, Jessica R, Torres-Arzayus, Maria I, Brown, Myles, Egan, Sean E, Wahl, Geoffrey M, Rosen, Jeffrey M, Perou, Charles M

“…BACKGROUND: Human breast cancer is a heterogeneous disease consisting of multiple molecular subtypes. Genetically engineered mouse models are a useful resource…”
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