Search Results - "Egan, Josephine"

Physiological Integration of Taste and Metabolism by Egan, Josephine M.

“…Much of what we learned in school about how we taste is wrong. Progress in understanding how taste works is providing insights that may help in the management…”
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Age-Related Changes in Glucose Metabolism, Hyperglycemia, and Cardiovascular Risk by Chia, Chee W, Egan, Josephine M, Ferrucci, Luigi

“…Aging and diabetes mellitus are 2 well-known risk factors for cardiovascular disease (CVD). During the past 50 years, there has been an dramatic increase in…”
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The Role of Incretins in Glucose Homeostasis and Diabetes Treatment by Kim, Wook, Egan, Josephine M

“…Incretins are gut hormones that are secreted from enteroendocrine cells into the blood within minutes after eating. One of their many physiological roles is to…”
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Incretins in obesity and diabetes by Chia, Chee W., Egan, Josephine M.

“…Incretins are hormones secreted from enteroendocrine cells after nutrient intake that stimulate insulin secretion from β cells in a glucose‐dependent manner…”
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Resveratrol and curcumin enhance pancreatic β-cell function by inhibiting phosphodiesterase activity by Rouse, Michael, Younès, Antoine, Egan, Josephine M

“…Resveratrol (RES) and curcumin (CUR) are polyphenols that are found in fruits and turmeric, and possess medicinal properties that are beneficial in various…”
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Evidence for brain glucose dysregulation in Alzheimer's disease by An, Yang, Varma, Vijay R., Varma, Sudhir, Casanova, Ramon, Dammer, Eric, Pletnikova, Olga, Chia, Chee W., Egan, Josephine M., Ferrucci, Luigi, Troncoso, Juan, Levey, Allan I., Lah, James, Seyfried, Nicholas T., Legido-Quigley, Cristina, O'Brien, Richard, Thambisetty, Madhav

“…It is unclear whether abnormalities in brain glucose homeostasis are associated with Alzheimer's disease (AD) pathogenesis. Within the autopsy cohort of the…”
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Medium Chain Triglycerides induce mild ketosis and may improve cognition in Alzheimer’s disease. A systematic review and meta-analysis of human studies by Avgerinos, Konstantinos I., Egan, Josephine M., Mattson, Mark P., Kapogiannis, Dimitrios

“…•Meta-analysis of RCTs showed that administration of oral medium chain triglycerides induced mild ketosis in AD.•Meta-analysis of RCTs showed that oral medium…”
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Diabetes and Altered Glucose Metabolism with Aging by Kalyani, Rita Rastogi, MD, MHS, Egan, Josephine M., MD

“…Diabetes and impaired glucose tolerance affect a substantial proportion of older adults. Abnormal glucose metabolism is not a necessary component of aging…”
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Denatonium induces secretion of glucagon-like peptide-1 through activation of bitter taste receptor pathways by Kim, Ki-Suk, Egan, Josephine M., Jang, Hyeung-Jin

“…Aims/hypothesis This study was designed to ascertain whether human enteroendocrine cells express bitter taste receptors, and whether activation of these…”
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Circulating brain-derived neurotrophic factor and indices of metabolic and cardiovascular health: data from the Baltimore Longitudinal Study of Aging by Golden, Erin, Emiliano, Ana, Maudsley, Stuart, Windham, B Gwen, Carlson, Olga D, Egan, Josephine M, Driscoll, Ira, Ferrucci, Luigi, Martin, Bronwen, Mattson, Mark P

“…Besides its well-established role in nerve cell survival and adaptive plasticity, brain-derived neurotrophic factor (BDNF) is also involved in energy…”
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1513-P: IAPP25 in Beta Cells and DNSP11 in Alpha Cells Inhibit IAPP37 Fibrillation by LIU, QING-RONG, ZHU, MIN, EGAN, JOSEPHINE M.

“…Amyloidosis due to aggregation of mature islet amyloid polypeptide (IAPP37) in human islets causes β-cell dysfunction and there is a need to develop…”
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Mechanisms of action of glucagon-like peptide 1 in the pancreas by Doyle, Máire E, Egan, Josephine M

“…Glucagon-like peptide 1 (GLP-1) is a hormone that is encoded in the proglucagon gene. It is mainly produced in enteroendocrine L cells of the gut and is…”
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Human Type II Taste Cells Express Angiotensin-Converting Enzyme 2 and Are Infected by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) by Doyle, Máire E., Appleton, Ashley, Liu, Qing-Rong, Yao, Qin, Mazucanti, Caio H., Egan, Josephine M.

“…Chemosensory changes are well-reported symptoms of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. The virus targets cells for entry by…”
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Targeting Stem Cells in Chronic Myeloid Leukemia with a PPAR-γ Agonist by Egan, Josephine M

“…Combining a tyrosine kinase inhibitor (imatinib) and a thiazolidinedione (pioglitazone) is proposed for the treatment of chronic myeloid leukemia. Chronic…”
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Chronic Low-Calorie Sweetener Use and Risk of Abdominal Obesity among Older Adults: A Cohort Study by Chia, Chee W, Shardell, Michelle, Tanaka, Toshiko, Liu, David D, Gravenstein, Kristofer S, Simonsick, Eleanor M, Egan, Josephine M, Ferrucci, Luigi

“…Low-calorie sweetener use for weight control has come under increasing scrutiny as obesity, especially abdominal obesity, remain entrenched despite substantial…”
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1304-P: Quantification of Preproinsulin and Insulin Isoforms Derived from Upstream Open Reading Frames in Human Clinical Samples by Selected Reaction Monitoring Assay by LIU, QING-RONG, ZHU, MIN, GHOSH, PARITOSH, CHIA, CHEE W., EGAN, JOSEPHINE M.

“…We recently uncovered a novel human proinsulin containing a amino-acid Cα-peptide and upstream open reading frame (uORF) isoforms whose transcription is…”
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Incretin-Based Therapies in Type 2 Diabetes Mellitus by Chia, Chee W., Egan, Josephine M.

“…Context: Glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide are incretins secreted from enteroendocrine cells postprandially in…”
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Pancreatic β cell derived extracellular vesicles containing surface preproinsulin are involved in glucose stimulated insulin secretion by Ghosh, Paritosh, Liu, Qing-Rong, Chen, Qinghua, Zhu, Min, Egan, Josephine M.

“…Extracellular vesicles (EVs) are involved in intercellular communication and are a topic of increasing interest due to their therapeutic potential. The aim of…”
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1895-P: The Role of Endocannabinoid Receptor 1 (CB1R) in the Insulin Signaling Pathway by KIM, YOO, EGAN, JOSEPHINE M.

“…Cannabinoid 1 receptors (CB1Rs) are G protein-coupled receptors that are present in peripheral organs such as liver, pancreas, adipose tissue and skeletal…”
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The physiology of endocrine systems with ageing by van den Beld, Annewieke W, Kaufman, Jean-Marc, Zillikens, M Carola, Lamberts, Steven W J, Egan, Josephine M, van der Lely, Aart J

“…During ageing, the secretory patterns of the hormones produced by the hypothalamic–pituitary axis change, as does the sensitivity of the axis to negative…”
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