Search Results - "Egan, J B"

Genome-wide studies in multiple myeloma identify XPO1/CRM1 as a critical target validated using the selective nuclear export inhibitor KPT-276 by Schmidt, J, Braggio, E, Kortuem, K M, Egan, J B, Zhu, Y X, Xin, C S, Tiedemann, R E, Palmer, S E, Garbitt, V M, McCauley, D, Kauffman, M, Shacham, S, Chesi, M, Bergsagel, P L, Stewart, A K

“…RNA interference screening identified XPO1 (exportin 1) among the 55 most vulnerable targets in multiple myeloma (MM). XPO1 encodes CRM1, a nuclear export…”
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Longitudinal analysis of 25 sequential sample-pairs using a custom multiple myeloma mutation sequencing panel (M3P) by Kortüm, K. M., Langer, C., Monge, J., Bruins, L., Zhu, Y. X., Shi, C. X., Jedlowski, P., Egan, J. B., Ojha, J., Bullinger, L., Kull, M., Ahmann, G., Rasche, L., Knop, S, Fonseca, R., Einsele, H., Stewart, A. K., Braggio, Esteban

“…Recent advances in genomic sequencing technologies now allow results from deep next-generation sequencing to be obtained within clinically meaningful…”
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Association between polymorphic variation in VDR and RXRA and circulating levels of vitamin D metabolites by Hibler, E.A., Jurutka, P.W., Egan, J.B., Hu, C., LeRoy, E.C., Martinez, M.E., Thompson, P.A., Jacobs, E.T.

“…The vitamin D metabolite 1,25(OH) 2D is the bioactive ligand of the vitamin D receptor (VDR). VDR forms a heterodimer with the retinoid X receptors (RXRs) that…”
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Lessons from next-generation sequencing analysis in hematological malignancies by Braggio, E, Egan, J B, Fonseca, R, Stewart, A K

“…Next-generation sequencing has led to a revolution in the study of hematological malignancies with a substantial number of publications and discoveries in the…”
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Improved detection of helix-turn-helix DNA-binding motifs in protein sequences by DODD, I. B, EGAN, J. B

“…We present an update of our method for systematic detection and evaluation of potential helix-turn-helix DNA-binding motifs in protein sequences [Dodd, I. and…”
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Transcriptional interference – a crash course by Shearwin, Keith E., Callen, Benjamin P., Egan, J. Barry

“…The term ‘transcriptional interference’ (TI) is widely used but poorly defined in the literature. There are a variety of methods by which one can interfere…”
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Establishment of lysogeny in bacteriophage 186. DNA binding and transcriptional activation by the CII protein by Shearwin, K E, Egan, J B

“…The CII protein of bacteriophage 186 is a transcriptional activator of the helix-turn helix family required for establishment of the lysogenic state. DNA…”
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Neuraxial blockade and patient risk by Egan, B J, Brown, A R

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The integrase family of site‐specific recombinases: regional similarities and global diversity by Argos, P., Landy, A., Abremski, K., Egan, J.B., Haggard‐Ljungquist, E., Hoess, R.H., Kahn, M.L., Kalionis, B., Narayana, S.V., Pierson, L.S.

“…A combination of two methods for detecting distant relationships in protein primary sequences was used to compare the site‐specific recombination proteins…”
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Treatment of Helicobacter pylori by Egan, B. J., Katicic, M., O'Connor, H. J., O'Morain, C. A.

“…Since the discovery of Helicobacter pylori in the early 1980s many treatment regimes have been developed to effectively treat this infection. International…”
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Cooperativity in long-range gene regulation by the lambda CI repressor by Dodd, Ian B, Shearwin, Keith E, Perkins, Alison J, Burr, Tom, Hochschild, Ann, Egan, J Barry

“…Effective repression of cI transcription from PRM by the bacteriophage lambda CI repressor requires binding sites (OL) located 2.4 kb from the promoter. A CI…”
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Transcriptional Interference between Convergent Promoters Caused by Elongation over the Promoter by Callen, Benjamin P, Shearwin, Keith E, Egan, J.Barry

“…Transcriptional interference with convergent transcription from face-to-face promoters is a potentially important form of gene regulation in all organisms…”
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Establishing Lysogenic Transcription in the Temperate Coliphage 186 by Neufing, P J, Shearwin, K E, Egan, J B

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Metal‐ and DNA‐binding properties and mutational analysis of the transcription activating factor, B, of coliphage 186: A prokaryotic C4 zinc‐finger protein by Pountney, Dean L., Tiwari, Ravi P., Egan, J. Barry

“…Coliphage 186 B is a 72‐amino acid protein belonging to the Ogr family of analogous transcription factors present in P2‐like phage, which contain a…”
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Genes for the establishment and maintenance of lysogeny by the temperate coliphage 186 by LAMONT, I, RICHARDSON, H, CARTER, D. R, EGAN, J. B

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UV Induction of Coliphage 186: Prophage Induction as an SOS Function by Lamont, Iain, Brumby, Anthony M., Egan, J. Barry

“…Our results show that UV induction of the 186 prophage depends upon the phage function Tum, with the mutant phenotype of turbid plaques on mitomycin plates and…”
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A Mathematical Model for Transcriptional Interference by RNA Polymerase Traffic in Escherichia coli by Sneppen, Kim, Dodd, Ian B., Shearwin, Keith E., Palmer, Adam C., Schubert, Rachel A., Callen, Benjamin P., Egan, J. Barry

“…Interactions between RNA polymerases (RNAP) resulting from tandem or convergent arrangements of promoters can cause transcriptional interference, often with…”
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DNA replication studies with coliphage 186: the involvement of the Escherichia coli DnaA protein in 186 replication is indirect by Williams, S G, Egan, J B

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What is new in the management of Helicobacter pylori? by Egan, B. J., O’Connor, H. J., O’Morain, C. A.

“…Since the discovery of Helicobacter pylori in the early 1980s several treatment regimens have been developed to effectively treat this infection. International…”
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Double torsion fracture testing of high-density polyethylene by EGAN, B. J, DELATYCKI, O

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