Interaction between phospholipid monolayer and volatile anesthetics using quartz crystal oscillator methods

The interaction between phospholipid monolayer (dihexadecyl phosphate: DHP) and volatile anesthetics (halothane) has been studied using quartz crystal microbalance (QCM) method and quartz crystal impedance (QCI) method. The quartz crystal oscillator was attached horizontally on the DHP monolayer tha...

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Bibliographic Details
Published in:	Colloids and surfaces. A, Physicochemical and engineering aspects Vol. 317; no. 1; pp. 568 - 575
Main Authors:	Yamamoto, Yasushi, Ando, Tomoyo, Takayama, Mariko, Egami, Tomoko, Ohtsu, Yumiko, Sakurai, Aiko, Yoshida, Tadayoshi, Taga, Keijiro, Kamaya, Hiroshi, Ueda, Issaku
Format:	Journal Article
Language:	English
Published:	Amsterdam Elsevier B.V 01-03-2008 Elsevier
Subjects:	Anesthesia mechanism Chemistry Colloidal state and disperse state Exact sciences and technology General and physical chemistry Halothane hydrate Interfacial structured water Phospholipid monolayer/water interface Quartz crystal oscillator method Surface physical chemistry Interfacial structured water Phospholipid monolayer/water interface Anesthesia mechanism Halothane hydrate Quartz crystal oscillator method Water Monolayer Crystals Phospholipid Quartz Volatiles Mechanism Interface Hydrates
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Summary:	The interaction between phospholipid monolayer (dihexadecyl phosphate: DHP) and volatile anesthetics (halothane) has been studied using quartz crystal microbalance (QCM) method and quartz crystal impedance (QCI) method. The quartz crystal oscillator was attached horizontally on the DHP monolayer that was formed on the water surface. At quite low halothane concentrations (≤4 mM), no change of frequency for QCM and resistance for QCI was observed. At low concentrations (6–13 mM), the frequency decreased and the resistance increased concomitant with the increased concentration. Both frequency and resistance approached saturation values asymptotically. The concentration at which the frequency changed (6 mM) differed from that at which the resistance changed (9 mM). At high concentrations (>14 mM), both frequency and resistance showed a sudden and discontinuous change (a frequency decrease and a resistance increase). These results indicate the following action mechanism of halothane on DHP monolayer: at low halothane concentrations, the halothane hydrates adsorb into the DHP monolayer/water interface. Subsequently, DHP monolayer/water interface reconstruction occurs because of the interaction and aggregation between adsorbed halothane hydrates with an increase in the hydrate on the interface, i.e., an increase in the DHP monolayer viscosity. At high concentrations, multilayer formation of halothane hydrates and/or promotion of the aggregation of halothane hydrates occur on the DHP monolayer/water interface. The viscosity of the interfacial layer (DHP monolayer and interfacial structured water) changes according to the action of halothane hydrates.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0927-7757 1873-4359
DOI:	10.1016/j.colsurfa.2007.11.037