Search Results - "Efremov, G"

Architecture and conformational switch mechanism of the ryanodine receptor by Efremov, Rouslan G., Leitner, Alexander, Aebersold, Ruedi, Raunser, Stefan

“…Muscle contraction is initiated by the release of calcium (Ca 2+ ) from the sarcoplasmic reticulum into the cytoplasm of myocytes through ryanodine receptors…”
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Structure of the membrane domain of respiratory complex I by Efremov, Rouslan G., Sazanov, Leonid A.

“…Complex I is the first and largest enzyme of the respiratory chain, coupling electron transfer between NADH and ubiquinone to the translocation of four protons…”
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Dynamic “Molecular Portraits” of Biomembranes Drawn by Their Lateral Nanoscale Inhomogeneities by Efremov, Roman G.

“…To date, it has been reliably shown that the lipid bilayer/water interface can be thoroughly characterized by a sophisticated so-called “dynamic molecular…”
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Structure of Escherichia coli respiratory complex I reconstituted into lipid nanodiscs reveals an uncoupled conformation by Kolata, Piotr, Efremov, Rouslan G

“…Respiratory complex I is a multi-subunit membrane protein complex that reversibly couples NADH oxidation and ubiquinone reduction with proton translocation…”
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Coma‐corrected rapid single‐particle cryo‐EM data collection on the CRYO ARM 300 by Efremov, Rouslan G., Stroobants, Annelore

“…Single‐particle cryogenic electron microscopy has recently become a major method for determining the structures of proteins and protein complexes. This has…”
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Lipid Nanodiscs as a Tool for High-Resolution Structure Determination of Membrane Proteins by Single-Particle Cryo-EM by Efremov, Rouslan G, Gatsogiannis, Christos, Raunser, Stefan

“…The "resolution revolution" in electron cryomicroscopy (cryo-EM) profoundly changed structural biology of membrane proteins. Near-atomic structures of medium…”
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Dielectric-Dependent Strength of Interlipid Hydrogen Bonding in Biomembranes: Model Case Study by Efremov, R. G

“…Atomistic aspects of the structural organization, dynamics, and functioning of hydrated lipid bilayersmodel cell membranesare primarily governed by the fine…”
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Structural mechanism of heat-induced opening of a temperature-sensitive TRP channel by Nadezhdin, Kirill D., Neuberger, Arthur, Trofimov, Yuri A., Krylov, Nikolay A., Sinica, Viktor, Kupko, Nikita, Vlachova, Viktorie, Zakharian, Eleonora, Efremov, Roman G., Sobolevsky, Alexander I.

“…Numerous physiological functions rely on distinguishing temperature through temperature-sensitive transient receptor potential channels (thermo-TRPs). Although…”
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The coupling mechanism of respiratory complex I — A structural and evolutionary perspective by Efremov, Rouslan G., Sazanov, Leonid A.

“…Complex I is a key enzyme of the respiratory chain in many organisms. This multi-protein complex with an intricate evolutionary history originated from the…”
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Inconspicuous Yet Indispensable: The Coronavirus Spike Transmembrane Domain by Aliper, Elena T, Efremov, Roman G

“…Membrane-spanning portions of proteins’ polypeptide chains are commonly known as their transmembrane domains (TMDs). The structural organisation and dynamic…”
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Influence of Lipid Mimetics on Gating of Ryanodine Receptor by Willegems, Katrien, Efremov, Rouslan G.

“…Understanding gating principles of ion channels at high resolution is of great importance. Here we investigate the conformational transition from closed to…”
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B-cell receptor signaling and genetic lesions in TP53 and CDKN2A/CDKN2B cooperate in Richter transformation by Chakraborty, Supriya, Martines, Claudio, Porro, Fabiola, Fortunati, Ilaria, Bonato, Alice, Dimishkovska, Marija, Piazza, Silvano, Yadav, Brijesh S., Innocenti, Idanna, Fazio, Rosa, Vaisitti, Tiziana, Deaglio, Silvia, Zamò, Alberto, Dimovski, Aleksandar J., Laurenti, Luca, Efremov, Dimitar G.

“…B-cell receptor (BCR) signals play a critical role in the pathogenesis of chronic lymphocytic leukemia (CLL), but their role in regulating CLL cell…”
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Editorial: The notch signaling pathway in lymphoid malignancies by Fais, Franco, Efremov, Dimitar G

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Apo and Aβ46-bound γ-secretase structures provide insights into amyloid-β processing by the APH-1B isoform by Odorčić, Ivica, Hamed, Mohamed Belal, Lismont, Sam, Chávez-Gutiérrez, Lucía, Efremov, Rouslan G.

“…Deposition of amyloid-β (Aβ) peptides in the brain is a hallmark of Alzheimer’s disease. Aβs are generated through sequential proteolysis of the amyloid…”
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Mechanism of Tc toxin action revealed in molecular detail by Meusch, Dominic, Gatsogiannis, Christos, Efremov, Rouslan G., Lang, Alexander E., Hofnagel, Oliver, Vetter, Ingrid R., Aktories, Klaus, Raunser, Stefan

“…Tripartite Tc toxin complexes of bacterial pathogens perforate the host membrane and translocate toxic enzymes into the host cell, including in humans. The…”
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Structural mechanism of human oncochannel TRPV6 inhibition by the natural phytoestrogen genistein by Neuberger, Arthur, Trofimov, Yury A., Yelshanskaya, Maria V., Nadezhdin, Kirill D., Krylov, Nikolay A., Efremov, Roman G., Sobolevsky, Alexander I.

“…Calcium-selective oncochannel TRPV6 is the major driver of cell proliferation in human cancers. While significant effort has been invested in the development…”
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Respiratory complex I: ‘steam engine’ of the cell? by Efremov, Rouslan G, Sazanov, Leonid A

“…[Display omitted] ► Structures of reduced hydrophilic domain show how NADH interacts with enzyme. ► Architectures of the membrane domain and of the entire…”
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The Akt/Mcl-1 pathway plays a prominent role in mediating antiapoptotic signals downstream of the B-cell receptor in chronic lymphocytic leukemia B cells by Longo, Pablo G., Laurenti, Luca, Gobessi, Stefania, Sica, Simona, Leone, Giuseppe, Efremov, Dimitar G.

“…Sustained engagement of the B-cell receptor (BCR) increases apoptosis resistance in chronic lymphocytic leukemia (CLL) B cells, whereas transient stimulation…”
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libxtc: an efficient library for reading XTC-compressed MD trajectory data by Krylov, Nikolay A, Efremov, Roman G

“…The purpose of this work is to optimize the processing of molecular dynamics (MD) trajectory data obtained for large biomolecular systems. Two popular software…”
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Protein compactness and interaction valency define the architecture of a biomolecular condensate across scales by Polyansky, Anton A, Gallego, Laura D, Efremov, Roman G, Köhler, Alwin, Zagrovic, Bojan

“…Non-membrane-bound biomolecular condensates have been proposed to represent an important mode of subcellular organization in diverse biological settings…”
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