Search Results - "Efferson, Clay L"

Prostate Tumor Cells Infected with a Recombinant Influenza Virus Expressing a Truncated NS1 Protein Activate Cytolytic CD8+ Cells To Recognize Noninfected Tumor Cells by EFFERSON, Clay L, TSUDA, Naotake, KAWANO, Kouichiro, NISTAL-VILLAN, Estanislao, SELLAPPAN, Shankhar, DIHUA YU, MURRAY, James L, GARCIA-SASTRE, Adolfo, IOANNIDES, Constantin G

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Clinical Studies of Vaccines Targeting Breast Cancer by KO, Byung K, KAWANO, Kouichiro, MURRAY, James L, DISIS, Mary L, EFFERSON, Clay L, KUERER, Henry M, PEOPLES, George E, IOANNIDES, Constantin G

“…Many clinical studies have been undertaken to assess the therapeutic potential of vaccination and have included a large variety of cancer immunogens. Most of…”
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Activation of Tumor Antigen-Specific Cytotoxic T Lymphocytes (CTLs) by Human Dendritic Cells Infected with an Attenuated Influenza A Virus Expressing a CTL Epitope Derived from the HER-2/neu Proto-Oncogene by Efferson, Clay L, Schickli, Jeanne, Ko, Byung Kyum, Kawano, Kouichiro, Mouzi, Sara, Palese, Peter, García-Sastre, Adolfo, Ioannides, Constantin G

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Downregulation of Notch Pathway by a γ-Secretase Inhibitor Attenuates AKT/Mammalian Target of Rapamycin Signaling and Glucose Uptake in an ERBB2 Transgenic Breast Cancer Model by EFFERSON, Clay L, WINKELMANN, Christopher T, BUSER, Carolyn, YEATMAN, Timothy, COPPOLA, Domenico, WINTER, Christopher, CLARK, Edwin A, DRAETTA, Giulio F, STRACK, Peter R, MAJUMDER, Pradip K, WARE, Christopher, SULLIVAN, Timothy, GIAMPAOLI, Saverio, TAMMAM, Jennifer, PATEL, Shailendra, MESITI, Giuseppe, REILLY, John F, GIBSON, Raymond E

“…ERBB2/neu and Notch signaling are known to be deregulated in many human cancers. However, pathway cross-talk and dependencies are not well understood. In this…”
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Inhibition of Tumor Growth Progression by Antiandrogens and mTOR Inhibitor in a Pten-Deficient Mouse Model of Prostate Cancer by WEISHENG ZHANG, ZHU, Joe, SUR, Cyrille, MAJUMDER, Pradip K, EFFERSON, Clay L, WARE, Chris, TAMMAM, Jennifer, ANGAGAW, Minilik, LASKEY, Jason, BETTANO, Kimberly A, KASIBHATLA, Shailaja, REILLY, John F

“…Androgen receptors have been shown to play a critical role in prostate cancer. We used ultrasound imaging techniques to track tumor response to antiandrogen…”
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A peptidoglycan monomer with the glutamine to serine change and basic peptides bind in silico to TLR-2 (403–455) by Li, Yufeng, Efferson, Clay L., Ramesh, Rajagopal, Peoples, George E., Hwu, Patrick, Ioannides, Constantin G.

“…Bacterial cell wall polysaccharides, such as PGN, bind and activate TLR-2, NOD2 and PGRP on monocytes/macrophages and activate inflammation. We found that the…”
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Synthetic microRNA and double-stranded RNA targeting the 3'-untranslated region of HER-2/neu mRNA inhibit HER-2 protein expression in ovarian cancer cells by Tsuda, Naotake, Kawano, Kouichiro, Efferson, Clay L, Ioannides, Constantin G

“…MicroRNA (miRNA) are a class of non-coding RNAs found both in normal tissues and cancer cells. The natural miRNA, which target cancer genes for transcriptional…”
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Fine specificity of high molecular weight-melanoma-associated antigen-specific cytotoxic T lymphocytes elicited by anti-idiotypic monoclonal antibodies in patients with melanoma by MURRAY, James L, GILLOGLY, Michael, KAWANO, Kouichiro, EFFERSON, Clay L, LEE, Jeffrey E, ROSS, Merrick, XINHUI WANG, FERRONE, Soldano, IOANNIDES, Constantin G

“…HLA-A2-restricted CTLs, which lysed high molecular weight (HMW)-melanoma-associated antigen (MAA)(+) melanoma cells, were induced in patients with melanoma…”
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Sensitivity of undifferentiated, high-TCR density CD8+ cells to methylene groups appended to tumor antigen determines their differentiation or death by KAWANO, Kouichiro, EFFERSON, Clay L, PEOPLES, George E, CARTER, Darrick, TSUDA, Naotake, MURRAY, James L, IOANNIDES, Constantin G

“…CD8(+) cells expressing high numbers of TCR per cell (TCR(hi)) are considered important mediators of antitumor effects. To understand the relationship between…”
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Mitogen stimulation activates different signaling pathways in early- and late-divided T cells as revealed by cDNA microarray analysis by Li, Yufeng, Wong, Kwong-Kwok, Matsueda, Satoko, Efferson, Clay L, Chang, David Z, Ioannides, Constantin G, Tsuda, Naotake

“…Mobilization of tumor-reactive CD8+ T cells remains the major challenge of cancer immunotherapy. Knowing how and when the T cell response expands and…”
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Induction of Tumor-Reactive CTL by C-Side Chain Variants of the CTL Epitope HER-2/neu Protooncogene (369-377) Selected by Molecular Modeling of the Peptide: HLA-A2 Complex by Castilleja, Agapito, Carter, Darrick, Efferson, Clay L, Ward, Nancy E, Kawano, Kouichiro, Fisk, Bryan, Kudelka, Andrzej P, Gershenson, David M, Murray, James L, O'Brian, Catherine A, Ioannides, Constantin G

“…To design side chain variants for modulation of immunogenicity, we modeled the complex of the HLA-A2 molecule with an immunodominant peptide, E75, from the…”
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Stimulation of Human T Cells by an Influenza A Vector Expressing a CTL Epitope from the HER-2/neu Protooncogene Results in Higher Numbers of Antigen-specific TCRhi Cells than Stimulation with Peptide. Divergent Roles of IL-2 and IL-15 by EFFERSON, Clay L, KAWANO, Kouichiro, TSUDA, Naotake, PALESE, Peter, GARCIA-SASTRE, Adolfo, IOANNIDES, Constantin G

“…Development of cancer vaccines requires approaches to induce expansion and functional differentiation of tumor antigen-specific effector and memory cells. The…”
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Stimulation of cells from a non-invaded and an invaded lymph node with a HER-2+ tumor with peptides corresponding to T-cell epitopes E75 and G89 induced expansion of central memory cells (TCM) from the metastasis-negative lymph nodes by Ko, Byung K, Efferson, Clay L, Kawano, Kouichiro, Kuerer, Henry M, Sahin, Aysegul, Murray, James L, Ioannides, Constantin G

“…Breast cancer metastasizes from the primary site to the axillary lymph nodes (LN). It is unknown whether tumor metastasis abolishes or enhances the ability of…”
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Helper peptide G89 (HER-2:777-789) and G89-activated cells regulate the survival of effectors induced by the CTL epitope E75 (HER-2, 369-377). Correlation with the IFN-gamma: IL-10 balance by Lee, Tom V, Johnston, Dennis A, Thomakos, Nicholas, Honda, Toshie, Efferson, Clay L, Ioannides, Constantin G

“…The CTL response to Ag expands after priming and subsequently contracts reducing the number of effectors. CD4+ cells are described as regulators of CTL…”
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Treatment with HER-2 phosphorylation agonists enhance tumor ability to stimulate epitope specific CTL in vitro by Castilleja, Agapito, Ward, Nancy E, Epstein, Richard B, Kudelka, Andrzej P, Gershenson, David M, Efferson, Clay L, O'Brian, Catherine A, Ioannides, Constantin G

“…The transmembrane (TM) receptor encoded by the HER-2 proto-oncogene (HER-2) is amplified in several types of human carcinomas and premalignant states and…”
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Inhibition of Notch by gamma‐secretase inhibitors induces apoptosis through activated caspase‐3 in LS‐1034 colon cancer model by Efferson, Clay L, Elbi, Cem, Tammam, Jennifer, Carroll, Pamela, Kohl, Nancy E, Majumder, Pradip K

“…The Notch pathway is an evolutionarily conserved regulator of cellular differentiation in many tissues during development and later through adult life. It has…”
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Sensitivity of Undifferentiated, High-TCR Density CD8 super(+) Cells to Methylene Groups Appended to Tumor Antigen Determines Their Differentiation or Death by Kawano, Kouichiro, Efferson, Clay L, Peoples, George E, Carter, Darrick, Tsuda, Naotake, Murray, James L, Ioannides, Constantin G

“…CD8 super(+) cells expressing high numbers of TCR per cell (TCR super(hi)) are considered important mediators of antitumor effects. To understand the…”
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Prostate Tumor Cells Infected with a Recombinant Influenza Virus Expressing a Truncated NS1 Protein Activate Cytolytic CD8 super(+) Cells To Recognize Noninfected Tumor Cells by Efferson, Clay L, Tsuda, Naotake, Kawano, Kouichiro, Nistal-Villan, Estanislao, Sellappan, Shankhar, Yu, Dihua, Murray, James L, Garcia-Sastre, Adolfo, Ioannides, Constantin G

“…Many viral oncolytic approaches against cancer are based on the ability of specific viruses to replicate in tumors expressing components of the constitutively…”
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