Search Results - "Eertwegh, Alfons J. van den"

Improved Survival with Ipilimumab in Patients with Metastatic Melanoma by Hodi, F. Stephen, O'Day, Steven J, McDermott, David F, Weber, Robert W, Weber, Jeffrey S, Sosman, Jeffrey A, Haanen, John B, Gonzalez, Rene, Robert, Caroline, Schadendorf, Dirk, Hassel, Jessica C, Akerley, Wallace, van den Eertwegh, Alfons J.M, Lutzky, Jose, Lorigan, Paul, Vaubel, Julia M, Linette, Gerald P, Hogg, David, Ottensmeier, Christian H, Lebbé, Celeste, Peschel, Christian, Quirt, Ian, Clark, Joseph I, Wolchok, Jedd D, Tian, Jason, Yellin, Michael J, Nichol, Geoffrey M, Hoos, Axel, Urba, Walter J

“…The authors treated 676 patients with metastatic melanoma with an antibody to CTLA-4 (ipilimumab), the antibody plus a gp100 vaccine, or the vaccine alone…”
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Combined immunotherapy with granulocyte-macrophage colony-stimulating factor-transduced allogeneic prostate cancer cells and ipilimumab in patients with metastatic castration-resistant prostate cancer: a phase 1 dose-escalation trial by van den Eertwegh, Alfons JM, MD, Versluis, Jurjen, MD, van den Berg, H Pieter, MD, Santegoets, Saskia JAM, PhD, van Moorselaar, R Jeroen A, Prof, van der Sluis, Tim M, MD, Gall, Helen E, MNAP, Harding, Thomas C, MD, Jooss, Karin, PhD, Lowy, Israel, MD, Pinedo, Herbert M, Prof, Scheper, Rik J, Prof, Stam, Anita GM, BSc, von Blomberg, B Mary E, PhD, de Gruijl, Tanja D, PhD, Hege, Kristen, MD, Sacks, Natalie, MD, Gerritsen, Winald R, Prof

“…Summary Background The granulocyte-macrophage colony-stimulating factor-transduced allogeneic prostate cancer cells vaccine (GVAX) has antitumour activity…”
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Whole-cell cancer vaccination: from autologous to allogeneic tumor- and dendritic cell-based vaccines by de Gruijl, Tanja D., van den Eertwegh, Alfons J. M., Pinedo, Herbert M., Scheper, Rik J.

“…The field of tumor vaccination is currently undergoing a shift in focus, from individualized tailor-made vaccines to more generally applicable vaccine…”
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Ipilimumab versus placebo after radiotherapy in patients with metastatic castration-resistant prostate cancer that had progressed after docetaxel chemotherapy (CA184-043): a multicentre, randomised, double-blind, phase 3 trial by Kwon, Eugene D, Prof, Drake, Charles G, MD, Scher, Howard I, Prof, Fizazi, Karim, Prof, Bossi, Alberto, MD, van den Eertwegh, Alfons J M, MD, Krainer, Michael, MD, Houede, Nadine, MD, Santos, Ricardo, MD, Mahammedi, Hakim, MD, Ng, Siobhan, MD, Maio, Michele, MD, Franke, Fabio A, MD, Sundar, Santhanam, MBBS, Agarwal, Neeraj, MD, Bergman, Andries M, MD, Ciuleanu, Tudor E, Prof, Korbenfeld, Ernesto, MD, Sengeløv, Lisa, MD, Hansen, Steinbjorn, MD, Logothetis, Christopher, Prof, Beer, Tomasz M, Prof, McHenry, M Brent, PhD, Gagnier, Paul, MD, Liu, David, MD, Gerritsen, Winald R, Prof

“…Summary Background Ipilimumab is a fully human monoclonal antibody that binds cytotoxic T-lymphocyte antigen 4 to enhance antitumour immunity. Our aim was to…”
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Baseline biomarkers of efficacy and on-treatment immune-profile changes associated with bempegaldesleukin plus nivolumab by Gogas, Helen, Ravimohan, Shruthi, Datta, Antara, Chhibber, Aparna, Couselo, Eva Muñoz, Diab, Adi, Pereira, Caio, Quéreux, Gaëlle, Sandhu, Shahneen, Curti, Brendan, Khushalani, Nikhil I., Taylor, Matthew H., Daniels, Gregory A., Spreafico, Anna, Meniawy, Tarek, Van Den Eertwegh, Alfons J. M., Sun, Yongliang, Arriaga, Yull, Zhou, Ming, Long, Georgina V., Lebbé, Céleste

“…In PIVOT IO 001 (NCT03635983), the combination of the investigational interleukin-2 agonist bempegaldesleukin (BEMPEG) with nivolumab (NIVO) had no added…”
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Dual-phase PET-CT to differentiate [18F]Fluoromethylcholine uptake in reactive and malignant lymph nodes in patients with prostate cancer by Oprea-Lager, Daniela E, Vincent, Andrew D, van Moorselaar, Reindert J A, Gerritsen, Winald R, van den Eertwegh, Alfons J M, Eriksson, Jonas, Boellaard, Ronald, Hoekstra, Otto S

“…To investigate whether time-trends of enhanced [(18)F]Fluoromethylcholine ([(18)F]FCH) in lymph nodes (LN) of prostate cancer (PCa) patients can help to…”
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Intradermal CpG-B Activates Both Plasmacytoid and Myeloid Dendritic Cells in the Sentinel Lymph Node of Melanoma Patients by MOLENKAMP, Barbara G, VAN LEEUWEN, Paul A. M, MEIJER, Sybren, SLUIJTER, Berbel J. R, WIJNANDS, Pepijn G. J. T. B, BAARS, Arnold, VAN DEN EERTWEGH, Alfons J. M, SCHEPER, Rik J, DE GRUIJL, Tanja D

“…Purpose: A decrease in the frequency and activation state of dendritic cells in the sentinel lymph node (SLN) has been observed in early stages of melanoma…”
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Clinical activity and tolerability of enzalutamide (MDV3100) in patients with metastatic, castration‐resistant prostate cancer who progress after docetaxel and abiraterone treatment by Badrising, Sushil, van der Noort, Vincent, van Oort, Inge M., van den Berg, H. Pieter, Los, Maartje, Hamberg, Paul, Coenen, Jules L., van den Eertwegh, Alfons J. M., de Jong, Igle J., Kerver, Emile D., van Tinteren, Harm, Bergman, Andries M.

“…BACKGROUND Enzalutamide (Enz) and abiraterone acetate (AA) are hormone treatments that have a proven survival advantage in patients with metastatic,…”
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Health related quality of life outcomes for unresectable stage III or IV melanoma patients receiving ipilimumab treatment by Revicki, Dennis A, van den Eertwegh, Alfons J M, Lorigan, Paul, Lebbe, Celeste, Linette, Gerald, Ottensmeier, Christian H, Safikhani, Shima, Messina, Marianne, Hoos, Axel, Wagner, Samuel, Kotapati, Srividya

“…In an international, randomized Phase III trial ipilimumab demonstrated a significant overall survival benefit in previously treated advanced melanoma…”
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Neoadjuvant sunitinib for surgically complex advanced renal cell cancer of doubtful resectability: initial experience with downsizing to reconsider cytoreductive surgery by Bex, Axel, van der Veldt, Astrid A. M., Blank, Christian, van den Eertwegh, Alfons J. M., Boven, Epie, Horenblas, Simon, Haanen, John

“…Objective To evaluate neoadjuvant sunitinib in patients with synchronous metastatic renal cell cancer (mRCC) to downsize surgically complex tumours and…”
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IL-10 conditioning of human skin affects the distribution of migratory dendritic cell subsets and functional T cell differentiation by Lindenberg, Jelle J, Oosterhoff, Dinja, Sombroek, Claudia C, Lougheed, Sinéad M, Hooijberg, Erik, Stam, Anita G M, Santegoets, Saskia J A M, Tijssen, Henk J, Buter, Jan, Pinedo, Herbert M, van den Eertwegh, Alfons J M, Scheper, Rik J, Koenen, Hans J P M, van de Ven, Rieneke, de Gruijl, Tanja D

“…In cancer patients pervasive systemic suppression of Dendritic Cell (DC) differentiation and maturation can hinder vaccination efficacy. In this study we have…”
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Systematic Review on Infusion Reactions to and Infusion Rate of Monoclonal Antibodies Used in Cancer Treatment by Rombouts, Maurien D, Swart, Eleonora L, VAN DEN Eertwegh, Alfons J M, Crul, Mirjam

“…Patients with cancer who are treated with monoclonal antibodies are at risk for developing infusion reactions. However, for some monoclonal antibodies, the…”
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Selective tumor antigen vaccine delivery to human CD169+ antigen-presenting cells using ganglioside-liposomes by Affandi, Alsya J., Grabowska, Joanna, Olesek, Katarzyna, Venegas, Miguel Lopez, Barbaria, Arnaud, Rodríguez, Ernesto, Mulder, Patrick P. G., Pijffers, Helen J., Ambrosini, Martino, Kalay, Hakan, O’Toole, Tom, Zwart, Eline S., Kazemier, Geert, Nazmi, Kamran, Bikker, Floris J., Stöckl, Johannes, van den Eertwegh, Alfons J. M., de Gruijl, Tanja D., Storm, Gert, van Kooyk, Yvette, den Haan, Joke M. M.

“…Priming of CD8⁺ T cells by dendritic cells (DCs) is crucial for the generation of effective antitumor immune responses. Here, we describe a liposomal vaccine…”
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Human dendritic cell line models for DC differentiation and clinical DC vaccination studies by Santegoets, Saskia J. A. M., Eertwegh, Alfons J. M., Loosdrecht, Arjan A., Scheper, Rik J., Gruijl, Tanja D.

“…Dendritic cells (DC) are increasingly applied in the immunotherapy of cancer. As the development of a standardized DC vaccine product is often hampered by the…”
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Sensitivity of 18F-fluorodihydrotestosterone PET-CT to count statistics and reconstruction protocol in metastatic castration-resistant prostate cancer by Cysouw, Matthijs C. F., Kramer, Gerbrand M., Heijtel, Dennis, Schuit, Robert C., Morris, Michael J., van den Eertwegh, Alfons J. M., Voortman, Jens, Hoekstra, Otto S., Oprea-Lager, Daniela E., Boellaard, Ronald

“…Objectives Whole body [ 18 F]-fluorodihydrotestosterone positron emission tomography ([ 18 F]FDHT PET) imaging directly targets the androgen receptor and is a…”
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Increased numbers of small circulating endothelial cells in renal cell cancer patients treated with sunitinib by Vroling, Laura, van der Veldt, Astrid A. M., de Haas, Richard R., Haanen, John B. A. G., Schuurhuis, Gerrit Jan, Kuik, Dirk J., van Cruijsen, Hester, Verheul, Henk M. W., van den Eertwegh, Alfons J. M., Hoekman, Klaas, Boven, Epie, van Hinsbergh, Victor W. M., Broxterman, Henk J.

“…Mature circulating endothelial cell (CEC) as well as endothelial progenitor populations may reflect the activity of anti-angiogenic agents on tumor…”
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Genetic Polymorphisms Associated with a Prolonged Progression-Free Survival in Patients with Metastatic Renal Cell Cancer Treated with Sunitinib by VAN DER VELDT, Astrid A. M, EECHOUTE, Karel, GELDERBLOM, Hans, GIETEMA, Jourik, GUCHELAAR, Henk-Jan, VAN ERP, Nielka P, VAN DEN EERTWEGH, Alfons J. M, HAANEN, John B, MATHIJSSEN, Ron H. J, WESSELS, Judith A. M

“…The objective of this study was to identify genetic polymorphisms related to the pharmacokinetics and pharmacodynamics of sunitinib that are associated with a…”
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New developments in the treatment of metastatic melanoma: immune checkpoint inhibitors and targeted therapies by Azijli, Kaamar, Stelloo, Ellen, Peters, Godefridus J, VAN DEN Eertwegh, Alfons J M

“…The incidence of melanoma has been increasing over the past twenty years. Unfortunately, the prognosis of advanced-stage disease is still poor. Advances have…”
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Extent and Location of Tumor-Infiltrating Lymphocytes in Microsatellite-Stable Colon Cancer Predict Outcome to Adjuvant Active Specific Immunotherapy by Turksma, Annelies W, Coupé, Veerle M H, Shamier, Marc C, Lam, Kevin L H, de Weger, Vincent A, Belien, Jeroen A M, van den Eertwegh, Alfons J, Meijer, Gerrit A, Meijer, Chris J L M, Hooijberg, Erik

“…To determine the prognostic and predictive value of tumor-infiltrating lymphocytes (TIL) in colon cancer in a cohort of patients who previously took part in a…”
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Simplified Methods for Quantification of 18F-DCFPyL Uptake in Patients with Prostate Cancer by Jansen, Bernard HE, Yaqub, Maqsood, Voortman, Jens, Cysouw, Matthijs CF, Windhorst, Albert D, Schuit, Robert C, Kramer, Gerbrand M, van den Eertwegh, Alfons JM, Schwarte, Lothar A, Hendrikse, N Harry, Vis, André N, van Moorselaar, Reindert JA, Hoekstra, Otto S, Boellaard, Ronald, Oprea-Lager, Daniela E

“…Radiolabeled prostate-specific membrane antigen (PSMA) PET has demonstrated promising results for prostate cancer (PCa) imaging. Quantification of PSMA…”
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